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Biomedical subjects

T Sumii

Publications and source records attributed to T Sumii.

At least 19 recordsLinked to original sources
PubMed1992

Horseshoe anomaly of the pancreas.

A 72-year-old man with recurrent pancreatitis and a horseshoe-shaped anomaly of the pancreas is described. The diagnosis was made by endoscopic retrograde cholangiopancreatography (ERCP) and computed tomography scan; laparotomy was confirmatory. The abnormal duct branched to the lower left from an enlarged Santorini's duct; a thin Wirsung's duct was joined at its distal portion to the junction of the abnormal duct. The anomaly was associated with a cystic dilatation of the common bile duct with stone and cholecystolithiasis. This anomaly is considered to be a variation of the dominant dorsal duct syndrome.

Aged↗
PubMed1992

Serum protease inhibitor capacity for elastase and the severity of pancreatitis.

To clarify the relationship between the diminution of the serum protease inhibitor capacity and the severity of pancreatitis, the binding capacity of serum protease inhibitors for exogenous elastase 1 (E1) was investigated by gel filtration, the elastase activity of the alpha 2-macroglobulin (alpha 2-M)-elastase complex was measured, and the relationship between these findings and the severity of pancreatitis was studied in 13 patients with pancreatic disease and 6 healthy subjects. When 125I-labeled E1 was added to the sera of healthy subjects, it bound to alpha 2-M and alpha 1-protease inhibitor (alpha 1-PI) with a mean ratio of 72:28. In mild acute pancreatitis (n = 5), the binding capacity of alpha 2-M was less than that in healthy subjects. In severe pancreatitis (n = 4), most of the exogenous E1 bound to alpha 1-PI (alpha 2-M vs. alpha 1-PI, 13:87). This diminution in the binding capacity of alpha 2-M correlated well with the severity of acute pancreatitis. In the sera of patients (n = 4) with pancreatic cancer containing much immunoreactive E1, the proportion of exogenous E1 bound by alpha 2-M and alpha 1-PI (25:75) was similar to that seen in severe acute pancreatitis. A significant inverse relationship between the binding capacity of alpha 2-M and the activity of the endogenous elastase bound to alpha 2-M was seen in various pancreatic diseases.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1991

Alteration of cholecystokinin receptor binding after caerulein-induced pancreatitis in rats.

The alteration of CCK receptor binding on the pancreatic acini in vitro following the induction of pancreatitis was investigated in male rats. Pancreatitis was induced by administering 5 intraperitoneal injections of caerulein, 40 micrograms/kg each at hourly intervals. The uptake of [3H]-thymidine in the pancreatic acini increased on day 7 following caerulein administration. The release of amylase stimulated by CCK-8, and CCK receptor analysis using bioactive [125I]-BH-CCK-8, were performed at regeneration stage, on days 14 and 28 following the injections. The maximal release of amylase stimulated by CCK-8 was reduced on day 14 by about 40% and recovered on day 28. On day 14 there was a decrease of 60% in the number of high-affinity receptors and an increase of 161% in the number of low-affinity receptors. On day 28 there was a 128% increase in the number of low-affinity receptors. Accordingly, we suggest that the CCK receptors of the regenerating cells following caerulein-induced pancreatitis differ from those of the intact cells.

Amylases↗
PubMed1991

Properties of hydroxyapatite-coated Ti-6Al-4V alloy produced by the ion-plating method.

To improvement the brittleness of hydroxyapatite (HAp) coated on titanium alloy (Ti-6Al-4V), a thin ceramic layer was formed by means of the RF ion-plating method. The alloy substrates were coated with HAp at 1, 3 or 5 microns thickness and heat-treated at 500 degrees C for 4 hours. Properties of HAp-coated alloy were evaluated by characterization of the ceramic films both before and after heat-treatment, as well as by bending, electrochemical and dissolution tests. HAp-coated film had a slightly higher Ca/P ratio than the original material and was stoichiometrically Ca10(PO4)6(OH)2 by EPMA analysis. HAp was mainly recognized crystallographically by XRD analysis of the films after heat treatment, though it was hardly recognized on before heat-treatment film. These coated materials had a residual strain ranging from 0.3 to 0.7% without causing cracks in the HAp films with the three-point bend testing. Electrochemically, it was confirmed that the corrosion resistance of the Ti alloy was improved by any coating process. The amounts of Ca released from HAp coated film in 0.9% NaCl solution tended to increase with films that were 3 and 5 microns in thickness, but there were no significant differences in Ca released from film before and after heat treatment.

Aluminum Oxide↗
PubMed1991

Characteristic behavior of serum elastase 1 in pancreatic cancer.

