[Basis of kidney function tests. (4) Correlation between morphological and functional changes. (in glomerulonephritis)].
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Biomedical subjects
Publications and source records attributed to T Tamura.
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Chronic active hepatitis was produced in nude mice after inoculation with a mouse hepatitis virus from a natural nude case which was incapable of causing fatal infection in haired heterozygous mice without cortisone. Survival time of infected nude mice varied greatly from 1 to 10 weeks after the inoculation. Degeneration and necrosis of hepatocytes, apparition of small and megalocytic hepatocytes, and infiltration of lymphocytes and plasma cells with fibrosis, were most remarkable in those which died 3 weeks or more after inoculation. No such severe hepatic lesions were recognized in heterozygous haired litter-mates after inoculation of the same virus. Necrotic lesions with poor inflammatory reactions were seen in the brain of all infected and dead nude mice, while some cerebral lesions with apparent perivascular infiltration were detected in heterozygous ones only at early stage of infection.
Nude (nu/nu) mice failed to resist to virulent mouse hepatitis virus (MHV) infection after vaccination with inactivated virus. Resistance was induced in nu/nu mice by the transfer of spleen cells from heterozygous haired (nu/ +) mice concomitantly with the vaccination, and the effect was more remarkable with spleen cells from immunized nu/ + mice. Antibody was demonstrable in nu/nu mice having received nu/ + cells and survived challenge infection.
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A new triterpene alcohol was isolated from shea butter and its structure was shown to be 24-methylenedammarenol (24-methylene-5alpha-dammar-20[21]-en-3beta-o1). Dammaradienol (5alpha-dammara-20[21],24-dien-3beta-o1) also was isolated from shea butter.
A new triterpene alcohol was isolated fron shea butter and its structure was shown to be 24-methylenelanost-9(11)-en-3beta-ol. Gas chromatographic correlations between this triterpene alcohol and other related compounds are discussed.