Biomedical subjects

T Teshirogi

Publications and source records attributed to T Teshirogi.

17 recordsLinked to original sources

PubMed1992

[Studies on insulin secretion and clearance in obese and diabetic children (7-11 years old) and adolescents (12-16 years old) investigation by oral glucose tolerance tests (O-GTT)].

We analyzed O-GTT obtained from 375 children (group A; 7-11 years old) and adolescents (group B; 12-16 years old), including 96 normal non-obese cases, 266 simple obese cases (172 with normal O-GTT, 79 with border line type O-GTT and 15 with diabetic type O-GTT), 8 obese NIDDM cases and 5 non-obese NIDDM cases. The results were as follows; 1) The levels of epsilon CPR (in terms of total sum of the values measured at 0, 30, 60, 120 and 180 minutes on O-GTT) in the obese children and adolescents were only 1.5 and 1.2 times as high as in the control group. The levels of epsilon CPR/epsilon IRI molar ratio in the control group were 2.0 and 2.3 times as high as in the obese children and adolescents. These data suggest that hyperinsulinemia in the obese children and adolescents is caused mainly by decreased hepatic insulin extraction rather than by increased insulin secretion. 2) In the non-obese NIDDM adolescents, the levels of epsilon CPR decreased to about 3/4 of those in the control group; in contrast, the epsilon CPR/epsilon IRI molar ratio increased. Therefore, it seems that there is increased hepatic insulin extraction as well as decreased insulin secretion in the non-obese NIDDM adolescents. 3) In the obese NIDDM adolescents, the levels of epsilon CPR were nearly the same as in the control group and the epsilon CPR/epsilon IRI molar ratios were slightly lower as the disease state of NIDDM counterbalanced obesity.

Adolescent↗

PubMed1991

[The significance of serum gamma-glutamyl transpeptidase (gamma-GTP) elevation caused by antiepileptic drug(s). Using the antipyrine metabolic capacity as a parameter of microsomal enzyme activity].

Of 242 patients who were given antiepileptic drugs (AEDs), 40 exhibited a high level of serum gamma-glutamyl transpeptidase (gamma-GPT). The significance of the high level was examined. "Antipyrine test" was also performed on 9 healthy controls and 39 patients with AEDs administration, and the antipyrine half-life (APt 1/2), a reliable index for hepatic microsomal enzyme activity (MEA), was calculated for each subject. A high level of serum gamma-GTP occurred more frequently in phenytoin (PHT) administered group than in PHT non-administered group. Furthermore, the maximum level was significantly higher in the former than in the latter. In 17 out of the 40 cases, the serum gamma-GTP level was decreased to a normal level without reducing AED doses or stopping the AED administration, or changing to different AEDs. On the other hand, in almost all cases with AED administration, APt 1/2 was shortened (i.e., induction of the microsomal enzyme). Furthermore, there was no correlation between serum gamma-GTP level and APt 1/2 in the cases with AED administration, indicating that the serum gamma-GTP level was not a proper index for MEA. It was also shown that phenobarbital, PHT and carbamazepine, each being used alone within the therapeutic dose, could cause almost the maximal degree of hepatic microsomal enzyme induction. Thus it is suggested that the elevation of serum gamma-GTP level due to AED does not necessarily indicate hepatocellular damages. If this is accepted, it follows that even if patients with AED administration have a high level of serum gamma-GTP, it is not necessary to reduce the AED doses, or discontinue them, or change to different AEDs.

Adolescent↗

PubMed1991

Application of improved coupling assay method for peroxidase of diseased thyroids: report of three cases.

Recently we have developed an assay method for peroxidase-catalyzed coupling of iodotyronine residues of thyroglobulin, which is applicable to human diseased thyroid tissues. In the present study, the assay method as well as usual peroxidase assay methods were applied to thyroids of three patients (No. 1: familial goiter with impaired thyroglobulin synthesis, No. 2: mild chronic thyroiditis, No. 3: dyshormonogenetic goiter) who showed organification of iodine with high TSH levels and low thyroid hormone levels in sera. In general, these patients showed relatively high activities measured by guaiacol oxidation assay, iodide oxidation and coupling assay compared with those of control thyroids. Iodothyronine content in thyroglobulin was very low except thyroxine in No. 2. These results indicate that factors other than peroxidase may be responsible for the cause of the hypothyroid state. The coupling assay method used here is therefore useful for the detection of the 'coupling defect' in patients in a hypothyroid state.

Adolescent↗

PubMed1989

The 24 h-urinary excretions of albumin, beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase activity in children with IDDM.

Microalbuminuria in diabetics is considered to be a sensitive indicator of early diabetic nephropathy. In this paper, 24 h-urinary excretions of albumin, BMG and NAG activity were measured in forty-one children with insulin-dependent diabetes mellitus. Moreover, the relationships between the urinary excretions of these substances and various clinical parameters of diabetes were analyzed. The mean values (mean +/- SD) of 24 h-urinary albumin, BMG and NAG activity in the diabetic children were 8.0 +/- 10.6 mg/day, 61.2 +/- 69.0 micrograms/day and 1.87 +/- 1.30 U/day, respectively. No significant differences were found between diabetic children and normal controls for these mean values. Nor were significant correlations between the various clinical parameters of diabetes and the urinary excretions of any of these substances found. However, nine of the forty-one diabetic children (22.0%) had higher levels of these urinary substances than those (mean + 2SD) in normal controls. Screening of the 24 h-urinary albumin, BMG and NAG activity should be performed routinely in young patients with diabetes.

Acetylglucosaminidase↗

PubMed1987