Experimental enteritis produced by high environmental temperature.
The authors exposed groups of Wistar rats of different average body weight to elevated environmental temperature. Necrotizing enteritis-like changes developed in the majority (up to 85%) of the animals. The best results were found in the group treated for 20 minutes at 45 degrees C, 20 minutes at rest, and 20 minutes at 56 degrees C. Subnuclear vacuolization of the enterocytes on the top of the villi intestinalis seems to be the initial event followed by subepithelial cleft formation, lifting and shedding of the epithelial cells, infiltration of the stroma by active phagocytes, and autolysis. Changes of the mesenteric blood flow can play a crucial role in the development of these lesions.
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