Diagnostic significance of serum immunoreactive elastase 1 (IRE) in pancreatic cancer was evaluated in 53 patients with pancreatic cancer. Frequency of abnormally high serum IRE levels in pancreatic cancer was 66.0%; 87.0% in head cancer (N = 23), 55.0% in body & tail cancer (N = 20) and 40% in diffuse cancer (N = 10). Serum IRE level in resectable cancer was significantly higher than that in unresectable cancer. Comparative studies of serum pancreatic enzymes revealed that serum IRE was the most sensitive marker for diagnosis of pancreatic cancer. The characteristic behavior of serum IRE throughout the course of pancreatic cancer was that abnormally high levels of IRE are maintained for a longer period of time when compared to that of pancreatitis. In the comparative study of serum IRE and CA19-9, of the 9 cases of pancreatic cancer with CA19-9 levels less than 100U/ml, 7 showed abnormally high values of IRE, and of these 4 were resectable. These results indicate that in order to detect early pancreatic cancer, any elevation of serum IRE before CA19-9 increase should be noted with care, and patients who particularly show elevated IRE values for more than one month should be subjected to more extensive morphological examinations.

Adult↗
PubMed1990

The pattern design for evaluation of castability of nickel-chromium alloys.

To find a pattern design that would provide a higher degree of discrimination for castability of nickel-chromium alloys using a polyester sieve cloth pattern, four shaped patterns were chosen. The results as calculated by t-test indicated that patterns No. 2 and No. 3 can discriminate the castability of nickel-chromium alloys over almost the total range of the casting temperatures, but that pattern No. 3 is a better discriminator for the castability. Pattern No. 1 can only discriminate the castability at lower casting temperatures. Pattern No. 4 can only discriminate the castability at higher casting temperatures. The percent castability value calculated from the number of complete square segments and the areas of the four patterns are highly linear correlations, so it is reasonably accurate to calculate the castability only from counting the number of complete square segments. Beryllium-containing nickel-chromium alloy is more castable than non-beryllium-containing alloy and the higher casting temperatures appear to result in better castability.

Beryllium↗
PubMed1990

A study of the method of making dental prosthetic appliances by sintered titanium alloys: effect of copper powder content on properties of sintered titanium alloy.

The effects of added copper powder to the properties of the sintered titanium alloys were investigated by measuring the compressive strength and densities of the green and sintered compacts, the thermal expansion curves and dimensional changes in the sintered compacts, and the accuracy of the crown-type restorations. The compressive strengths of green compacts ranged from 55 to 75 MPa. The expansion of green compacts increased with increased copper content. The sintered density was lower than the green density. The compressive yield strength of sintered compacts ranged from 260 MPa to 410 MPa. The sintered compacts expanded from 0.35% to 1.03% and the expansion increased with increased copper content. The dimensional accuracy of crown-type restorations showed the same dimensional change tendencies as did the sintered compacts. These results showed that the fit and the strength of sintered titanium alloy restorations could be improved.

Copper↗
PubMed1990

[The study on surface porosity of die stone. Influence of vinyl polysiloxane impression materials].

In this study, the authors have attempted to discover optimum conditions for eliminating all porosity, except what is caused by manual error, in the surfaces of Die Stone. Five vinyl-porisiloxane impression materials, two other kinds rubber impression materials, and two kinds of die materials were used. Die materials were poured at intervals of 0, 15, 30, 60, and 120 minutes after the impression had been removed. Cast-surface porosity was measured by means of SPICCA II. Results 1. Practically surface porosities were not scarcely observed in casts made from any of the impression materials except vinyl silicone rubber. Among the five vinyl-polysiloxane impression materials, Hydrophilic Exaflex produced the least porosity. 2. Porosity in casts made with Provil tended to decrease definitely as pouring time progressed. This tendency occurred with no other materials. 3. When the die material was mixed at a low water-powder ratio, cast-surface porosity was reduced in the case of all materials except President. 4. Concentration of hydrogen gas, which was released from all vinyl-polysiloxane impression materials, decreased with the passing of time. 5. In the case of Provil, a correlation existed between hydrogen-gas concentration and the degree of cast-surface porosity. But no similar correlation was observed in the case of any other vinyl-polysiloxane impression materials.

Dental Impression Materials↗
PubMed1990

[Corrosion of dental titanium alloys binary system of Ti-Al, Ti-Cu, Ti-Ni].

Anodic polarization, natural electrode potential, polarization resistance, tarnish, weight change and metal component dissolution in artificial saliva, of Ti-Al, Ti-Cu and Ti-Ni binary alloys were investigated to determine the effects of the added elements on the corrosion characteristics. In the case of Ti-5 at % Al to Ti-50 at % Al system alloys, increase in the aluminum content of the alloys raised the corrosion resistance. However pitting corrosion presumed at an aluminum content of more than 10 at %. In the case of the Ti-5 at % Cu to Ti-70 at % Cu system alloys, increase in the copper content of the alloys decreased the corrosion resistance and the decrease was marked at a copper content of more than 50 at %. In the case of Ti-5 at % Ni to Ti-70 at % Ni system alloys, 50 at % Ni was estimated to be the maximum content to keep corrosion resistance of the titanium alloys.

Aluminum↗
PubMed1989

[The usefulness of Chlamydia testpack for the diagnosis of Chlamydia trachomatis infection in genito-urinary tract].

