Omeprazole in ulcerative colitis.
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Adult↗
Biomedical subjects
T Schlegelberger
Publications and source records attributed to T Schlegelberger.
[Interaction of cyclosporin and ethambutol-isoniazid].
A 34-year-old patient prophylactically received tuberculostatic treatment with ethambutol and isoniazide after having had an allogenic renal transplant and immunosuppression with methylprednisolone and cyclosporine. The tuberculostatic treatment was discontinued 165 days after the transplantation. The cyclosporine blood level, which was measured daily thereafter, gradually rose from 250 ng/ml to 400 ng/ml. It is possible that enzyme induction due by the tuberculostatic drugs was responsible for the increased breakdown of cyclosporine.
Adult↗
Influenza subtype-specific IgA, IgM and IgG responses in patients on hemodialysis after influenza vaccination.
The isotype-specific antibody response to influenza vaccination in 36 patients undergoing chronic intermittent hemodialysis was analyzed by an influenza subtype-specific immunofluorescence test. The immune response was recorded at regular intervals over five months. On the basis of fourfold IgG titer rises as the classical parameter protection from infection was assumed to occur in more than 85% of healthy adults to each of the influenza antigens. In contrast, about 70% of the patients on hemodialysis had responded to influenza A H1N1 and H3N2 vaccines while only 50% of the patients on hemodialysis had responded to influenza B antigen. However, patients showed decreased rates and lower peak responses in IgA, IgM and IgG antibodies to influenza A and B antigens. Probably as a result of the underlying renal disease the different kinetics of antibody responses and the lower influenza specific immunoglobulin levels resulted in lower seroconversion rates in hemodialysis patients compared to those in healthy volunteers.
Adult↗
Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus.
In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE), coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.
Adolescent↗
[Detection of T cell independent B cell maturation disorder in cocultivation studies in systemic lupus erythematosus].
Lymphocyte coculture experiments were performed in a case of monozygotic twins, discordant for SLE. Lack of responsiveness to T-cell-dependent and independent B-cell stimulation gave evidence of an intrinsic B-cell defect in the SLE twin.
Adolescent↗
[Monozygotic twins with Klinefelter syndrome (concordant) and systemic lupus erythematodes (discordant)].
Monozygotic twins, both with Klinefelter's syndrome, are presented. One of them had clinical and serological evidence of systemic lupus erythematosus (SLE), whereas the other did not show any immunological disorder. In relation to this case of discordant SLE the role played by exogenous factors in triggering the manifestation of this autoimmune disease under a certain genetic predisposition is discussed.
Adolescent↗
[The packing density of supragranular pigment-laden stellate cells in phylogenetically older and newer portions of the human telencephalic cortex].
Conspicuous pigment deposits which can be intensely stained by aldehydefuchsin characterize a type of small stellate cell. These can mainly be found in the supragranular layers (layers II and III) of the human isocortex. The packing density of these cells has been evaluated in different cortical areas. The blocks used were cut out of the brain in such a manner as to include phylogenetically older parts of the cortex, fields of intermediate differentiation, and mature isocortex. The counting results verify a gradual increase in the packing density of the supragranular pigment-laden stellate cells from phylogenetically older to newer portions of the telencephalic cortex.
Astrocytes↗