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Biomedical subjects

T Shindoh

Publications and source records attributed to T Shindoh.

11 recordsLinked to original sources
PubMed2001

[A newly designed system, "FC-UV-CDDP", and a study of its oncolytic effect].

We devised a fibrin clot (FC) using an ultraviolet (UV)-crosslinking method. To evaluate the in vivo chemotherapeutic effects for cancer chemotherapy with our novel drug delivery system, the anticancer agent cis-platinum (CDDP) was impregnated into each FC and this "FC-UV-CDDP" was intraperitoneally (i.p.) administered to each ascitic hepatoma AH-130 in cancer-bearing rats. Other groups of AH-130 bearing rats, i.p. injected with CDDP or non-treated, served as the controls. We recorded the survival period of each animal and autopsied it at the time of death. All the animals treated with "FC-UV-CDDP" survived for more than 5 weeks and had no retention of ascites. Furthermore, all the surviving rats underwent a challenge with AH-130 cells. Two of 3 repeatedly challenged rats revealed no evidence of recurrence of the cancer and survived for more than 3 months. The control rats died of cachexia with a massive ascites within 2 weeks. Thus, our newly devised "FC-UV-CDDP" system favorably functioned in an experimental cancer model. These data suggested that this oncolytic effect was attributed to the possibility of inducing immune responses against AH-130 as well as to a sustained release of CDDP from FC.

Animals↗
PubMed1997

[Clinical significance of myocardial 123I-BMIPP imaging in patients with myocardial infarction].

In order to clarify the characteristics of fatty acid metabolism in patients with myocardial infarction (MI), we performed myocardial imaging with 123I-beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) and we compared these findings with exercise stress (Ex) and resting myocardial perfusion imaging with 99mTc-methoxyisobutylisonitrile (MIBI) and left ventricular wall motion index (WMI) which were obtained by left ventriculography. We studied 55 patients with MI, 14 patients with recent MI (RMI) and 41 patients with old MI (OMI), and myocardial images were divided into 17 segments and myocardial uptake of the radionuclide was graded from 0 (normal) to 3 (maximal abnormality). In 28 patients we compared segmental defect score (SDS) with WMI which were obtained by centerline method at the corresponded segments. As a whole, the mean total defect scores (TDSs) of BMIPP and Ex were similar and they were greater than the mean TDS of resting perfusion. In 30 patient (55%) TDS of BMIPP was greater than that of TDS of resting perfusion. In 24 patients perfusion abnormality developed by Ex and the location of BMIPP abnormality coincided with the abnormality of Ex. But in the other 6 patients Ex did not induce any abnormality and they were all RMI and infarcted coronary artery was patent. However in the group with TDS of BMIPP identical to TDS of resting perfusion (25 patients), 92% did not show myocardial perfusion abnormality after Ex. In the comparison of SDS and WMI, myocardial segments were divided into 3 groups; both SDSs of BMIPP and resting perfusion were normal or borderline abnormality (Group 1, 82 segments), SDS of resting perfusion was normal or borderline and SDS of BMIPP was definitely abnormal (Group 2, 10 segments) and both SDSs of BMIPP and resting perfusion were definitely abnormal (Group 3, 48 segments). In Group 1, WMS (-0.41 +/- 0.77) was significantly (p < 0.001) greater than those of Group 2 (-2.14 +/- 0.50) and Group 3 (-2.32 +/- 0.67). But there was no difference between Group 2 and 3. These findings suggested that in the segments with mismatch between BMIPP and resting perfusion reflects stunned myocardium. These results suggested that in half of the patients with MI, abnormal fatty acid metabolism may appear in viable myocardium such as jeopardized myocardium and myocardium which recently recovered from severe ischemia like acute MI and BMIPP imaging was useful to know the history of myocardial ischemia.

Adult↗
PubMed1996

[Regional left ventricular contraction kinetics in patients with hypertrophic cardiomyopathy: investigation by ECG-gated myocardial SPECT with 99mTc-MIBI].

To investigate the regional left ventricular (LV) contraction kinetics in patients with hypertrophic cardiomyopathy (HCM), we performed ECG gated myocardial tomography (gated-SPECT) with 99mTc methoxy-2-isobutyl isonitrile (MIBI) at rest in 11 patients with HCM and 13 normal subjects. In order to evaluate regional LV contraction kinetics, multi-plane long axial tomograms were constructed and LV was divided into 17 segments. From the time activity curve of myocardial count, percent change during systole (%CC) was calculated in each segment. Normal range of %CC in each segment was derived from normal files. Systolic asynchrony in each patient was expressed as SD (standard deviation) of R-wave to peak count (R-PC) intervals of 17 segments. Decreased %CC was observed in 87 of 187 segments (47%) in HCM (8 +/- 5 segments/patient, range; 2-14 segments/patient). SD in patients with HCM was significantly greater than that in normal subjects (5.9 +/- 1.3 vs. 3.5 +/- 0.6, p < 0.01). The extent of decreased %CC in patients with HCM correlated well with global 123I-BMIPP (BMIPP) uptake and the extent of regional abnormality of BMIPP (Defect Score) (r = -0.79, r = 0.88 each, p < 0.01). On the other hand, SD correlated well with left ventricular (LV) filling rate during early diastole (r = -0.66, p < 0.01). Patients with HCM were divided into 2 groups whether LV ejection fraction (EF) increased (Group 1) or decreased (Group 2) by exercise stress. SD in Group 2 was significantly greater than that in Group 1. In segments with decreased %CC, the distribution of R-PC interval was different with that in segments with normal %CC. These results suggested that indexes which were derived from gated-SPECT with MIBI could bring several informations which were important to assess the pathologic condition of HCM.

