PubMed Health⌕ Search

Biomedical subjects

T Tamura

Publications and source records attributed to T Tamura.

At least 1,459 records · Page 81Linked to original sources

Response of nude mice to a mouse hepatitis virus isolated from a wasting nude mouse.

Chronic active hepatitis was produced in nude mice after inoculation with a mouse hepatitis virus from a natural nude case which was incapable of causing fatal infection in haired heterozygous mice without cortisone. Survival time of infected nude mice varied greatly from 1 to 10 weeks after the inoculation. Degeneration and necrosis of hepatocytes, apparition of small and megalocytic hepatocytes, and infiltration of lymphocytes and plasma cells with fibrosis, were most remarkable in those which died 3 weeks or more after inoculation. No such severe hepatic lesions were recognized in heterozygous haired litter-mates after inoculation of the same virus. Necrotic lesions with poor inflammatory reactions were seen in the brain of all infected and dead nude mice, while some cerebral lesions with apparent perivascular infiltration were detected in heterozygous ones only at early stage of infection.

Animals↗

[Immunization of the nude mouse against mouse hepatitis virus through the transfer of sensitized lymphocytes].

Nude (nu/nu) mice failed to resist to virulent mouse hepatitis virus (MHV) infection after vaccination with inactivated virus. Resistance was induced in nu/nu mice by the transfer of spleen cells from heterozygous haired (nu/ +) mice concomitantly with the vaccination, and the effect was more remarkable with spleen cells from immunized nu/ + mice. Antibody was demonstrable in nu/nu mice having received nu/ + cells and survived challenge infection.

Animals↗

24-Methylenedammarenol: a new triterpene alcohol from shea butter.

A new triterpene alcohol was isolated from shea butter and its structure was shown to be 24-methylenedammarenol (24-methylene-5alpha-dammar-20[21]-en-3beta-o1). Dammaradienol (5alpha-dammara-20[21],24-dien-3beta-o1) also was isolated from shea butter.

Chemical Phenomena↗