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Biomedical subjects

T Sorvari

Publications and source records attributed to T Sorvari.

18 recordsLinked to original sources
PubMed2006

Past chlamydial infection is not associated with primary fallopian tube carcinoma.

We conducted a retrospective seroepidemiological study to evaluate the relationship between past chlamydial infection and primary fallopian tube carcinoma (PFTC). Postoperative serum samples were drawn from 79 consecutive patients treated for PFTC in 1985-2000. For each case two controls were selected. Serum samples were analysed for IgG antibodies to different C. trachomatis serotype pools and to C. pneumoniae. Seropositivity in general or serum antibody levels to different C. trachomatis serovars or C. pneumoniae did not differ between PFTC patients and controls. The lack of association between anti-chlamydial antibodies and PFTC suggests that past chlamydial infection does not play a role in the etiopathogenesis of PFTC. However, because chlamydial infection is common at young age and PFTC develops decades later, we cannot definitively exclude the possibility that C.trachomatis contributes to the development of PFTC.

Adult↗
PubMed2005

Preoperative serum hCGbeta as a prognostic marker in primary fallopian tube carcinoma.

OBJECTIVES: It was the aim of this study to evaluate the prognostic value of the pretreatment serum concentrations of the beta-subunit of human chorionic gonadotropin (hCGbeta), CA 125 and tumour-associated trypsin inhibitor (TATI) in primary fallopian tube carcinoma (PFTC). METHODS: The pretreatment serum concentrations of hCGbeta, CA 125 and TATI were analyzed in serum samples from 60 women with a mean age of 61 years, treated for PFTC between 1985 and 2000. Of the 91 patients treated during this period, 31 were excluded because no serum sample was available. The patients were followed-up for recurrence and survival until February 14, 2003. The prognostic value of the serum markers were compared with those of stage, grade and histological type. RESULTS: The median survival time was 27 months and the overall 5-year survival rate 33%. Stage and size of the residual tumour (<1 vs. > or =1 cm) predicted both overall and disease-free survival (p < 0.050). Histology (serous vs. others) (p = 0.023) also influenced overall survival. Overall 5-year survival was 38% when serum hCGbeta was below 3.5 pmol/l, while it was 18% when the level was higher (p = 0.052). The corresponding disease-free 5-year survival was 38 and 20%, respectively (p = 0.014). Patients with CA 125 values above 1,017 kU/l had an overall 5-year survival of 39% as compared with 14% for those with lower values (p = 0.009), while the disease-free survival was 37 and 23%, respectively (p = 0.096). Serum TATI was not a prognostic marker. Serum concentrations of hCGbeta and CA 125 correlated significantly with stage (p = 0.049 and p = 0.050, respectively). In multivariate Cox proportional hazards regression analysis, only hCGbeta, stage and histology emerged as independent prognostic factors. CONCLUSIONS: Clearly elevated serum concentrations of hCGbeta and CA 125 predict survival in fallopian tube carcinoma, but in multivariate analyses, only hCGbeta is a prognostic factor independent of stage and histology.

Adult↗
PubMed1988

Type IV collagen in the basal membrane of human papillomavirus associated premalignant and malignant squamous cell lesions of the uterine cervix.

In the present study, the expression of type IV collagen associated with the basal membrane (BM) was studied histochemically (indirect immunoperoxidase-antiperoxidase) in cervical human papillomavirus (HPV) lesions (diagnosed using in situ DNA hybridization) of different grades. The expression of type IV collagen in premalignant epithelial lesions (HPV with and without cervical intraepithelial neoplasia) was identical with that in the BM of normal exocervical epithelium, in contrast to 60% (3/5) of carcinoma in situ lesions and 90% (10/11) of invasive carcinomas, where the staining pattern was interrupted and the staining intensity reduced. Thus, the expression of type IV collagen seems to remain unchanged during the entire spectrum of premalignant stages of cervical HPV lesions. This suggests that the squamous epithelial cells responsible for the formation of the BM are not affected by this virus at early stages of the disease, and immunohistochemical recognition of an intact staining pattern of type IV collagen may signify well-preserved basal cell function (confined to nonmalignant?) HPV-infected squamous epithelium.

Basement Membrane↗
PubMed1986

Effect of a sport drink mixture with and without addition of fluoride and magnesium on plaque formation, dental caries and general health of rats.

A sport drink mixture (pH 3.2) containing 6% sucrose was given to Osborne-Mendel rats for 42 days. In some experimental groups the drink was supplemented with 15 ppm F, 38.5 ppm Mg or both F and Mg. The rats were fed a slightly cariogenic powdered diet containing 15% sucrose. Sport drink mixture increased significantly the accumulation of plaque but, compared with a group that drank distilled water, did not affect caries. Addition of fluoride to the sport drink mixture, alone or with magnesium, significantly reduced caries and tended to decrease plaque; addition of magnesium had no clear effect on plaque or caries. In spite of the fact that the rats had a sport drink mixture as the only drink for 6 wk, there were no untoward effects on growth, in histological studies of the inner organs, or in Ca, Mg, Na and K contents of kidney, heart and aorta.

Animals↗
PubMed1986

Lingua fissurata. A clinical, stereomicroscopic and histopathological study.

