Biomedical subjects

T Schill

Publications and source records attributed to T Schill.

At least 19 recordsLinked to original sources

PubMed2006

Predicting impaired glucose metabolism in women with polycystic ovary syndrome by decision tree modelling.

AIMS/HYPOTHESIS: Polycystic ovary syndrome (PCOS) is a risk factor of type 2 diabetes. Screening for impaired glucose metabolism (IGM) with an OGTT has been recommended, but this is relatively time-consuming and inconvenient. Thus, a strategy that could minimise the need for an OGTT would be beneficial. MATERIALS AND METHODS: Consecutive PCOS patients (n=118) with fasting glucose <6.1 mmol/l were included in the study. Parameters derived from medical history, clinical examination and fasting blood samples were assessed by decision tree modelling for their ability to discriminate women with IGM (2-h OGTT value >/=7.8 mmol/l) from those with NGT. RESULTS: According to the OGTT results, 93 PCOS women had NGT and 25 had IGM. The best decision tree consisted of HOMA-IR, the proinsulin:insulin ratio, proinsulin, 17-OH progesterone and the ratio of luteinising hormone:follicle-stimulating hormone. This tree identified 69 women with NGT. The remaining 49 women included all women with IGM (100% sensitivity, 74% specificity to detect IGM). Pruning this tree to three levels still identified 53 women with NGT (100% sensitivity, 57% specificity to detect IGM). Restricting the data matrix used for tree modelling to medical history and clinical parameters produced a tree using BMI, waist circumference and WHR. Pruning this tree to two levels separated 27 women with NGT (100% sensitivity, 29% specificity to detect IGM). The validity of both trees was tested by a leave-10%-out cross-validation. CONCLUSIONS/INTERPRETATION: Decision trees are useful tools for separating PCOS women with NGT from those with IGM. They can be used for stratifying the metabolic screening of PCOS women, whereby the number of OGTTs can be markedly reduced.

Adult↗

PubMed2000

Use of frozen-thawed testicular sperm for intracytoplasmic sperm injection.

OBJECTIVE: To determine the feasibility of using frozen-thawed testicular spermatozoa for intracytoplasmic sperm injection. DESIGN: Prospective clinical study. SETTING: A university hospital. PATIENT(S): One hundred seventy-five azoospermic men participating in a routine intracytoplasmic sperm injection program. INTERVENTION(S): The men underwent testicular biopsy for cryopreservation of tissue to be used in consecutive intracytoplasmic sperm injection treatment cycles. Their female partners underwent controlled ovarian hyperstimulation for conventional IVF treatment. MAIN OUTCOME MEASURE(S): Fertilization and pregnancy rates. RESULT(S): In 77% of the patients, spermatozoa could be harvested from the testis by an open testicular biopsy technique and used for intracytoplasmic sperm injection after freezing and thawing of testicular tissue. Histopathologic evaluation revealed a Sertoli cell-only pattern in 21%, maturation arrest in 60%, and hypospermatogenesis in 19% of the patients. In 2. 9% of the patients, carcinoma in situ or a germ cell tumor was detected. In all patients, viable spermatozoa could be visualized after the tissue samples were thawed. One hundred thirty-five intracytoplasmic sperm injection treatment cycles were performed, with a fertilization rate of 45% and a clinical pregnancy rate of 30% per oocyte retrieved. CONCLUSION(S): The use of frozen-thawed testicular tissue allows ovarian stimulation of the female partner to be timed and avoids cancellation of ovum pick-up when spermatozoa cannot be retrieved.

Chromosome Aberrations↗

PubMed1999

Transcervical falloscopic dilatation of proximal tubal occlusion. Is there an indication?

