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T Smiley

Publications and source records attributed to T Smiley.

3 recordsLinked to original sources
PubMed2001

The relationship of insulin resistance measured by reliable indexes to coronary artery disease risk factors and outcomes--a systematic review.

OBJECTIVES: To provide a qualitative and quantitative review of the published literature that examines the relationship between reliable markers of insulin resistance and coronary artery disease risk factors (plasma glucose, triglycerides, high density lipoprotein cholesterol, hypertension, obesity, low density lipoprotein size) and outcomes (as related to ischemic heart disease) in populations with and without type 2 diabetes. METHODS: The MEDLINE database was searched (January 1966 to April 2000). Additional references were identified from bibliographies of retrieved articles. The quantitative relationship between insulin resistance and coronary artery disease outcomes was estimated in individual studies by derivation of 2x2 tables. RESULTS: Of 780 publications reviewed, 28 met the inclusion criteria. Twenty publications investigated the relationship of insulin resistance markers with coronary artery disease risk factor profiles only, while eight publications primarily evaluated coronary artery disease outcomes. CONCLUSIONS: The present review suggests that populations with lower insulin resistance measured by reliable indexes are consistently associated with better overall cardiovascular risk profiles (including reduced clustering of risk factors), and improved coronary artery disease outcomes than populations with elevated insulin resistance.

Coronary Disease↗
PubMedDate not supplied

Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis.

The objective was to determine the association of moderate to heavy caffeine consumption during pregnancy on spontaneous abortion and birth weight in humans. Data sources used included a computerized literature search of MEDLINE (1966-July 1996); EMBASE (1988-November 1996); Psychlit I (1974-1986); Psychlit II (1987-1996); CINAHL (1982-May 1996) and manual search of bibliographies of pertinent articles. Inclusion criteria were: English language research articles; pregnant human females; case control or cohort design; documented quantity of caffeine consumption during pregnancy; control group with minimal or no caffeine consumption (0 to 150 mg caffeine/d); documented data regarding spontaneous abortion and/or fetal growth. The exclusion criteria were: case reports; editorials; review papers. The methods section of each study was examined independently by two blinded investigators with a third investigator adjudicating disagreements. Two independent investigators extracted data onto a standardized form. A third investigator adjudicated discrepancies. We compared a caffeine-exposed group (>150 mg/d) and controls (0 to 150 mg/d), using Mantel-Haenszel pooling. Of the 32 studies meeting inclusion criteria, 12 had extractable data (6 for spontaneous abortion, 7 for low birth weight, 1 common study). Mantel-Haenszel odds ratio (CI95%) was 1.36 (1.29-1.45) for spontaneous abortion in 42,988 pregnancies. The overall risk ratio was 1.51 (1.39-1.63) for low birthweight (<2500 g) in 64,268 pregnancies. Control for confounders such as maternal age, smoking, and ethanol use was not possible. We concluded that there is a small but statistically significant increase in the risks for spontaneous abortion and low birthweight babies in pregnant women consuming >150 mg caffeine per d. A possible contribution to these results of maternal age, smoking, ethanol use, or other confounders could not be excluded.

Abortion, Spontaneous↗