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Biomedical subjects

T Spahn

Publications and source records attributed to T Spahn.

5 recordsLinked to original sources
PubMed1995

Lack of requirement for CD8+ cells in recovery from and resistance to experimental autoimmune encephalomyelitis.

Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell mediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4+ T-cells, whose adoptive transfer can also induce passive disease. In the Lewis rat EAE is a transient disease inducing lasting resistance to rechallenge. The mechanisms of recovery and resistance are poorly understood. CD8+ suppressor T-cells have mostly been thought to be central, especially in resistance to reinduction of the disease. In this study we showed by complete depletion of CD8+ cells that this subset does not influence either recovery or resistance to EAE in the Lewis rat. This was further confirmed by depleting CD8+ cells only after recovery from acute EAE. Such depletion did not diminish the effective resistance to rechallenge. Recovery from and resistance to EAE appear not to require the presence of CD8+ cells.

Animals↗
PubMed1991

Changing patterns of epiglottitis in children.

With an increased awareness of appropriate management of childhood epiglottitis, overall morbidity and mortality has decreased. However, some trends have developed over the past several years that are variations on the classic picture. In a series of 42 patients seen from 1977 to 1986, epiglottitis has occurred in a progressively younger population. Thirty-six percent of our patients were found to be less than 2 years old, and 51% were less than 3 years old. Also, the causative organism, Haemophilus influenzae, has been found to be increasingly ampicillin-resistant. The incidence, presentation, management, and outcome of the patients are reviewed, and compared to similar data from other series in the literature.

Ampicillin↗