Proximal tubal occlusion (PTO), until recently a domain of microsurgery, can also be treated by a transcervical balloon dilatation and/or tubal recanalization. The aim of our study was to evaluate the possibility of transcervical tubal dilatation during transcervical Falloposcopy. Transcervical Falloposcopy and tubal dilatation was performed under laparoscopic control. During a period of 48 months a total of 157 Falloposcopies was performed. Out of a total of 157 patients, 42 patients had PTO confirmed by dye-pertubation during laparoscopy. All patients were referred because of primary or secondary tubal infertility. A total of 18 patients had bilateral PTO by dye-pertubation and of these six patients had successful bilateral and seven patients successful unilateral recanalization. The remaining five patients were unable to recanalize. A total of 24 patients had an unilateral PTO by dye-pertubation, 13 of these patients had a contralateral diseased tube, seven of which could be recanalized. Four patients had contralateral normal tubes, with successful recanalization in one patient. Seven patients had an occluded or missing contralateral tube, five of which could be recanalized. A total of 60 tubes with PTO were diagnosed, of which 32 (53.3%) tubes could be recanalized. 20 of these had normal tubes. Only patients with healthy Fallopian tubes carried pregnancies to term (five pregnancies, 12% of all patients). All patients conceived within a period of 3-6 months. We observed no ectopic pregnancy.

Adult↗

PubMed1997

Relationships between Schill's Self-defeating Personality Scale and Coolidge's Personality Disorders Inventory.

81 men and 82 women were administered Schill's (1990) Self-defeating Personality Scale and Coolidge's (1992) Axis Two Inventory. As expected, Schill's and Coolidge's measures of self-defeating personality disorder were highly correlated (.70 for men and .74 for women). Scores on Schill's scale also had correlations > .50 with scores on six of the other personality disorder scales for men and five for women. This argues against self-defeating personality disorder as measured by Schill's scale being a distinct construct. The pattern of the correlations suggests that besides assessing a person's maladaptive self-defeating traits, Schill's measure also may assess the person's anxiety and concerns about interpersonal relationships.

Adolescent↗

PubMed1997

A validity study of the MMPI-TRI Acting-out Scale.

49 college men and 45 women were administered the 1995 MMPI-TRI by Swanson, Templer, Thomas-Dobson, Cannon, Streiner, Reynolds, and Miller and a short form of the MMPI with scales for Subjective Distress, Acting-out, and Psychosis. To test the validity of the Acting-out scale respondents also took measures of sexual and aggressive acting out as well as a measure of alcohol use. They were asked about their use of drugs. Women had significant correlations between scores on the Acting-out Scale and scores on measures of Sexual Sensation Seeking .57, Sexual Compulsion .54, Anger Control -.40, Anger-out .50, Anger-in .32, and Drug Use .40. Men had significant correlations for scores on measures of Sexual Compulsion .51, Anger Control -.39, Anger-in .37, and Alcohol Use .35 but not Anger-out. Results suggest the Acting-out scale is more valid for college women than for men.

Acting Out↗

PubMed1996

Hormone profiles under ovarian stimulation with human menopausal gonadotropin (hMG) and concomitant administration of the gonadotropin releasing hormone (GnRH)-antagonist Cetrorelix at different dosages.

PURPOSE: The premature LH surge in ART programs seems to be avoided by daily administration of the GnRH-antagonist Cetrorelix during the midcycle phase in controlled ovarian hyperstimulation with hMG. The dosage necessary for sufficient suppression of the pituitary gland is not yet defined. METHODS: To elucidate this question three daily dosages (3, 1, 0.5 mg) were administered and the hormone profiles obtained as well as the number of oocytes retrieved, the fertilization rate, and the consumption of HMG were compared. RESULTS: No premature LH surge could be observed at any of the three dosages administered. Both gonadotropins were deeply suppressed. The fertilization rates of the oocytes obtained were 45.3% in the 3-mg group, 53.1% in the 1-mg group, and 67.7% in the 0.5-mg group. The average uses of hMG ampoules were 30 in the 3-mg group, 27 in the 1-mg group, and 26 in the 0.5-mg group. CONCLUSIONS: Cetrolix, 0.5 mg/day, administered during the midcycle phase of controlled ovarian hyperstimulation with hMG is enough to prevent completely the premature LH surge. Perhaps even lower dosages would be sufficient. Regarding fertilization rates and use of hMG, the lower dosage seems to be the most favorable.

