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T T Provost

Publications and source records attributed to T T Provost.

125 records · Page 7Linked to original sources
PubMed1973

Evidence for complement activation via the alternate pathway in skin diseases, I. Herpes gestationis, systemic lupus erythematosus, and bullous pemphigoid.

A patient with herpes gestationis, 6 of 6 patients with bullous pemphigoid, and 5 of 25 patients with systemic lupus erythematosus were found to have properdin deposited along the skin basement membrane.The patient with herpes gestationis demonstrated by immunofluorescence basement membrane deposition of C3 and C5 in the absence of C1q, immunoglobulins, and light chains. A second patient with herpes gestationis had C3 deposition with no demonstrable immunoglobulins or light chains. A thermolabile humoral factor(s) capable of depositing C3 (without C1q or C4) on normal skin basement membrane was found in the sera of both patients with herpes gestationis. No anti-basement membrane antibodies could be demonstrated in the sera of these patients.The patients with systemic lupus erythematosus and bullous pemphigoid who manifested properdin deposition also showed skin basement membrane deposits of C1q, C4, C3, C5, and immunoglobulins. C3 proactivator (C3PA) was also found deposited along the skin basement membrane of three patients with systemic lupus erythematosus and all six bullous pemphigoid patients. This study provides suggestive evidence that activation of complement is occurring via the alternate pathway in herpes gestationis. In systemic lupus erythematosus and bullous pemphigoid, both the classical (antibody) mediated activation of complement as well as the alternate pathway may be operative.

Adult↗
PubMedDate not supplied

Antibodies to cytoplasmic antigens in lupus erythematosus. Serologic marker for systemic disease.

Seven patients with classic cutaneous lupus erythematosus are described. Three of these patients had features satisfying four of the American Rheumatism Association (ARA) preliminary criteria for the diagnosis of systemic lupus erythematosus (SLE). Their sera, however, lacked antinuclear antibodies but demonstrated precipitating antibodies reactive against cytoplasmic RNP (La) and non-nucleic acid (Ro) antigens. Four additional ANA-negative patients lacking significant skin disease but having a lupus-like multisystem disease were found to have antibodies to soluble cytoplasmic antigens. Thirty-three of 130 ANA-positive SLE patients, but none of 16 discoid lupus patients, possessed these anticytoplasmic antibodies. These findings suggest that antibodies to Ro and La may be a marker for systemic disease in ANA-negative patients with 1) cutaneous lupus and 2) a distinct subpopulation of patients with a lupus-like syndrome without skin disease.

Adolescent↗
PubMedDate not supplied

Serum autoantibodies in systemic lupus erythematosus and correlation with cutaneous features.

Eighty-eight untreated systemic lupus erythematosus patients collected from rheumatology services were studied for the presence of discoid, molar and vasculitic lesions and photosensitivity. Their sera were examined for antibodies to native deoxyribonucleic acid (nDNA), nuclear ribonuclear protein (nRNP), the non-nucleic acid nuclear macromolecule Sm, the nuclear and cytoplasmic macromolecules La(SSB) and the predominantly cytoplasmic macromolecule Ro(SSA). These studies demonstrated that 42% of the lupus patients possessed nDNA; 36% nRNP; 24% Ro(SSA) and 9% anti La(SSB) antibodies. Six patients failed to demonstrate significant antinuclear antibody titers (mouse liver substrate), and 4 of these possessed anti Ro(SSA) antibodies. Correlation to the cutaneous lesions among this lupus population possessing various serum antibodies revealed a trend toward photosensitivity and molar dermatitis in the Ro(SSA), La(SSB), Ro/la and the ANA negative, ANA negative/Ro positive groups of lupus patients.

Antibodies, Antinuclear↗
PubMedDate not supplied

Ro(SSA) and La(SSB) antibodies in the clinical spectrum of Sjögren's syndrome.

Seventy-five patients with the symptomatic sicca complex were evaluated clinically and classified as having Sjögren's syndrome (SS) alone or the sicca complex associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS) or another connective tissue disorder. Their status with respect to anti-Ro(SSA)/La(SSB) antibodies was determined independent of clinical evaluation and categorization. Overall, 33 (44%) were found to have antibodies to Ro(SSA); and 12 (16%) had antibodies to La(SSB). Anti-Ro antibodies occurred in 50% of those with SS alone as well as in SS associated with RA (39%), SLE (58%), and PSS (20%). Furthermore, patients with SLE without the sicca complex demonstrated antibodies to Ro(SSA) (24%) and La(SSB) (5%). A striking association of anti-Ro(SSA) antibodies in SS with vasculitis is described.

Antibodies↗
PubMedDate not supplied

The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases.

Seventy-two patients were studied whose sera contained antibodies to a cytoplasmic antigen, RO. The majority had clinical features typical of systemic lupus erythematosus and there appeared to be an overlap with Sjögren's syndrome. Of interest is that certain patients with lupus respond predominantly to cytoplasmic antigens and in some cases were ANA negative. Demonstration of this system is important in enlarging the serologic spectrum characteristic of SLE patients, and also may be an important marker for systemic disease in patients with predominantly cutaneous involvement.

Antibodies, Antinuclear↗