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Biomedical subjects

T Shimbo

Publications and source records attributed to T Shimbo.

At least 55 records · Page 3Linked to original sources
PubMed1984

Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved.

Prostatic cancer in 1885 autopsy cases was classified according to the number of organs involved in metastasis, and a comparison was made concerning the frequency of metastasis to the various organs. The frequencies of metastasis to the lungs and para-aortic lymph nodes were low in cases with single-organ involvement (4.6% and 2.3%, respectively), but increased rectilinearly in accordance with the number of organs involved and became high in cases with metastasis to three or more organs (49.1% and 21.8% in total, respectively). On the other hand, the frequencies of local extension to the bladder and invasion of the pelvic lymph nodes were high even in cases with single-organ involvement (34.5% and 9.2%, respectively) and were not significantly changed regardless of the number of organs involved. No significant correlation was seen between pelvic and para-aortic lymph node involvement. In cases with single-organ involvement, metastasis to the lumbar spine occurred frequently, but those to the ribs, sternum, and ilium occurred less frequently. There may be multiple metastases in cases with metastases to the para-aortic lymph nodes, sternum, and ilium. The number of metastatically involved organs is useful in analyzing the mode of metastasis.

Aged↗
PubMed1984

Autopsy findings in maintenance hemodialysis patients.

From March, 1976 to June, 1983, 22 patients (10 males, 12 females) treated by maintenance hemodialysis were autopsied in our department. Primary diseases of the autopsied cases were chronic glomerulonephritis (12 cases), diabetes mellitus (three cases), hydronephrosis (three cases), systematic lupus erythematosus (two cases), myeloma kidney (one case) and atherosclerosing nephropathy (one case). Direct causes of death in maintenance hemodialysis patients were bleeding (six cases), uremia (three cases), infection (three cases), carcinoma (four cases), heart failure (two cases), myocardial infarction (one case), brain ischemia (one case), cardiac tamponade (one case) and unknown (one case).

Adult↗
PubMed1983

Clinical report of diabetic patients treated by chronic hemodialysis.

Twenty one diabetic patients were treated by chronic hemodialysis (HD) in the seven year period from 1975 to 1982 in our Department. The actual one-year and five-year survival rate for diabetic patients treated by maintenance HD were 76% and 43%, respectively. Blood urea nitrogen and serum creatinine levels at the HD induction were 111.95 +/- 28.51 mg/dl and 10.73 +/- 4.56 mg/dl, respectively. There were complications in the form of blindness in 8 cases (38.1%), peripheral nerve impairment in 17 cases (81.0%), myopathy in 8 cases (38.1%), diabetic gangrene in 3 cases (14.3%) and glaucoma in one case (4.8%).

Adult↗
PubMed1983

Secondary hyperparathyroidism in patients on maintenance hemodialysis: study of the N and C-terminal parathyroid hormones.

In 34 dialysis patients without secondary hyperparathyroidism and 10 dialysis patients with secondary hyperparathyroidism, the concentration of parathyroid hormone, total calcium, ionized calcium, inorganic phosphate, total alkaline phosphatase and bone alkaline phosphatase in serum were determined. The following results were obtained: serum N and C-terminal parathyroid hormone levels, serum total and ionized calcium levels, and serum total and bone alkaline phosphatase levels in dialysis patients with secondary hyperparathyroidism were higher than the corresponding values in cases of negative secondary hyperparathyroidism. Serum phosphate levels in dialysis patients with and without secondary hyperparathyroidism did not differ. Serum bone alkaline phosphatase activities were well correlated with serum total alkaline phosphatase activities in patients on hemodialysis.

Adolescent↗
PubMed1983

Secondary hyperparathyroidism in patients on maintenance hemodialysis: study of optimal hemopurification and parathyroidectomy.

We have found that hemofiltration and direct hemoperfusion combined with hemodialysis removed significant amounts of parathyroid hormone. Hemofiltration and direct hemoperfusion combined with hemodialysis seemed to have better effects on secondary hyperparathyroidism. Surgical parathyroidectomy is indicated when medical parathyroidectomy has failed to prevent progressive bone disease. We had ten patients with refractory secondary hyperparathyroidism. In these patients, subtotal parathyroidectomy was attempted. The results obtained were: 1) Subtotal parathyroidectomy was successful in all patients. 2) Preoperative serum parathyroid hormone values were useful for diagnosis of secondary hyperparathyroidism. 3) The average serum N and C-terminal parathyroid hormone values measured preoperatively were 4,491.00 +/- 892.13 pg/ml and 4,580.00 +/- 474.48 pg/ml, respectively. 4) The average N and C-terminal parathyroid hormone values measured postoperatively were 298.60 +/- 128.68 pg/ml and 2,631.00 +/- 719.51 pg/ml, respectively.

Adult↗
PubMed1982

Metastatic processes and a potential indication of treatment for metastatic lesions of renal adenocarcinoma.

