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Biomedical subjects

T Sasao

Publications and source records attributed to T Sasao.

At least 19 recordsLinked to original sources
PubMed1990

Diffuse sclerosing variant of papillary carcinoma of the thyroid. A histopathological study of four cases.

We present four cases of an unusual diffuse sclerosing variant of papillary carcinoma of the thyroid occurring in Japanese women ranging in age from 17 to 42 years. Macroscopically, both lobes of the thyroid were involved, being diffusely enlarged and firm. Histologically, the tumor was characterized by squamous metaplasia of tumor cells, numerous psammoma bodies, extensive stromal fibrosis, severe lymphocytic infiltration with formation of lymph follicles, and thin bundles of smooth muscle cells in the fibrous stroma. The tumor islands were located mainly within the dilated lymphatic vessels and the metastatic tumor involved the bilateral cervical lymph nodes in all cases. It is assumed that papillary carcinoma of this type invades the thyroid lymphatics during the early stage and, without forming nodular lesions, disseminates to both lobes with extensive metastasis to the cervical lymph nodes. It should be noted that papillary carcinoma of this type often suggests chronic thyroiditis clinically because of the symmetrical enlargement of the thyroid and frequent positive anti-thyroid antibodies in the serum. Some workers have reported the prognosis to be unfavorable because of extensive lymphatic involvement, but the prognosis of this variant has not yet been defined.

Adolescent↗
PubMed1988

[Clinical observations of hepatic artery infusion therapy combined with hepatic artery ligation in metastatic liver cancers].

Twenty-five patients with liver metastases from advanced gastrointestinal cancers were treated by hepatic arterial infusion chemotherapy by insertion of a catheter into the hepatic artery. All patients also underwent ligation of the hepatic artery. The anticancer agents used were adriamycin 10-30 mg, mitomycin C 10-20 mg and 5-fluorouracil 250-500 mg. The effect was assessed according to the criteria for clinical evaluation of chemotherapy for solid cancers by Koyama and Saito. The response rate for partial response was 24.0% among all 25 patients, including 25.0% (2/8) for stomach cancer and 28.6% (4/14) for colorectal cancer. The survival time with palliative resection of the primary lesion was prolonged significantly (p less than 0.05) in comparison with no resection. As for the side effects of hepatic arterial infusion chemotherapy, bone marrow suppression was most frequently found in 80.0% of patients, followed by gastrointestinal symptoms in 68.0%. In addition, fever occurred in 20.0%, stomatitis in 20.0%, liver dysfunction in 16.0% and alopecia in 4.0%. However, the side effects were all controllable. As to hepatic artery ligation, there was no serious complication except for one case of liver abscess.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Adenoma of the breast: histopathological study of 9 cases].

Adenomas of the breast are cellular epithelial lesions, which are subclassified into two types, tubular adenomas (TA) and lactating adenomas (LA). In 3365 cases of benign epithelial tumors of the breast, including fibroadenomas, filed in the Hiroshima Tumor Tissue Registry between 1973 to 1985, only nine adenomas (TA-4, LA-5) or 0.3% were filed. All adenoma cases involved females, with an average of 27.4 years. Grossly, the tumors were found to vary from 1.5 to 5 cm in diameter and were sharply demarcated. Microscopically and ultrastructurally, the small tubules found in TA are identical to normal ducts. According to progress from pregnancy to lactation, the tubular tissue in LA demonstrate breast increasing secretory activities. The absence of TA during pregnancy, the structural similarity and the fact that some LA had already developed into a palpable mass before pregnancy are signs that indicate that all TA and LA share the same biologic process.

Adenoma↗
PubMed1987

A new method for internal biliary drainage in malignant obstructive jaundice. Intrahepatic cholangioenteric bypass via PTCD fistula.

A new surgical method for internal biliary drainage was devised, consisting of percutaneous transhepatic cholangio-drainage (PTCD) and Roux-en-Y anastomosis. The PTCD fistula is connected to the jejunostomy by a drainage catheter buried in the subcutaneous space. As compared with conventional methods for surgical internal biliary drainage, this method has the following advantages: It can be easily performed even when other types of internal drainage are not feasible, the catheter can readily be changed if it becomes obstructed, and percutaneous cholangiography, irrigation or drug infusion can be performed at any time via the drainage catheter.

Adenocarcinoma↗
PubMed1986

[Synovial sarcoma of the abdominal wall].

A case of a synovial sarcoma arising in the abdominal wall in a 60-year-old man is reported. Histologically, a characteristic biphasic cellular pattern with epithelium-like cell complex and fibrosarcomatous spindle cell area was found. Mucinous materials within the epithelium-like cells, intercellular clefts and pseudoglandular spaces stained positively with PAS, alcian blue, colloid iron and mucicarmine stain. The staining characteristics of these materials remained unchanged after treatment with diastase and hyaluronidase. This histochemical finding makes the diagnosis of a peritoneal mesothelioma unlikely. A brief review of previously reported cases of synovial sarcoma arising in the abdominal wall is also presented.

Abdominal Muscles↗
PubMed1985

Nonsurgical treatment of cholecystocholedocholithiasis. A case report.

We have devised nonsurgical cholecystolithotomy for the extremely ill or elderly patients. Nonsurgical treatment of cholecystocholedocholithotomy is possible by combining our nonsurgical cholecystolithotomy with endoscopic sphincterotomy. The procedure is very useful for extremely ill or elderly patents because it is safe and noninvasive. This report describes the nonsurgical treatment of cholecystocholedocholithiasis.

Aged↗
PubMed1985

A new method for nonsurgical cholecystolithotomy.

A new method of nonsurgical removal of gallbladder stones is presented herein. The method consists of two parts: a, ultrasonically guided percutaneous transhepatic gallbladder drainage, and b, extraction of gallbladder stones using a choledochofiberscopic maneuver. The procedure is safe, less stressful than a surgical procedure and easy to perform. The method is useful for extremely ill or elderly patients and those who prefer not to undergo surgical treatment.

Aged↗
PubMed1975

The role of bronchoconstriction in cough reflex.

To investigate the role of bronchoconstriction in the cough reflex, we compared antitussive effects of several drugs with their ability to effect the respiratory tract (i.e. bronchodilation vs. bronchoconstriction). Antitussive activities of five drugs administered either intravenously or orally on electrically-induced cough were evaluated in the non-anesthetized dog. The antitussive activities were as follows: morphine, 0.1 mg/kg (i.v.) and 0.5 mg/kg (p.o.); codeine, 1.0, 4.0; picoperidamine, 2.0, 9.8; piclobetol, 7.6, 9.0; HH-197, 12.5, 143.0, respectively. Morphine, codeine and HH-197 caused bronchoconstriction, but picoperidamine and picrobetol caused bronchodilation. The antitussive and bronchodilatation effects of isoproterenol were abolished by propranolol. Each bronchoconstricting drug (i.e. morphine, codeine and HH-197) was administered concurrently with isoproterenol (10 mug/kg, i.v., and non-antitussive activity), and the cough reflex was observed. Compared with the single administration of each drug, respiratory resistance was decreased and the antitussive effect was increased. These results indicate a strong correlation between bronchodilatation and increased antitussive activity.

Airway Resistance↗