A comparative study between Chlamydia Testpack and Chlamydiazyme for the detection of chlamydial antigen was performed. In 61 cases suspected of being chlamydial infection, Chlamydia Testpack had a specificity of 92% and a sensitivity of 88% when compared with Chlamydiazyme. On the result of study using Chlamydia trachomatis serotype B, the sensitivity of Chlamydia Testpack which had a lower limit of 6 x 10(4)/ml of EB was less than that of Chlamydiazyme which had a lower limit of 0.7 x 10(4). However, the large number of EB presented in almost all positive specimen, indicated that Chlamydia Testpack could be used to screen the clinical materials.

Adolescent↗
PubMed1989

[Adult T-cell leukemia with vertebral bone tumor and acute transverse myelopathy].

We describe a case of adult T-cell leukemia (ATL) with vertebral bone invasion, who developed acute paraplegia and responded well to irradiation and combined chemotherapy. A 36-year-old man born in Tsushima Island was admitted to our hospital in May 1987, because of a sudden onset of paraplegia, hypesthesia below the level of 7th thoracic vertebra and vesicorectal disturbance. The white blood cell count was 9,500/microliter with 16% of abnormal lymphocytes showing lobulated nuclei. The surface marker analysis revealed that CD3, CD4, CD8 and CD25 positive cells were 88.1, 83.9, 6.4 and 1.3% of the peripheral mononuclear cells, respectively. Anti-ATLA antibody was positive. Serum calcium level was elevated. Bone scintigraphy showed multiple vertebral bone lesions. Vertebral bone mass and a compressed spinal cord in the 7th thoracic level were confirmed by CT scanning and MR imaging. Cerebral spinal fluid was negative for tumor cells. A diagnosis of ATL was made. Irradiation and combination chemotherapy improved bone lesions and neurological signs and the disease was well controlled by maintenance chemotherapy up to the present (August, 1988).

Acute Disease↗
PubMed1988

Changes in muscarinic receptors and amylase secretion in regenerating acinar cells of rat pancreas.

Atrophic pancreatic acinar cells of copper-deficient rats recovered after copper supplementation. To clarify whether the recovered cells are regenerative and amylase secretion via muscarinic receptors alters, [3H]-thymidine uptake, [3H]-quinuclidinyl benzilate binding and amylase release were studied in these rats and compared with the values of 5-day-old and 21-week-old rats. The [3H]-thymidine uptake study indicated that the recovered acinar cells were regenerative. The number of muscarinic receptors in regenerating cells was equal to that in mature cells and was one third in cells of 5-day-old rats. The apparent dissociation constant of muscarinic receptors was about 0.73 x 10(-10) M for the regenerating cells, 0.65 x 10(-10) M for 5-day-old rats, and 1.70 x 10(-10) M for 21-week-old rats. Amylase release, as a percent of total amylase, was maintained relatively steady in spite of the low amylase content in regenerating cells. These observations suggest that the affinity of muscarinic receptors increases to compensate the impaired amylase synthesis in regenerating acinar cells and that their amylase secretion via muscarinic receptors is different from that in 5-day-old or mature rats.

Amylases↗
PubMed1987

Morphological and biochemical changes in the pancreas of copper-deficient rats.

Two types of experimental chronic pancreatic damage were induced in rats by a copper-deficient diet containing D-penicillamine (DP rats) and by a similar diet without D-penicillamine (D rats). At 5-6 weeks after commencement of treatment, serum copper levels showed a significant decrease in both DP rats (1.5 +/- 0.9 micrograms/dl, M +/- SE) and D rats (18.8 +/- 1.4 micrograms/dl) compared with the findings in control rats (111.8 +/- 4.4 micrograms/dl). Histology revealed loss and atrophy of acinar cells in DP rats and mild vacuolar degeneration of acinar cells in D rats, whereas the islets of Langerhans were intact in both groups. The secretion of the exocrine pancreas showed a marked decrease in enzymes and protein output in DP and D rats compared with findings in the control rats. Our study confirmed the relationships between serum copper levels and morphological damage of pancreatic acinar cells or the reduction of enzyme secretion. On the other hand, the reductions in volume and bicarbonate output of pancreatic juice in DP rats and in D rats were detected, but no relationship was found between these reductions and the serum copper levels. The endocrine pancreatic function in DP rats showed a slight disturbance in intravenous glucose tolerance test. These results support the conclusion that copper-deficiency causes disturbances in enzyme-synthesis and selective destruction of acinar cells.

Animals↗
PubMed1987

Colonization with genital mycoplasmas in pregnant women and their neonates and birth weight.

The colonization by genital mycoplasmas of mothers and their newborn infants was examined in 114 pregnant women and their 84 neonates. Urine and cervical swabs were taken from the pregnant women in the last trimester, and urine from the neonates within six days after birth. Ureaplasma urealyticum was found in 73.7% of the pregnant women and in 17.9% of the neonates. Mycoplasma hominis was isolated in 8.8% of the material from the pregnant women and in 1.2% of that from the neonates. The isolation rate of U. urealyticum from newborn girls was significantly higher than that from newborn boys (p less than 0.01). There was no correlation between the germ density in the urine of the pregnant women and that of the neonates. The urine of the neonates harboured as many U. urealyticum as that of the adults. The frequency of colonization by mycoplasmas in the pregnant women or the neonates was not related to the duration of gestation or the babies' birth weight.

Adult↗