Adult↗
PubMed1995

[Assessment of left ventricular contraction kinetics by ECG-gated myocardial SPECT with 99mTc-MIBI: a new attempt with multi-plane long axial tomography].

To investigate left ventricular (LV) contraction kinetics, we performed ECG gated myocardial tomography (gated-SPECT) with 99mTc-MIBI (99mTc methoxy-2-isobutyl isonitrile) at rest. Data were obtained from 32 views and R-R interval was divided into 16. To clarify whether myocardial count change during systole (%CC) reflected LV wall thickening (%WT), we compared septal and posterior %CC in short axis image with %WT which were obtained by echocardiography. And %CC correlated well with %WT (r = 0.86, p < 0.01). In order to assess myocardial contraction kinetics in various parts of LV, multi-plane long axial tomograms were constructed in 10 normal subjects and 9 patients with myocardial infarction (MI). By multi-plane long axial tomography, LV was divided into 17 segments. In each segment %CC was calculated from time activity curves of myocardial count of 99mTc-MIBI. And the disparity of the appearance of peak count in each segment was also observed. In normal subjects %CC was greatest at apex and they decreased from apex to cardiac base. Besides %CC at lateral segments was greater than that in septal segments. Normal range of %CC was determined segment by segment. In normal subjects the intervals from ECG R-wave to peak count were not different in each segment. But in patients with MI they distributed in wide range and prolonged intervals were observed in segments with rest perfusion defect (infarcted segment). In patients with MI decreased %CC was observed in 91% of infarcted segments, in 83% of the segments with exercise induced ischemia and in 89% of the segments with 123I-BMIPP defects. These results indicated decreased %CC represented viable but compromised myocardium as well as necrotic myocardium. In gated-SPECT we obtained useful informations in addition to myocardial perfusion. But it took more than 30 minutes to perform. More experience will be necessary to ascertain the value of this technique.

Adult↗
PubMed1993

[A case of chronic recurrent pulmonary embolism complicated with effort angina pectoris].

A 50-year-old man was admitted to our hospital because of shortness of breath and an oppressive feeling in his chest on exertion. As a result of examinations including pulmonary-angiography, pulmonary perfusion scan and phlebogram, we diagnosed the case as chronic recurrent pulmonary embolism due to deep vein thrombosis. Later on, the patient showed an abnormal reaction on treadmill exercise test, and revealed redistribution at the anteroseptal and the inferior wall on thallium exercise test. We performed coronary angiography and diagnosed the case as angina pectoris (seg. 1 was total occlusion, segs. 2 and 3 were filled with bridge collateral, seg. 7 was 75% stenotic lesion). We evaluated the acute effect of vasodilators on pulmonary and systemic hemodynamics. The effect was beneficial in that it improved the hemodynamics. On account of this we thought a reversible condition was presented, and we administered these drugs to this patient.

Angina Pectoris↗
PubMed1992

[Locoregional therapy in patients with malignant pleural effusion--two different types of "BAC therapy"].

We used fibrin clot (FC) as a carrier of anticancer drug (AD) to provide a novel therapy for patients with serious malignant pleural effusion. After evacuating the pleural fluid, we enhanced an "FC-AD" formation in the pleural cavity of the patient to prevent this kind of effusion from reaccumulating. In an attempt to enhance FC-AD formation, we used two different procedures; either, fibrinogen/AD/G.T.XIII (procedure I) or fibrin glue/AD (procedure II). G.T.XIII is our newly devised compound drug, composed of biodegradable gelatin (G), thrombin (T) and a blood coagulation factor XIII (XIII). This therapy was termed "Bio-Adhesio-Chemo (BAC) therapy." We conducted BAC therapy 52 times on 44 patients using procedure I and 4 times on 4 patients using procedure II. Complete remission of the effusion was obtained, overall, in 83%, partial remission in 17%, and no non-effective case. The improvement of PS of the patients treated was 73%. Nineteen patients could be discharged with this therapy. Toxic effects with BAC therapy were within Grade 2 in all cases. We could favorably enhance FC-AD formation, in every case, by both procedure I and II. BAC therapy is very promising as a novel cancer chemopleurodesis for patients with malignant pleural effusion.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[Loco-regional cancer chemotherapy in patients with malignant pleural effusion--improving the QOL of patients].

We carried out a new loco-regional cancer chemotherapy for serious patients with malignant pleural effusion, in an attempt to prevent the recurrence of effusion. After removing pleural effusion, fibrinogen solution, anticancer agent and our newly devised compound drug, "G.T.XIII" were intrapleurally instilled to enhance an anticancer fibrin membrane. This pleurodesis was called "Bio-Adhesio-Chemo (BAC) therapy". Some 39 BAC therapies were carried out for 34 patients. There were 32 cases evaluable; 29 resulted in PR, and three were NC. Improvement of P.S. was observed in 77% (30/39). Aggravation of P.S. was nil. Sixteen patients were discharged after showing favorable improvement. Toxic effects with the therapy were rather mild. Such results were attributed to the biomechanism of both the adhesive and oncolytic effects of the fibrin membrane enhanced with BAC therapy. Immunological studies suggested that the fibrin membrane also worked as BRM in the pleural cavity. Our own BAC therapy showed a great potential in improving the QOL of patients with malignant pleural effusion.

Adult↗
PubMedDate not supplied

Intraperitoneal fat sign.

In a patient with an ovarian cystic teratoma and the peritoneal cavity filled with sebaceous material, an abdominal radiograph revealed a wide fat stripe between the parietal peritoneum and the lateral wall of the ascending colon. We called the existence of the wide fat stripe, which implied large amounts of intraperitoneal fatty material, the "intraperitoneal fat sign."

Adult↗