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Biomedical subjects

T Segal

Publications and source records attributed to T Segal.

9 recordsLinked to original sources
PubMed1999

Follicular cutaneous T-cell lymphoma: a clinicopathological study of nine cases.

Nine patients with follicular cutaneous T-cell lymphoma (CTCL), a recently described variant of lymphoma, are presented. On the basis of clinical manifestations and disease course, three groups of patients were distinguished: (i) two patients with follicular CTCL not associated with conventional lesions of mycosis fungoides (MF) and showing no evolution towards MF in follow-up periods of 3 and 6 years; (ii) one patient with follicular CTCL that evolved into conventional MF within 3 years; (iii) six patients showing conventional MF lesions either before or concurrently with the follicular lesions and thus representing follicular CTCL of the true MF type. The follicular lesions included hair-devoid patches or plaques with spiky hyperkeratotic papules (four patients), keratosis pilaris-like lesions (four), comedo-like lesions (four), follicular papules with alopecia (three) and milia-like lesions (three). Histopathological examination showed perifollicular and intrafollicular lymphocytes, without mucin deposition and with minimal or no involvement of the overlying epidermis. Significant syringotropism was also observed in three cases. Immunohistochemical analysis showed the predominance of CD4 + T cells, deletion of CD7 in some cases, Ki-67 + lymphocytes confined mainly to the follicular epithelium, and expression of keratinocyte intercellular adhesion molecule-1 exclusively in the hair follicle. T-cell receptor gamma gene rearrangement was positive in the one case studied from each group. Different treatment modalities were employed, the most commonly used as monotherapy being phototherapy: psoralen ultraviolet A in four patients, two of whom showed a complete clinical and histopathological remission, and ultraviolet B in one patient, who showed a complete remission (both clinical and histopathological). This study indicates that follicular CTCL is more common than reflected in the literature, has heterogeneous clinical manifestations, and is either an expression of or closely related to MF. The influence of the follicular involvement on the therapeutic response remains to be clarified. However, our therapeutic experience clearly suggests that some patients with follicular CTCL can benefit from phototherapy.

Adult↗
PubMed1998

Lipoamide dehydrogenase deficiency: a newly discovered cause of acute hepatitis in adults.

Lipoamide dehydrogenase deficiency is a rare disease, manifested in early childhood by lactic acidemia, progressive neurological damage and death in most cases. We report a case of lipoamide dehydrogenase deficiency in a 34-year-old Ashkenazi-Jewish woman. The deficiency manifested as acute hepatitis without cognitive impairment or acidosis. The patient's brother also had lipoamide dehydrogenase deficiency, diagnosed at the age of 20, and manifested as hepatocellular damage, lactic acidemia and myoglobinuria. We assume that the trigger for this hepatocellular damage was prolonged fasting, and that otherwise the patient might have gone undiagnosed. Other cases in Ashkenazi Jews of mild lipoamide dehydrogenase deficiency with hepatocellular injury but without central nervous system involvement are reviewed.

Acute Disease↗
PubMed1997

Pulmonary thrombo-embolism in nephrotic syndrome treated with tissue plasminogen activator.

UNLABELLED: We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION: Pulmonary thrombo-embolism should be considered in unwell children with nephrotic syndrome.

Child, Preschool↗
PubMed1987

Examination of tooth pulp following laser beam irradiation.

An attempt was made to determine the maximum amount of laser energy which could be utilized without impairing pulpal vitality. Forty rat molar teeth were irradiated in vivo; the Sharplan CO2 laser modality, focused to a 0.2-mm-diameter spot size was used. The energy output was varied by changing the power and/or the pulse duration. Subsequent histological examination of the irradiated teeth showed that the duration of exposure was more significant than the power. A pulse of 0.2 sec/10 W appears to be the safety limit in preserving pulpal vitality.

Animals↗
PubMed1987

GnRH analogs stimulate phospholipase C activity in mammary tumor membranes: modulation by GTP.

An in vitro assay for phospholipase C activity was developed, employing exogenously added 32P-labelled phosphatidylinositol 4,5-bisphosphate as substrate. This enzymatic assay used to analyse the direct effect of GnRH on mammary tumors. GnRH agonists stimulate membranal phosphoinositide-specific phospholipase C activity. The increase in inositoltrisphosphate production is dose dependent, and is inhibited by the GnRH antagonist Org-30276. We took advantage of this non-cellular assay system for evaluating the role of G-binding proteins in the phosphoinositide transducing system in mammary tumors. GTP gamma S stimulates the basal and GnRH-dependent phospholipase C activity. This effect was abolished by GDP beta S. The cytosolic phospholipase C activity was also stimulated by GTP gamma S but was not affected by the hormone. These results suggest that GnRH may affect the growth of mammary tumors directly and not only through the reduction of blood gonadotropin level.

Animals↗