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Biomedical subjects

T Stefansson

Publications and source records attributed to T Stefansson.

9 recordsLinked to original sources
PubMed1981

Effects of prolonged anesthesia with enflurane or halothane on renal function in dogs.

Elevated serum inorganic fluoride levels (60-300 mumol/l), maintained over 6 h, influenced renal function in beagle dogs. Changes in water reabsorption were seen with an increased urine flow and free water clearance and decreased urinary concentration capacity. Possible nephrotoxicity as an effect of inorganic fluoride production during prolonged enflurane anesthesia was evaluated in a group of beagle dogs. Another group of dogs, anesthetized with halothane in equianesthetic doses, was studied for comparison. Serum inorganic fluoride levels and urinary oxalate excretion were determined and postanesthetic renal morphology was examined. Renal function was evaluated from endogenous clearances and concentration capacity before and after anesthesia. In the enflurane group, serum inorganic fluoride levels peaked at 22.5 mumol/l at the end of anesthesia and decreased rapidly in the postanesthetic period. Urinary oxalate excretion did not increase. No changes in renal morphology were found. Renal function tests did not reveal any disturbance after enflurane anesthesia. The two anesthetized groups did not differ in any of the parameters studied, except in serum inorganic fluoride levels.

Animals↗
PubMed1981

Effects of renal function on serum fluoride level in dogs during and after enflurane anesthesia.

To study the effect of renal function on the increased serum inorganic fluoride level produced by the metabolism of enflurane, three groups of beagle dogs were exposed to prolonged enflurane anesthesia, 1.25 MAC for 8 h. One group was studied both with and without renal function, one group only without renal function, and one group on two different occasions with renal function intact. Serum inorganic fluoride levels were determined every hour during the enflurane anesthesia and on termination for a further 4 h. In dogs with no renal function, the increase rate and the peak of serum inorganic fluoride level were significantly higher than in dogs with renal function. The average peak level in dogs with renal function was 21.4 mumol/l and in dogs with no renal function 38.4 mumol/l. Renal function was found to have the same capacity to increase the inorganic fluoride elimination from serum as other routes of elimination. At corresponding serum levels, the rate of decrease after terminating enflurane anesthesia was 3.5-4.0 mumol/l/h lower without renal function. Reanesthesia after 3 weeks did not significantly change the serum inorganic fluoride levels compared to the first anesthesia.

Anesthesia, General↗
PubMed1981

Local discomfort and thrombophlebitis following intravenous injection of diazepam. A comparison between a glycoferol-water solution and a lipid emulsion.

Diazepam is frequently used for pre- and peroperative sedation. However, at i.v. injection local pain and thrombophlebitis are not uncommon, probably due to tissue irritancy of the various organic solvents necessary to keep diazepam in aqueous solution. In this study the incidence of local adverse effects following i.v. injection of Diazemuls, a new lipid emulsion formulation, was compared with that of Apozepam, a glycoferol-water solution. We found that the latter preparation caused local pain and thrombophlebitis as often as reported with propyleneglycol-phenylcarbinol-ethanol preparations (Stesolid, Valium) and in a statistically higher incidence that the lipid emulsion form, which therefore seems more suitable for intravenous use.

Adult↗