PubMed Health⌕ Search

Biomedical subjects

T Tomomitsu

Publications and source records attributed to T Tomomitsu.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Bone mineral determination using dual energy X-ray absorptiometry (DEXA)].

To quantify the appendicular and axial bone mineral with good accuracy and precision, dual energy X-ray absorptiometry (DEXA), DCS-600 (Aloka) for the radius, mainly composed of cortical bone, and QDR-1000 (Hologic) for the lumbar vertebrae, mainly composed of trabecular bone, was used. Bone loss with aging was earlier in females than that in males, and it was also more prominent in the lumbar vertebrae than that in the radius. Furthermore, the vertebral fracture rate could be evaluated by calculating percentile of an individual bone mineral density to the peak bone mass. Thus, the bone mineral determination using DEXA in both the appendicular and axial bone will provide a useful information in the assessment of bone loss, and the detection of the patients with high risk of fracture in osteoporosis.

Absorptiometry, Photon↗
PubMed1989

New perspectives for diagnosis of nodular goiter by technetium-thallium subtraction scanning.

To improve the scintigraphic differential diagnosis of thyroid nodules, Tc-99m pertechnetate-Tl-201 Cl subtraction scintigraphy (Tc-Tl subtraction scanning) was performed in 106 patients with various histologically proven thyroid nodules. Results were evaluated by comparison with surgical findings and preoperative ultrasonographic results. Thyroid nodules were more successfully detected by Tc-Tl subtraction scanning than by either Tc-99m pertechnetate or Tl-201 Cl scintigraphy alone. Detection of nodules was further improved when images recorded by the three methods were integrally observed (sensitivity 83%, accuracy 89%), with detectability approaching that of ultrasonography. False-positive or -negative Tc-Tl subtraction scans were obtained principally when multiple nodules were present (7 cases) or when no discrepancy existed between the accumulations of Tc-99m pertechnetate and Tl-201 Cl (18 cases). Most colloid nodules exhibited irregular margins, heterogeneous internal accumulations of Tl-201 Cl, and distorted shapes on Tc-Tl subtraction scans, while the majority of adenoma were oval-shaped with smooth margins. Carcinoma were characterized by homogeneous internal accumulation of Tl-201 Cl and distorted shapes.

Diagnosis, Differential↗
PubMed1989

The thallium-201 time activity curve in thyroid cancer: a role for the detection of metastases.

The Tl-201 Cl time activity curves were evaluated in 17 patients with histologically proven benign nodules and papillary carcinoma of the thyroid gland. In the dynamic studies, the uptake at the region of interest was counted every 10 sec for 20 min after the intravenous injection of 2mCi Tl-201 Cl. The curves from frame 21 to 100 were transformed to linear plots for clinical evaluation. Papillary carcinoma could not be differentiated from benign lesions by means of the values of the washout rate. However, the "relative washout rate" in papillary carcinoma was lower than that of benign lesions (P less than 0.05). Although the average values of the "relative extrapolated uptake" in papillary carcinoma appeared to be greater than those in benign lesions, the difference was not statistically significant. The difference in the washout rates between lymph node metastases and local recurrences, and pulmonary metastases of the papillary carcinoma was significant (P less than 0.05).

Adenoma↗
PubMed1989

[A case of Creutzfeldt-Jakob disease followed up by N-isopropyl-[123I]-p-iodoamphetamine and 99mTc-hexamethylpropyleneamine oxime SPECT].

N-isopropyl-[123I]-p-iodoamphetamine (123I-IMP) and 99mTc-hexamethylpropyleneamine oxime (99mTc-HM-PAO) SPECT were performed in a 66 yrs-old female patient with Creutzfeldt-Jakob disease (CJD). The decreased accumulation of both radiopharmaceuticals, which localized initially in the focal regions and progressed eventually to the whole brain, were observed in the early stage of CJD, when no abnormal findings were obtained on X-CT. Although the redistribution of 123I-IMP was recognized in the relatively early stage in which the accumulation was significantly decreased, it disappeared with the progression of the disease. The accumulation of both radiopharmaceuticals which decreased remarkably in the early stage of CJD was sustained in low level during the chronic stage. The accumulation ratio of 99mTc-HM-PAO, after second examinations, to that on first SPECT was lower than those of 123I-IMP. It was suggested, as this cause, that the difference of the accumulation mechanism of both agents might be concerned. Thus, it is interested to follow up a patient with CJD by using 123I-IMP and 99mTc-HM-PAO SPECT, and this modality will provide a useful information to clarify the pathogenesis of CJD.

