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Biomedical subjects

T Stevenson

Publications and source records attributed to T Stevenson.

23 records · Page 2Linked to original sources

Streptococcal cellulitis of the scrotum and penis with secondary skin gangrene.

Cellulitis of the scrotum and penis is caused, in the majority of instances, by a beta hemolytic streptococci without a discernible portal of entry. Clostridium, occasionally, will result in this disease as a manifestation of a perirectal abscess. In either instance, fluid accumulates rapidly in the closed space between Colles' and Buck's fascia, producing intense swelling of the scrotum. If this compartment is not immediately decompressed by linear incisions, devascularization of the scrotal and penile skin will often occur, resulting in gangrene. Immediate treatment of the bacterial infection with penicillin also is essential. If gangrene does develop, radical debridement of the necrotic tissue as well as a wide margin of adjacent inflamed skin must be undertaken. Continual monitoring of the microflora of the debrided would is essential for the selection of the appropriate antibiotic against any secondary intruders. Coverage of the granulating would is accomplished when the would bacterial count is below 10-5 per gram of tissue.

Amphotericin B↗

A basic guide to the principles of drug therapy.

Why must glyceryl trinitrate tablets be given sublingually? Why can you crush some tablets but not others? Can drug therapy cause red urine? How can suppositories stop vomiting? This article discusses why certain drugs are given by specific routes of administration and examines issues related to drug therapy, giving examples of drugs used in practice. Clinical tutors may wish to use this and subsequent articles for teaching purposes.

Drug Interactions↗

Drug therapy in the management of Parkinson's disease.

Parkinson's disease affects mainly the elderly population and is characterized by tremor, bradykinesia, rigidity and postural abnormalities. As the disease progresses, drug therapy is inevitable and the strategies used aim to correct the imbalance of neurotransmitters in the CNS. Antimuscarinic drugs counteract the excessive effects of acetylcholine while levodopa, dopamine agonists, selegiline and amantadine supplement or enhance the effects of dopamine. Although initially effective, these therapies are not without problems which include tolerance and long-term effects. This article aims to augment the reader's knowledge of the disease and the drug therapies available, including their place in therapy and their potential side-effects.

Antiparkinson Agents↗