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T Tazawa

Publications and source records attributed to T Tazawa.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Dynamic pathophysiology of cerebral infarction and revascularization. I. Ischemic cerebral edema].

A natural history of ischemic cerebral edema was analyzed in 100 patients with occlusive cerebrovascular diseases admitted within one week of onset, with serial computed tomography (CT) and angiograms. Cerebral edema was defined as a low-density area with mass sign on CT. A total of 446 studies of CT were performed. In 40 patients with major completed stroke admitted 24 hours of onset, a total of 73 studies of CT were taken within 48 hours of onset, and a timing of appearance of cerebral edema was analyzed. Patients were allocated to two groups according to the findings on angiograms; 68 patients who showed occlusive lesions on sequential angiograms (the group of no-recanalization), and 32 patients who showed reopening of occluded vessels on the first or sequential angiograms (the group of no-recanalization). In the group of no-recanalization a low-density area gradually appeared between 6 and 24 hours of onset A. mass sign reached its peak on the 3rd day with a peak incidence of 56%, and midline shift was present in 30% of the cases. It was resolved within 2 weeks in most cases. In the group of recanalization, a low density area appeared after 4 hours and rapidly increase after 6 hours. All patients had a low-density area at 12 hours of onset. A mass sign progressed until the 6th day with a peak incidence of 82%, and midline shift was present in 50% of the cases. The duration of mass sign was longer than that in the group of no-recanalization. These results suggest that the permissible duration of ischemia is considered to be within 6 hours of onset in profound ischemia. After 6 hours, ischemic tissue damage may not be reversible by the revascularization, even if CT shows no change during ischemia. An abrupt revascularization may not contribute to the recovery of brain damage, but accelerate the ischemic cerebral edema.

Aged↗
PubMed1981

[Angiographic vasospasm and regional cerebral blood flow in the cases of ruptured aneurysm --Correlation between vasospasm in the middle cerebral artery and delayed ischemic hemiparesis (author's transl)].

It is well known that the vasospasm following rupture of aneurysm causes ischemic neurological symptoms. However, there are a few literatures which refer to the relationship between the severity of angiographic vasospasm and regional cerebral blood flow (rCBF) and ischemic neurological symptoms. To elucidate this problem, 41 patients with ruptured aneurysm were analysed by means of repeated cerebral angiography and rCBF study, and the following results were obtained. 1. Mean rCBF was reduced to its lowest level in the second week of hemorrhage and at this stage, the values of mean rCBF were well correlated with the severity of the angiographic vasospasm and with the development of delayed ischemic neurological symptoms. 2. The morphological feature of the angiographic vasospasm was a smooth narrowing of the vessels, and the delayed ischemic hemiparesis occurred when both M-1 and M-2 portions of the middle cerebral artery are narrowed more than half comparing the calibers as seen within 3 days of hemorrhage. 3. The average of mean rCBF in 15 patients with symptomatic spasm was 27.0 +/- 5.5 ml/100 g/min. and that in 11 patients with asymptomatic spasm was 40.8 +/- 8.8 ml/100 g/min. As a conclusion, the prognosis of the patients with angiographic vasospasm may be predicted through the value of rCBF and the severity of angiographic vasospasm in the second week of hemorrhage.

Adult↗
PubMed1980

Intensified cancer themotherapy by induction of hepatic drug-metabolizing enzymes as a trial for the treatment for stomach cancer.

Studies of an intensified chemotherapy of FT-207, combined with MMC, have been under way since April 1977 in the First Department of Surgery of Chiba University Hospital and five closely related hospitals. These studies were performed on 114 patients with curative stomach cancer. The 114 patients received intravenously 0.4 mg/kg and 0.2 mg/kg of MMC on the operation day and the next day, respectively, and then intravenously 800 mg of FT-207 daily from the 10th postoperative day until discharge, followed by oral administration of FT-207, 600 mg, for more than 1 year after discharge. The 114 patients were divided into two groups. Half of the patients received 100 mg of phenobarbital and 30 mg/kg of glutathione for the purpose of induction of hepatic drug-metabolizing enzymes (induction group). Significantly higher levels of serum 5-FU released from FT-207 were observed in the patients of the induction group when compared to those of the control group. However, there was no statistically significant difference in survivals at both 12 and 24 months after operation between both groups.

Drug Therapy, Combination↗
PubMed1980

Value of computed tomography in the prediction of cerebral vasospasm after aneurysm rupture.

The relationship between high density (HD) on computed tomographic (CT) scans (which indicates a collection of blood in the subarachnoid space) and cerebral vasospasm was studied in 177 patients with ruptured aneurysm. The development of cerebral vasospasm was confirmed at the high rate of 84.6% in 26 cases where HD was demonstrated on the CT scan within 4 days after subarachnoid hemorrhage (SAH). In 8 cases where HD was not found on the CT scan obtained within 4 days after SAH, no cerebral vasospasm was seen. However, no relationship was found between HD and the occurrence of cerebral vasospasm in cases in which CT was performed after the 5th day of disease. It is suggested that CT performed within 4 days after SAH may give important information for predicting cerebral vasospasm.

Adult↗