Biomedical subjects
Publications and source records attributed to T Tamura.
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Cycloartenol and cycloartanol are the major components of the 4,4-dimethylsterol fraction separated from the seeds of red pepper (Capsicum annuum, Solanaceae). Lanosterol and lanostenol, whose occurrence in higher plants has hitherto been known as extremely rare, are identified in the fraction by gas liquid chromatography, combined gas liquid chromatography-mass spectrometry, and isolation as their epoxides.
Thirteen 4-desmethylsterols: cholesterol, 24-methylcholesterol, 24-ethylcholesterol, stigmasterol, 24-methylcholesta-5,24-dienol, 24-ethylcholesta-5,24-dienol, 28-isofucosterol, 24-methylenecholesterol, cholestanol, 24-methylcholestanol, 24-ethylcholestanol, cholest-7-enol and 24-ethylcholest-22-enol, were identified in the seeds of solanaceous plants. The distribution of these 4-demethylsterols in the seeds of eleven plants among seven genera of the Solanaceae family was determined.
The proton magnetic resonance (PMR) spectra were measured in deuterochloroform (CDC13) and pyridine solutions for some 4-desmethyl, 4alpha-methyl, 4beta-methyl, and 4,4-dimethyl sterols related to 5alpha-cholestane series as well as for their C-3-oxo derivatives. The influence of pyridine, relative to CDC13, on methyl group chemical shifts was discusssed. The technique utilizing pyridine-induced solvent shifts in PMR spectroscopy was found useful in characterizing the individual classes of sterols.
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A persisting type of infection with wasting syndrome was established in congenitally athymic nude mice after intraperitoneal inoculation with a mouse hepatitis virus which was not fully pathogenic for heterozygous haired littermates. From the liver, spleen, lymph nodes, and brain of most infected nude mice, the virus was detected at high titers during aperiod from 6 to 35 days postinfection, occurrence of degenerative and necrotic lesions being correlated with virus titers in these organs. The titer of serum neutralizing antibody remained undetectable or very low in most diseases nude mice, whereas some animals resisting the infection could produce antibody at a later stage. In heterozygous haired mice, some lesions were detectable at a very early stage of infection in the spleen and liver, but they seemed to disappear with a marked elevation of the neutralizing antibody titer. Nude mice were able to resist the virus infection when they had previously received transfer of thymocytes from weanling heterozygous littermates.
Major and minor axes of the left ventricle were measured by single beam echocardiography in ten cardiac patients and the measurements and calculated volumes by formula V=pi/6 D2 were compared with the angiocardiographic estimates. There was a favorable correlation between echocardiographic and angiocardiographic major axis dimention (r=0.79), left end-diastolic volume (r=0.96), and ejection fraction (r=0.81). On the contrary, left end-diastolic volume calculated by formula V=D3 was less correlated with angiocardiographic estimates (r=0.93) and the former had a tendency to overestimate the volumes where D exceeded 6.5 cm. These data indicate that in cases with markedly enlarged left ventricle, the use of formula V=pi/6 D2L is a more accurate predictor of volumes than formula V=D3.
Nude (nu/nu) mice fail to resist to challenge infection of Tyzzer's disease after pretreatment with formalin-killed organisms that was effective for protecting heterozygous haired (nu/ł) mice from challenge. Resistance was induced nu/nu mice after the transfer of spleen cells from immunized nu/ł and concomitant formalin vaccine treatment.
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