Renal adenocarcinoma findings from 307 autopsied cases with metastasis to 1 and 2 organs were investigated concerning the mode of metastasis. The lung was the most frequent site of metastasis to 1 organ, although the frequency was rather low (30 per cent), followed by bones (over-all), lymph nodes (over-all) and brain, and involving frequently the thoracic spine and retroperitoneal lymph nodes. In patients with metastases to 2 organs a significant correlation was found between the pulmonary-tracheal lymph nodes and those to the lungs. Potential indications for treatment of metastatic lesions were 1) lymphadenectomy and/or radiation therapy for the retroperitoneal and para-aortic lymph nodes and 2) resection of metastatic lesions in the lungs combined with lymphadenectomy and/or radiation therapy for the pulmonary-tracheal lymph nodes. In patients without lung metastasis lymphadenectomy and/or radiation therapy for the pulmonary-tracheal lymph nodes is not always necessary.

Adenocarcinoma↗
PubMed1982

Red blood cell types and living related renal transplantation.

We studied the effects of red blood cell types on 34 cases of living related renal transplantation. Red blood cell types were examined retrospectively concerning the ABO, Lewis, P, Rh-Hr, Kell, Duffy and MNSs systems in both donors and recipients. The correlation between red blood cell type and acute rejection in HLA identical pairs and the effects of the Lewis, P and other systems on graft outcome in HLA semi-identical pairs were considered. In the HLA identical group, the Rh-Hr and MNSs systems participated in acute rejection. In addition to the ABO and Rh-Hr systems, the Lewis and P systems influenced the graft rejection in the HLA semi-identical group.

ABO Blood-Group System↗
PubMed1982

Complication of renal neoplasms with cystic disease: an indication for nephrectomy in potential transplant recipients.

Thirty-five (1.1%) out of a total of 3,133 autopsied cases of renal tumors were complicated by renal malignant tumors and cystic renal disease. They accounted for 1.4% of 2,417 cases of renal malignant tumors and for 4.7% of 751 cases of cystic renal disease. Among the 35 complicated cases, 10 cases or 28.6% were free of metastasis. The incidence of complicated cases and those without metastasis aged over 60 years or over was 12.2% and 29.2% respectively, while the 10-59 year-old age group displayed a lower incidence of 3.6% and the same incidence of 27.3% respectively. In 26 out of 35 cases the malignant tumors was renal adenocarcinoma with no evidence of metastasis in nine cases (34.6%). Although it is unknown whether cystic renal disease undergoes malignant changes, not all of the patients undergoing chronic hemodialysis should be indicated for nephrectomies since such patients with renal malignancies are mostly elderly and are frequently free from metastases.

Adolescent↗
PubMed1982

Report on blood access for hemodialysis in the Department of Transplantation, Tokai University School of Medicine and a satellite hospital.

There were 316 patients being treated by maintenance hemodialysis in the Department of Transplantation, Tokai University School of Medicine and its satellite hospital (Bohsei Clinic, Medical Treatment Cooperation, Showakai) as of December 31, 1981. Forty eight male (23.1%) and 39 female (35.7%) patients were operated on for external shunts. One case of external shunt was functioning well 48 months later. No patient was dialysed through external shunts on December 31, 1981 in our Department or the satellite. The majority of patients, who were maintained on hemodialysis with an arteriovenous (native vein) fistula available, experienced no difficulties. Nearly 50 percent of cases with the first fistula were functioning on December 31, 1981. There were some complications with fistulas such as pseudoaneurysms, infections, the sore thumb syndrome or the steal syndrome. We experienced 14 hemodialysis cases using expanded polytetrafluoroethylene (E-PTFE) grafts and one case using femoral artery repositioning as blood access.

Adolescent↗
PubMed1982

Brain metastasis of renal adenocarcinoma.

Among 1,828 autopsy cases of adenocarcinoma reviewed, 177 cases (9.7%) were found to have brain metastasis, and their autopsy records were analyzed to investigate the mode of dissemination of the cancer to the brain. Brain metastases were most frequent in the age group of 50-59 years but showed no significant difference in incidence between sexes or location (right or left) of the primary lesion. The cases with brain metastases had greater frequencies of metastases in the lungs, heart, thyroid and skull than cases without brain metastases. Lung metastasis was most frequent in cases with two-organ metastases, and lung metastasis with involvement of the hilar lymph nodes in cases with three-organ metastases. Metastasis to the brain was significantly more frequent in nephrectomized cases than in non-nephrectomized cases. Metastases to the contralateral kidney and peritoneum were significantly more frequent in nephrectomized cases with brain metastasis. Possible routes of dissemination of the cancer to the brain are discussed.

Adenocarcinoma↗
PubMed1982

Metastasis of renal sarcoma.

Data from 27 autopsy cases of renal sarcoma were investigated concerning the mode of metastases. The incidence was 1% in 2,651 cases of new growths of the kidney. Histologically nine were leiomyosarcoma, and five each were rhabdomyosarcoma and fibrosarcoma. The lungs, lymph nodes and liver were the most frequent sites of metastases. No significant differences in metastatic sites were noted among the histological types. Two cases or 7% had no metastasis and this percentage is comparable to that for other new growths of the kidney.

Adult↗