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T Shirabe

Publications and source records attributed to T Shirabe.

At least 55 records · Page 3Linked to original sources
PubMed1980

An autopsy case of Tay-Sachs disease--with special reference to axonal swellings of the central nervous system and freeze-fracture replication studies of the membranous cytoplasmic bodies.

The following is a report of the light and electron microscopic findings of the axonal swellings of the central nervous system and the freeze-fracture replication studies of the membranous cytoplasmic bodies in Tay-Sachs disease. The axonal swellings were observed mainly in the subthalamic nucleus, thalamus, globus pallidus, red nucleus, dentate nucleus, inferior olivary nucleus, nucleus gracilis, spinal anterior nucleus and so on. They contained many electron dense bodies and neurofilaments. Typical membranous cytoplasmic bodies were not seen in these axonal swellings. The freeze-fracture replication studies demonstrated that the membranous cytoplasmic bodies were composed of parallel stacks or concentric whorls of lamellae at an interval of 5 to 6 nm, with membrane-associated particles of 8 to 10 nm diameters on their protoplasmic face. It was postulated that the membranous cytoplasmic bodies constituted various compound lipids including the GM2-ganglioside and some proteins.

Axons↗
PubMed1979

An autopsy case of protracted necrotic encephalitis with marked atrophy of unilateral temporal lobe.

Clinical and neuropathological findings in a case of an unusually protracted encephalitis have been described. The patient was a 44-year-old man who experienced mental deterioration, right abducens and facial paresis, right and, subsequently, left hemiparesis, and consciousness disturbance with an intermittent low grade fever and occasional headache during one year and three months. Electroenphalograms showed periodic lateralized epileptiform discharges. Virus titers including herpes simplex virus were all normal. Neuropathological examinations revealed marked atrophic changes in the right temporal lobe, insular lobe and hippocampus with minimal inflammatory signs. The distribution of the lesions was almost identical with that of acute necrotic encephalitis or herpes simplex encephalitis despite its unusually protracted course.

Adult↗
PubMed1978

Electron microscopic X-ray microanalysis of the nervous system after mercury intoxication.

The nervous system of the rats with methyl mercury intoxication was studied by a recently developed electron microscopic X-ray microanalytical technique. A mercury element was detected at the lysosome-like dense bodies of the peripheral nerves and of the cerebellum, especially prominent at the dense bodies of the collapsing cells. Mercury was also suggested at the dilated endoplasmic reticulum of Schwann cells. It may be apparent that mercury itself practically penetrates into the cells of the nervous system and directly destructs them. Except for the lysosome-like dense bodies and occasional endoplasmic reticulum, however, the precise localization and distribution of minimal amounts of mercury element within the cells were difficult to evaluate by this method, because a peak for mercury was overlapped occasionally with that of sulphur when they were so scanty in quantity.

Animals↗
PubMed1977

X-ray microanalytical studies of lead-implanted rat brains.

Various cytoplasmic and intranuclear inclusions found in macrophages and astrocytes of lead-implanted rat brains were studied with an energy dispersive x-ray microanalytical technique. Cytoplasmic inclusions contained large quantities of lead, calcium and phosphorus. The proportions of these elements were different within each inclusion. Intranuclear inclusions also contained small amounts of lead and, occasionally, calcium.

Animals↗
PubMed1977

Periodic EEG patterns observed in two cases with partial seizures.

Two cases with partial seizure and periodic EEG pattern were reported. Case 1. A 74-year-old woman reveal typical periodic lateralized epileptiform discharges (PLED's) on the right hemisphere. The patient was semicomatous with mild jaundice and epilepsia partialis continua in the left lower limb. Postmortem examination revealed a main metastatic carcinoma of pancreas head origin in the right parietooccipital region. In the right hemisphere, the cortical structures were relatively preserved, but the white matter including the frontal lobe was swollen and its demyelinating changes were observed diffusely. The PLED's might result from an anatomical or functional severance of the cerebral cortex from normal connections with deeper structures. Case 2. A 61-year-old woman, with idiopathic hypoparathyroidism showed partial complex seizure. The EEG revealed an anterior temporal spike focus and slowing in the right hemisphere, corresponding with repetitive seizures of about one minute duration and with several minutes interval. An interictal periodic EEG pattern appeared in the right anterior and mid-temporal region. No cerebral abnormalities were found with other neurological examinations including brain scanning, carotisangiogram, and echoencephalogram. The periodic pattern was assumed as subclinical focal seizure discharges from the right anterior temporal deep structures.

Aged↗
PubMed1977

Familial progressive bulbar-spinal muscular atrophy: case report with muscle biopsy study.

A case of familial progressive bulbar and spinal muscular atrophy was presented. The patient was a 59-year-old male with chief complaints of gait disturbance and nasal voice. His illness started at the age of 39 and very slowly progressed over 20 years. The clinical symptoms and signs were characterized by muscle weakness and atrophy due to lower motor neuron disease in the brain stem below the lower pons and the spinal cord. The electromyograms and muscle biopsy findings are basically neurogenic. In spite of the bulbar signs, the course of the disease is extremely slow. The diagnostic criteria was proposed after reviewing eight other cases reported in the literature.

Adult↗
PubMed1976

Electron microscopic studies of the T-system--the effects of hyperosmolar glycerol and dantrolene sodium on mammalian muscles.

Electron microscopic studies of the T-systems in mammalian muscles were performed to investigate the effects of hyperosmolar glycerol solution and dantrolene sodium. The results indicate that in mammalian muscles the terminal cisterns of the sarcoplasmic reticulum seem to be the site of morphological changes which occur when the muscle specimens were transferred from the hypertonic glycerol solution to isotonic washing solution. When the muscle specimen was further exposed to dantrolene solution, the above changes were intensified. The changes of the terminal cisterns of SR were characterized by prominent vacuolar changes and the T-tubules were pressed and narrowed by those vacuoles secondarily. The glycerol and dantrolene technique did not cause any electron microscopic changes in the sarcolemma, myofibrils, nor Z-discs, and selective changes in the T-system, i.e. at the terminal cisterns of SR were demonstrated. This technique, excitation-contraction uncoupling, abolishes isometric twitch tension up to 99.7% and serves for the purpose of prolonged intracellular recordings of mammalian muscles without movement induced artifacts.

Animals↗
PubMed1975

Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle.

Histopathological findings of biopsied peripheral nerve and muscle were studied in a case with myxoedematous polyneuropathy. The most striking findings in the sural nerve were segmental demyelination and onion bulb formation with scanty mucinous deposits in addition to marked loss of large myelinated nerve fibres. The peroneus brevis muscle revealed the association of neuropathic and myopathic changes. It is suggested that myxoedematous polyneuropathy might be intrinsic neuropathy due to metabolic disorder of Schwann cells related to hypothyroidism, resulting in segmental demyelination, not merely compressive neuropathy due to mucinous deposits in the peripheral nerves.

Aged↗