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Biomedical subjects

T Szmolenszky

Publications and source records attributed to T Szmolenszky.

At least 19 recordsLinked to original sources
PubMed1989

Longitudinal and vertical ultrastructural lesion of crural muscle in post-thrombotic syndrome.

The vertical and longitudinal ultrastructural changes of the crural muscle (triceps surae) were studied in a selected patient material of 18 patients suffering from post-thrombotic syndrome. The transmission and scanning electron microscopic method helped in revealing that the damage had affected the contractile system, the mitochondria and the endoplasmic reticulum and in addition marked degenerative phenomena occurred. It was shown that vertically the impairments of the fine structure were localized in foci and involved the muscle layers to the same extent. Longitudinally--distally--the muscle changes displayed an increasingly aggravating diffuse appearance. Of the several factors responsible for the development of the pathological ultrastructural picture, tissue hypoxia and metabolic disorder, as well as a decreased microcirculation (hypoperfusion) and chronic inactivity are to be emphasized.

Adult↗
PubMed1984

Ultrastructural damage of crural muscle in post-thrombotic syndrome.

The fine structure of crural muscles in 11 patients suffering from post-thrombotic syndrome was investigated. The contractile elements and the mitochondria were mainly involved in the pathological changes. Glycogen granules in increased number and strong lipid vacuolization were shown. The focal occurrence of damages has to be emphasized. Beside, ultrastructural changes are induced by hypoxia and by other factors. It can be established that limited functional capacity of the lower extremities in post-thrombotic syndrome is due not only to chronic haemodynamic insufficiency but to the serious fine-structural damage.

Adult↗
PubMed1980

Ultrastructural features of canine kidneys after preservation with hyperthermic solutions and subsequent reperfusion.

An analysis of the ultrastructural features of 35 canine kidneys after hypothermic preservation in Rheomacrodex, Collins3 and Sacks II solutions, and subsequent autologous reperfusion for 2 to 3 hours is presented. Signs of irreversibility (intramitochondrial crista fragmentation, cell membrane rupture, detachment of the brush borders in the area of the proximal tubular system) were confined to the Rheomacrodex-preserved kidneys. Other abnormal features (cytoplasmic vacuolation, mitochondrial swelling in the proximal tubules, vacuolation of the visceral epithelial cells, heteromorphism in the glomerular system) found in the acute stage of revascularization may be regarded as reversible and account for the transitory functional disorders of renal transplants.

Animals↗
PubMed1980

[Value of organ preservation with Collins-3 and Sacks II solutions of warm ischemic and re-perfused kidneys].

The protective effect of Collins or Sacks solutions was reduced after warm ischemia in preserved and reperfused dog kidneys. The degree of the developed pathologic alterations was connected with the length of the warm ischemic period. Functional changes as decrease of microcirculation and proteinuria and structural sequences as edema and diverse disintegration in glomeruli and tubuli were produced.

Animals↗
PubMed1980

[Susceptibility of the myocardium to injury in decreased coronary circulation].

In the experiments intact dog hearts with ligated descendents, hearts with aorta insufficiency and others with a cardiopulmonary bypass were perfused. It was demonstrated that both ischaemia and relative oxygen deficiency induce within a comparatively short time the same type of irreversible damage in the structure of the subendocardial layers of the myocardium (lysis and rupture of the myofilament, swelling of the mitochondrium, rupture and lysis of the crista, clearing of the matrix). Consequently, the aimed protection of the myocardium during cardiac surgery is of the greatest importance.

Animals↗
PubMed1979

The aminogram of the urine produced by the preserved kidney.

The function of autogenous canine kidneys may be considered even after successful preservation and reperfusion to be pathological for about 3 to 4 days, since a condition characterized by proteinuria and increased amino aciduria exists for a while.

Amino Acids↗
PubMed1979

Description and interpretation of morphological changes in canine kidneys after preservation with hypothermic solutions and subsequent reperfusion.

The morphological appearance of canine kidneys preserved with hypothermic solutions of three different types (Rheomacrodex, Collins 3 and Sacks-II) was studied in acute autologous reperfusion models. While at the end of preservation the renal structure still seemed intact (with the exception of the Rheomacrodex model), reperfusion was associated with the manifestation of hitherto latent structural lesions. This is confirmed by light-microscopic features (hydropic swelling and destruction of the tubular epithelium), enzyme histochemical studies (positive alkaline phosphatase reaction of the Bowman space) and topo-optical reactions (loss of anisotropy of the cytomembranes in the presence of fairly well preserved birefringence of the basement membranes).

Animals↗
PubMed1979

Consequences of experimental mitral insufficiency induced by chordotomy.

In mitral insufficiency induced by chordotomy in dogs beside the common diagnostic data the values for tissue perfusion indicative of myocardial microcirculation have been studied. Unexpectedly, a decrease of subendocardial circulation was found; this reduced circulation manifested itself with alterations such as changes in mitochondrial structure, increased quantity of subsarcolemic sarcoplasma, and degenerative symptoms.

Animals↗
PubMed1978

Description and interpretation of functional changes in canine kidneys after preservation with hypothermic perfusates and subsequent reperfusion.