Adolescent↗

PubMed1996

Successful combination of transrectal electroejaculation and intracytoplasmic sperm injection in the treatment of anejaculation.

We describe the case of a couple whose infertility was caused by the absence of seminal emission following retroperitoneal surgery for testicular cancer. Ejaculate could be retrieved from the husband by rectal probe electroejaculation (RPE) but sperm quality was so poor that conventional in-vitro fertilization was impossible. With intracytoplasmic sperm injection of spermatozoa retrieved by RPE - a combination not reported previously - we were able to induce a pregnancy with successful outcome.

Adult↗

PubMed1996

Are childhood misbehavior and physical illness factors in the development of self-defeating personality.

49 undergraduate men and 45 women took Schill's 1990 Self-defeating Personality Scale and answered questions about their physical health and misbehavior as children and the amount of attention such behavior elicited from their parents. No support was found for the idea that individuals who currently score more self-defeating had been more likely to engage in such behavior or had been able to gain attention thereby. In fact, these people reported getting less rather than more attention from parents when they were physically ill. Results were discussed as consistent with prior findings wherein self-defeating individuals have described their parents as being nonsupportive, inconsistent, and rejecting.

Adolescent↗

PubMed1996

Relation of reports of sexual abuse to scores on Self Defeating Personality Scale.

One of the suggested antecedents of a pattern of self-defeating behavior has been the experience of sexual abuse. In this study 146 male and 129 female college students self-reported whether they had experienced sexual abuse using Russell's 1983) Sexual Abuse Interview Schedule. Thirty-nine men and 73 women self reported in the affirmative. For both men and women, the abused groups had significantly higher scores on Schill's 1990 Self-defeating Personality Scale. Results were related to other research, e.g., Kisler and Schill's 1995 work which showed scores on the Self-defeating scale were also correlated with scores on measures of bulimia and dissociative experiences.

Adolescent↗

PubMed1996

Self-defeating personality, argumentativeness, and assertive self-statements.

55 men and 55 women were administered Schill's Self-defeating Personality Scale, an argumentativeness scale, and a measure of assertive self-statements. Women with higher scores on the Self-defeating Personality Scale had lower scores on the argumentativeness scale. Both men and women scoring higher on the Self-defeating Personality Scale recalled having thoughts which inhibited them from making assertive statements. These results were discussed as supporting prior research showing that persons reporting more self-defeating characteristics were relatively unassertive.

Adolescent↗

PubMed1995

Morphology in intracytoplasmic sperm injection: preliminary results.

PURPOSE: Direct intracytoplasmic sperm injection (ICSI) is a successful treatment of severe male subfertility. Conventional in vitro fertilization shows poor pregnancy rates especially in cases of severe teratozoospermia. The objective was to determine if severe morphological defects of spermatozoa in oligoasthenoteratozoospermia (OAT) have any impact on the fertilization process in ICSI and if there are any specific morphological characteristics in nonfertilized oocytes after the ICSI procedure. METHODS: Ejaculates and nonfertilized oocytes were investigated by electron microscopy. CONCLUSIONS: The lack of intracytoplasmic sperm-oocyte interaction, not severe sperm defects, displays the most critical role in the fertilization process. Clinical data with fertilization rates of 66% and pregnancy rates of 23.3% confirm the fertilization capacity of severely

Acrosome↗

PubMed1995

[Morphology in intracytoplasmic sperm injection].