The purpose of this study was to describe clinical, stereomicroscopic and light microscopic findings for fissured tongue in 17 patients and compare them with 17 normal controls. Clinical symptoms were found in 13 of 17 patients who complained of scoreness of the tongue. Usually the symptoms lasted more than 3 years. In 15 cases, fissures involved the entire tongue, while in 2 cases, only the edges of the tongue were affected. In all patients, papillae of varying sizes were found in the area of fissures. The papillae were easily noted using stereomicroscopy on fixed-tissue specimens, but could also be seen with the naked eye during careful clinical examinations. Light microscopic studies indicated that the number of inflammatory cells was far greater in the mucosa of fissured tongues than in normal tongues, and this inflammation was not confined only to the fissures. The rete pegs of the epithelium were longer in fissured tongues than in normal tongues, 800 (+/- 79) micron and 620 (+/- 69) micron, respectively, (p less than 0.001). The lamina propria was also thicker in fissured tongues than in normal tongues, 390 (+/- 74) micron and 170 (+/- 61) micron, respectively, (p less than 0.001). In normal tongues, keratohyaline granules were observed in the filiform papillae around the area of hairs but these granules were absent in fissured tongues.

Adult↗
PubMed1985

Changes in composition of whole saliva in patients with fissured tongue.

Both resting and paraffin-stimulated whole saliva were studied in 25 patients with fissured tongue and in their age and sex-matched healthy controls. The groups did not differ in dental or periodontal health. No significant differences were found between the groups in the salivary secretion rate, pH and buffer capacity, or in the frequency of lactobacilli and yeasts in saliva samples and scrapings from tongue surface. In patients with fissured tongue, unstimulated whole saliva displayed significantly elevated levels of sodium, lysozyme, myeloperoxidase and all immunoglobulins (isotypes A, G and M) when compared with the controls. These changes most likely reflect the inflammation frequently seen in the biopsies of fissured tongue. No differences between the groups existed in the amounts of salivary potassium, calcium, inorganic phosphate, amylase and total protein. Our study shows that in patients with fissured tongue the salivary secretion and composition are normal. However, components from plasma and inflammatory cells are diagnostically elevated in the whole saliva samples of patients with fissured tongue when compared with the healthy controls.

Adult↗
PubMed1982

Monoclonal gammopathy with neurological signs and symptoms. A clinical, neurophysiological and muscle biopsy study.

Clinical, neurophysiological and muscle biopsy findings in ten patients with monoclonal gammopathy are reported. Three patients had polyneuropathy, one had hemiparkinsonism, one migraine and radicular symptoms and one paresthesiae and radicular symptoms. Amyloidosis was not found in muscle biopsy specimens. All but one patient with neurological findings also had positive immunofluorescence staining for tissue-bound immunoglobulins in muscle biopsy specimens. The tissue-bound immunoglobulins usually belonged to the same class as the M-component. None of the biopsies of patients without neurological findings were positive.

Aged↗
PubMed1982

Electroneuromyographical and morphological findings in progressive myoclonus epilepsy (PME).

The purpose of this study was to assess the function of peripheral nerves and muscles and to describe morphological changes in muscle biopsies of patients with progressive myoclonus epilepsy. Electroneuromyographic studies were performed on 24 adult patients whose mental and motor skills were either little, moderately or severely impaired by the disease. In 5 patients a specimen of tibial anterior muscle was morphologically and histochemically investigated. The electrophysiological functions of the peripheral nerves and muscles showed gradual increasing abnormalities parallel to the severity of clinical deterioration. The muscle biopsies of 2 patients showed signs compatible with peripheral neuropathy. These findings suggested that progressive myoclonus epilepsy may be related to a systemic membrane disorder.

Adolescent↗
PubMed1975

Healing of a crush injury in rat striated muscle. 1. Description and testing of a new method of inducing a standard injury to the calf muscles.

In this report an apparatus is described which can quickly and reliably induce a standard crushing injury in a desired location of rat calf muscle without tearing the skin. To test the constancy of injury caused by the apparatus, both hind legs of rats were traumatized. Two days after traumatization, the rats were killed and the hind legs were inspected macroscopically and microscopically following prior formalin fixation. The breaking strength of the muscles was measured immediately after traumatization. In every case, the injury totally penetrated the medial head of the gastrocnemius muscle, but never damaged the whole jumping complex of muscles (gastrocnemius, plantaris and soleus). Both the location and the dimensions of the wound as well as the breaking strength of the injured muscles remained inside such narrow limits that the trauma can be regraded as constant.

Animals↗
PubMed1974

Incomplete restoration of the bursa-dependent immune system after transplantation of allogeneic stem cells into immunodeficient chicks.

Transplantation of allogeneic cells from bursa of Fabricius into cyclophosphamide-treated, immunodeficient chicks resulted in immunological tolerance to donor line skin grafts; graft-versus-host disease did not occur. Allogeneic bursal stem cells taken from 3-day-old donors induced restoration of bursal morphology, of antibody formation to Brucella abortus and of occurrence of pyroninophilic cells and immunoglobulin-bearing cells in the peripheral lymphoid tissues. Secondary response to sheep red blood cells and production of germinal centers were not restored. Transplantation of histocompatible bursal stem cells resulted in a complete reconstitution of the bursa-dependent lymphoid system, both in function and in morphology. Allogeneic postbursal stem cells taken from the bursa of 10-week-old donors had a reconstitutive effect only on the production of antibodies to Brucella. Transplanted stem cells maintained their functional potential in the allogeneic environment, since, when transferred back to histocompatible hosts, they displayed normal function. These findings indicate that a complete functional and morphological restoration of the bursa-dependent immune system cannot be achieved without identity of the donor and recipient at loci near to or identical with those determining the major histocompatibility antigens, even though graft-versus-host disease is avoided. This identity permits a full cooperation of the donor and host cells.

Age Factors↗