The function of canine kidneys stored with hypothermic solutions (Rheomacrodex, Collins4, Sacks) was studied in acute autologous reperfusion models. Changes in the perfusates (increase in LDH level and minor increase in K+ level), as well as the quantitative and qualitative properties (proteinuria) of the urine produced by the graft may be ascribed to storage and revascularization which affect the cells and their membranes. The alterations of the circulatory parameters demonstrable at the outset and during revascularization are due to an increase in renovascular resistance of hypothermic origin on the one hand, and to acute tubular epithelial damage inherent in the procedure, on the other.

Animals↗
PubMed1978

The donor kidney: I. Morphology of adequate preservation.

The structure of the dog kidney can be preserved in hypothermic intracellular-type solutions, but after 6 hours the appearance of pathologic focal changes such as mild oedema, lesions of the cellular elements, podocyte heteromorphism, vacuolization, disintegration of the basal membrane and of the cytomembrane structrues and even cell degeneration, is unavoidable.

Alkaline Phosphatase↗
PubMed1978

Flow and myocardial microcirculation after experimental mammary-coronary bypass.

The functional capacity of mammary-coronary bypass was assessed in acute dog experiments by means of electromagnetic flow measurement and estimation of myocardial flow by hydrogen polarography. 1)In the intact myocardium the central flow of the mammary-coronary bypass and the tissue perfusion provided by its correspondence to the functional capacity of the intact anterior descending coronary; 2) despite an unchanged perfusion pressure the myocardium damaged by infarction is no longer able to take up the available quantity of blood, and both flow and tissue perfusion decrease; 3) the reactive hyperaemia induced by ischaemia considerably reduces the microcirculation of the damaged myocardial tissue.

Animals↗
PubMed1977

Description and interpretation of structural changes in canine kidneys after preservation with a hyperosmolar solution and reperfusion.

The effects of hypothermic preservation of canine kidneys for 24 hours by the use of the Sacks solution, and additional autogenous reperfusion were studied by means of submicroscopic morphological methods. While preservation with the Sacks solution was to ensure normal organization of the lipoprotein structures of the basement and cell membranes, in case of additional reperfusion, even of short duration, a substantial or complete loss of anisotropy of the cytomembranes was demonstrable. The present report is the first to be published in the literature on polarization microscopic studies concerned with the effects of kidney preservation and of reperfusion.

Animals↗
PubMed1976

Characteristics of hyperacute rejection of swine kidney xenografts perfused with canine blood.

Twenty-five swine kidney xenografts previously flushed with Collins-4 solution were perfused with canine blood and the functional and morphological changes resulting from xenoperfusion were studied. Blood flow of the kidneys practically ceased by the end of 8 minutes parallel with progressive swelling and cyanosis of the organ. Microscopic study of the kidneys revealed gross destruction of the glomerular and tubular apparatus, marked by extensive oedema, interstitial haemorrhages, diffuse capillary thrombosis and damage to the cell membrane.

Animals↗
PubMed1976

[Auto-perfused multi-organ preparations. III. Interpretation of histologic changes in perfused organs].

The functional instability of "multi-organ" preparations has been studied by morphological and histochemical assessment of 46 autoperfused heart-lung-kidney-liver-duodenopancreas preparations. The organs of the autoperfused preparations were damaged to different degrees, but the damage was always a function of perfusion time (1 to 3 hours). The liver suffered the most serious lesions (stagnation, oedema, hepatocytolysis, hydropic degeneration) but lesions such as interstitial haemorrhage and oedema though in a milder form appeared also in the kidney. The heart structure was comparatively well preserved.

Animals↗
PubMed1976

Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs in the course of administration.

Cerebral, myocardial and renal capillary flow rate was significantly increased by 10 to 20 mug/kg/min doses of ethyl apovincaminate (RGH-4405, Cavinton) injected in slow infusion to dogs. These effects were long-lasting. Since perfusion pressure and heart rate were not affected by the compound, it was concluded that increased flow rate was attributable to decrease of peripheral vascular resistance. Results indicate that Cavinton has a vasodilatory effect.

Animals↗
PubMed1976

Viability of extracorporeally perfused dog livers.

The possibility of structural and functional preservation of the isolated liver has been studied in dog experiments. A sterile liver preparation left in situ was worked out, having practically no ischaemic period, except during perfusion. Nevertheless, well-defined lesions (perivascular and interstitial oedema, dissociated contraction of the smooth muscle elements of the veins, cellula accumulation in the sinusoids) appeared, accompanied by a gradual reduction (microcirculatory disorders, enzyme derailment) of the function of hepatocytes.

Animals↗
PubMed1975

Autoperfused multi-organ preparations. II. Microcirculation in the autoperfused organs.

The microcirculation of 46 autoperfused heart-lung-liver-duodenum-pancreas-kidney preparations has been studied and the acid-base conditions were determined. The stability of the autoperfused organ preparation was not ensured by the "multi-organ" arrangement, moreover the combination had a detrimental effect, with reduced tissue perfusion leading to hypoxia and acidosis. This general vasomotor breakdown represented a therapeutic drug resistance, so that the organ preparation failed to solve the problem of temporary organ preservation.

Animals↗