PubMed Health⌕ Search

Biomedical subjects

T Southee

Publications and source records attributed to T Southee.

7 recordsLinked to original sources
PubMed1985

Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola).

Eleven rhesus monkeys were monitored intensively during experimental infection with Ebola virus. Prominent neutrophilia with left shift and lymphopenia were the earliest abnormalities and were statistically significant by day 4 (P less than .02 and P less than .01, respectively). By day 4 falls in platelet counts were not statistically significant, whereas in vitro platelet aggregation was markedly depressed, progressing rapidly to complete failure by the time of maximum illness. Intraplatelet protein studies suggested this event was the result of in vivo activation and degranulation. Coagulation cascade defects were mainly in the intrinsic system and were surprisingly mild, with no evidence of selective consumption or production deficit of factor VII or VIII. When the possibility of indirectly mediated damage to endothelium possibly by a nonspecific immune response was examined, weight loss was less severe in drug-treated monkeys, and all had detectable plasma prostacyclin metabolites, but there was no improvement in survival.

Animals↗
PubMed1984

Preliminary report on arbovirus-antibody prevalence among patients in Kuwait: evidence of Congo/Crimean virus infection.

From two major hospitals in Kuwait 502 sera were randomly selected from patients during the period December 1979 to October 1982. Serological investigations demonstrated Flavivirus activity in the area and antibody to Congo/Crimean haemorrhagic fever virus was found in 4% of the samples. Clinical data indicate that some cases may have been due to recent Congo/Crimean virus infection.

Adolescent↗
PubMed1981

Congo/Crimean haemorrhagic fever virus from Iraq 1979: I. Morphology in BHK21 cells.

Congo-Crimean Haemorrhagic Fever virus, isolated from a patient in Iraq, was grown, after passage in suckling mouse brain, in BHK cells. The particles matured after 8-9 days in these cells by budding, usually singly, into cytoplasmic vacuoles throughout the host cells. The virions had an overall diameter of 115 to 125 nm, including rounded surface spikes 15 nm long and 10 nm wide. The viral cores, surrounded by a lipid unit membrane, contained discrete electron-dense elements. It is suggested that the spikes, dimpled at their outer end and possibly hollow throughout their length, passed out through "pores" in the unit membrane.

Animals↗