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T Simonic

Publications and source records attributed to T Simonic.

30 records · Page 2Linked to original sources
PubMed1983

Fasciola hepatica: increase of glycogen phosphorylase activity due to prostaglandins.

Both prostaglandin E1 (PGE1) and prostaglandin F2 alpha (PGF2 alpha) stimulate the glycogen phosphorylase (EC 2.4.1.1.) activity of Fasciola hepatica. Whole or sliced parasites were incubated with PGE1 (2.8 X 10(-7) and 2.8 X 10(-5) M) and PGF2 alpha (2.1 X 10(-7) and 2.1 X 10(-5) M) and enzyme activity was measured in homogenates prepared immediately following the incubation. No substantially different effect was noted between the two assayed doses of prostaglandins. Prostaglandins appeared to be less effective in sliced parasites.

Alprostadil↗
PubMedDate not supplied

Cyclic AMP phosphodiesterase activity in Fasciola hepatica (L.) homogenates.

The authors have studied the bahaviour of cyclic 3',5'-AMP phosphodiesterase in the 2,000 g supernatant of the Fascilola hepatica homogenate, under basal conditions and after addition of various substances. Dopamine remarkably inhibits the enzyme activity, imidazole causes a strong activation, while serotonin, theophylline, PGE1 and PGF2alpha appear to be ineffective.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMedDate not supplied

Influence of age and cortisone treatment on two intestinal lysosomal hydrolases in young rats.

The effects of cortisone acetate injected i.p. on acid phosphatase and beta-glucuronidase in the small intestine mucosa of two groups of rats aging 12-14 and 20-22 days are reported. The following results are obtained: a) Total and free activities of the two enzymes show age-dependent differences. b) Cortisone acetate causes a very marked decrease of the enzymic activities only in the younger rats while being ineffective on the older ones. c) The kinetics of the enzyme release at 37 degrees C appear independent either of age or of cortisone injection. d) The "in vitro" lysosome labilizing treatments are ineffective.

Acid Phosphatase↗