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Biomedical subjects

T Smyth

Publications and source records attributed to T Smyth.

12 recordsLinked to original sources

Marginality and the role of the clinical teacher.

This paper discusses the concept of marginality and its relevance to an understanding of the role of the clinical teacher. Despite having a rather chequered history, the notion of marginality has proved, nonetheless, to be a powerful and resilient stimulus for many writers from a variety of backgrounds. After a brief overview of the historical development of the concept, this paper focuses on the theoretical framework proposed by Dickie-Clark which is found to have value as both an accessible and flexible means of analysing a wide range of social and individual phenomena. It is this framework that is used to examine the position of the clinical teacher. The essence of the argument is that the clinical teacher is at a pivotal level at the intersection of two relatively distinct hierarchies (the formal educational and the informal clinical) which need to be reconciled if the clinical teacher is to be effective. Brief references are made also to Third World studies as an illustration of how seemingly remote concepts can be employed creatively to highlight some hitherto unconsidered aspects of the clinical teacher's role.

Culture

Chromium (III) thiamin diphosphate: a new probe of enzyme coenzyme--metal ion binding. Interaction with wheat germ pyruvate decarboxylase.

Chromium (III) thiamin diphosphate (CrTDP) is a substitutionally inert complex which is a physical and kinetic probe of the binding mode of metal ion and coenzyme in thiamin diphosphate (TDP) dependent enzymes. CrTDP is prepared by reaction of aquated Cr (III) and TDP and purifed by ion-exchange chromatography. CrTDP binds to the apoenzyme of wheat germ pyruvate decarboxylase, giving an inactive holoenzyme. Chromium (III) ion binds to the apoenzyme in a manner that suggests, in light of the results with CrTDP, that there are two metal ion binding sites. Extension of the use of CrTDP to other enzymes can give specific information about binding and can introduce an active site reporter group

Apoenzymes