OBJECTIVE: Was to determine if severe morphological defects of spermatozoa in Oligo-Astheno-Teratozoospermia (OAT) have any impact on the fertilization process in intracytoplasmic sperm injection (ICSI) and, if there are any specific morphological characteristics of unfertilized oocytes after the ICSI procedure. METHODS: Ejaculates of males with severe subfertility and unfertilized oocytes after the ICSI procedure were investigated by transmissionelectronmicroscopy. RESULTS: ICSI provided a fertilization rate of 66% in cases of severe defective spermatozoa. The ultrastructure revealed severe head and neck alterations in particular. The ultrastructure of the unfertilized oocyte displayed mostly no signs of activation and lack of decondensation of sperm chromatin. CONCLUSIONS: Our findings support the hypothesis that not severe sperm defects but the lack of intracytoplasmic sperm-oocyte interaction displays the most critical role in the fertilization process in intracytoplasmic sperm injection.

Female↗

PubMed1995

Chronic self-destructiveness and self-defeating personality: similarities and differences.

This study attempts to determine whether the Chronic Self-Destructiveness Scale (CSDS; Kelley, Byrne, et al., 1985) would be better described as a measure of impulsiveness or self-defeating behavior in the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., Rev. [DSM-III-R]; American Psychiatric Association, 1987) diagnostic sense. Subjects completed the CSDS, the Self-Defeating Scale (Schill, 1990), and measures of restraint, distress, and psychopathy. Based on the correlations among these scales, we suggest that the CSDS is better described as a measure of impulsiveness, poor judgment, and immediate gratification, rather than a measure of Self-Defeating Personality, which keeps the individual in a victim position.

Adolescent↗

PubMed1995

Relation among self-defeating personality, troubled eating patterns, and dissociation.

Significant small correlations were found between scores on a measure of self-defeating personality with scores on the Bulimia Test-Revised (r = .27) and also scores on the Dissociative Experiences Scale (r = .20) for a sample of 165 college women. The correlation between the Bulimia Test and the Dissociative Experiences Scale was .26. Although the research literature led us to expect stronger relationships on theoretical and empirical grounds, it appears these small relationships were more likely due to the fact that scoring higher on all these measures indicates greater psychopathology.

Adolescent↗

PubMed1995

Self-defeating personality and depression: a closer look.

55 men and 55 women were given Schill's Self-defeating Personality Scale, a measure of Beck's cognitive triad, and a measure of the personality dimensions of sociotropy and autonomy. The more characteristics of self-defeating personality endorsed, the more negative were subjects' cognitions about themselves, the world, and the future. Self-defeating men and women scored higher on sociotropy (social dependence), suggesting threats to relationships may be an important source of depression for them. Self-defeating women also scored higher on the autonomy subscales, suggesting threats to their independence may be a source of depression as well. Implications for treatment were discussed.

Adolescent↗

PubMed1995

Social skills of persons with self-defeating personality.

55 undergraduate men and 55 women took Schill's 1990 Self-defeating Personality Scale and Lorr, Youniss, and Stefic's (1991) multidimensional Social Relations Survey. As expected, persons who endorsed more self-defeating characteristics scored lower on scales which make up the Social Skills or Assertiveness Factor. However, these scores did not have significant correlations with the Empathy or Social Approval Need Scales; two of the three scales which make up the Empathy Factor. The results were discussed in terms of prior work relating deficits in social skills to dysfunctional early parenting.

Adolescent↗

PubMed1994

Self-defeating personality, depression, and pleasure from activities.

Prior research has shown people who scored high on a measure of self-defeating personality experienced less pleasure from various activities and accomplishments. The present research replicated the initial study with 55 men and 60 women, while controlling for the effects of depression. Analyses indicated that, while depression and self-defeating personality were related, depression was not the entire answer for why people with self-defeating personality derive less pleasure from activities.

Adult↗

PubMed1994

The relationship between self-monitored aggression and the MMPI-2 F, 4, 9 composite and anger content scale scores.

Undergraduates, 47 men and 79 women, took the MMPI-2 and self-monitored their aggressive acting out for one week. As expected, the MMPI composite score for F, 4, 9 and the anger content scale were correlated positively with monitored aggressive acting out, particularly for men. However, the magnitude of the correlations was slight, indicating it would be inappropriate to use them to make critical judgments regarding aggressive acting out with this population.

Adult↗