Aged↗
PubMed1989

[Single photon emission computed tomography (SPECT) using 99mTc-hexamethyl propyleneamine oxime in patients with ischemic cerebral diseases: comparative study of N-isopropyl-p-[123I]-iodoamphetamine and 99mTc-DTPA SPECT].

In order to confirm the diagnosis and clarify the pathophysiology in the ischemic lesions in brain, 99mTc-PAO SPECT was performed in 42 patients with ischemic cerebral diseases, and the findings on 99mTc-PAO SPECT were compared with those on 123I-IMP or 99mTc-DTPA SPECT, and on X-CT. Furthermore, count ratio of ischemic lesion to normal contralateral region (I/N) was used for the evaluation of the detectability in the lesions on 99mTc-PAO or 123I-IMP SPECT, and less than 0.95 of I/N ratio was defined as the decreased accumulation. The detectability of ischemic lesion in brain with 99mTc-PAO SPECT was 80%, which was superior to that (60%) of LDA on X-CT. Especially, 99mTc-PAO SPECT was useful in cases which were examined early after the onset of the attack. On the other hand, 123I-IMP SPECT showed the best result (88%) in the detectability, and furthermore I/N ratio on 123I-IMP SPECT was lower than that on 99mTc-PAO SPECT. In the delayed phase on 123I-IMP SPECT the redistribution was observed in 30%, while on 99mTc-PAO SPECT it was done in none of them. The accumulation of 99mTc-DTPA in brain was found in 6 of 14 cases (43%), and 2 cases among them also showed the accumulation of 99mTc-PAO in the ischemic lesion. In such cases the destruction of BBB might be considered as the cause of the accumulation of 99mTc-PAO. Thus, 99mTc-PAO SPECT was thought to be useful method in clinical studies of the ischemic cerebral diseases.

Amphetamines↗
PubMed1989

[Single photon emission computed tomography by using N-isopropyl-p-[123I]-iodoamphetamine and 99mTc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis].

Single photon emission computed tomographies (SPECTs) by using N-isopropyl-p-[123I-IMP]-iodo-amphetamine (123I-IMP) and 99mTc-hexamethyl propyleneamine oxime (99mTc-HM-PAO) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (HSE), and the chronological changes of accumulations were studied. Accumulations of both 123I-IMP and 99mTc-HM-PAO increased initially, and then decreased with the stage of HSE being advanced. The sequential appearance of the lesion in HSE with 123I-IMP and 99mTc-HM-PAO SPECTs was as same as that reported previously by X-CT; beginning at the temporal lobe with eventually being spread to the occipital and frontal lobe. Furthermore, it was shown that findings of both SPECTs could reflect considerably the clinical features, and the laboratory data in central spinal fluid. Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.

Aged↗
PubMed1988

[Detection of varicocele by using 99mTc-diethylenetriamine pentaacetic acid human serum albumin (99mTc-DTPA human serum albumin)].

In order to detect the varicocele, scrotal scintigraphies by using 99mTc-HSA-D were performed in 14 patients with male infertile or palpable mass in left scrotum on physical examinations. Abnormal pooling of 99mTc-HSA-D, indicative of varicocele lesion, could be found in left scrotum in 9 cases, confirmed surgically or clinically. Compared with 99mTc-HSA, 99mTc-HSA-D was superior in high uptake ratio of varicocele to soft tissue and in nonvisualization of bladder. Thus, 99mTc-HSA-D scrotal scintigraphy seemed to be of a great use to detect the varicocele.

Adolescent↗
PubMed1988

[Clinical usefulness of a dual photon absorptiometry system using X-ray for peripheral bone--comparison with a single photon absorptiometric system].

A newly developed dual photon absorptiometry system (DCS-600, ALOKA Co., LTD.) using two monochromatic X-rays for the determination of bone mineral in the peripheral bone was fundamentally studied, in comparison to single photon absorptiometry system (SPA). The accuracy and precision in DCS-600 were equal to or better than SPA system. Furthermore, in DCS-600 the forearm could be imaged, and the manipulation was easy. Thus DCS-600 was found to be a good instrument as a quantifying system of bone mass.

Bone and Bones↗