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Biomedical subjects

T Ueshima

Publications and source records attributed to T Ueshima.

At least 19 recordsLinked to original sources
PubMed1998

Burns in a suicide attempt related to psychiatric side effects of interferon.

A 50-year-old woman was admitted to our critical care center after pouring lamp oil on herself and setting herself on fire. Diagnosed with chronic hepatitis, she had received interferon-alpha at another hospital. During interferon therapy she developed anxiety, irritability, sleeplessness, and depression. At our hospital she underwent fluid resuscitation according to the method of Baxter. After treatment with topical cream and ointment, she underwent skin grafting. Interferon was not given. After discharge, wound healing proved satisfactory. She was intelligent and insightful, and her mental condition remained stable with no apparent emotional problems. As she had no significant past medical or psychiatric history and no history of substance abuse, we believe that her depression was a side effect of interferon therapy. A number of reports have described depression and other psychiatric disorders associated with interferon, but none of these accounts have concerned burns sustained in suicide attempts. This case underscores the potential seriousness of adverse reactions to interferon characterized by emotional disturbance and also illustrates that physicians who treat burn patients need to have an understanding of affective disorders and unusual side effects of medication.

Antiviral Agents↗
PubMed1990

The development of the pecten oculi in the chick.

The development of the pecten oculi, a structure peculiar to the avian eye, was studied by scanning electron microscopy (SEM) correlated with light microscopy (LM) in embryonic and adult chickens. The development of the chick pecten was divided into 4 phases: (1) formation of the primordial pecten (Hamburger-Hamilton's stages 27 to 29), (2) formation of the plate-like pecten (stages 30 to 34), (3) pleat formation and pigmentation (stages 35 to 37), and (4) bridge formation and high-vascularization (stage 38 to adult). The primordial pecten is formed entirely from the ectoderm by fusion of the inwardly-projecting edges of the optic fissure. The primordial pecten grows into a tall, thin plate rising from a broad base. The pecten begins to fold slightly at stage 35. The number of pleats increases rapidly, from 7 at stage 35, to 16 at stage 36, 18 at stage 37, and 19 to 20 at stage 40. The bridge begins to form at stage 38 by a swelling of the apical edge of the pecten and completes its development by the twentieth post-hatch day. Blood vessels appear first in the broad base of the plate-like pecten, then become more numerous and gradually extend into the pleats. The pecten becomes more vascular than cellular at stage 43, and it is highly vascularized in the adult. The pleat surface becomes conspicuously irregular with increased vascularization. The peripectinate cells, located on the pecten, are already present at stage 27.

Animals↗
PubMed1990

[Evaluation of a latex agglutination method for the rapid identification of Campylobacter jejuni/coli].

A latex agglutination assay was developed to identify Campylobacter jejuni and Campylobacter coli. We evaluated the specificity, reproducibility and utility of the assay for clinical use and the following results were obtained. 1) To prepare standardized antigen, bacterial cells must be suspended to a density of 1 to 5 McFarland unit, and heated at 121 degrees C for 10 to 30 min. 2) Bacterial cells may be suspended either in the solution provided with the kit, or in physiological saline, without affecting the results. 3) Of C. jejuni, 94 strains, 6 of C. coli, and 3 of "Campylobacter upsaliensis", all tested positive without exception. All other Campylobacter species, encompassing 13 species and 80 strains, were negative. An additional 9 species and 30 strains, of non-Campylobacter gram negative bacteria, isolated on the Campylobacter selection agar medium, also were uniformly negative. Based on these results, we conclude that bacteria testing positive with the kit can be identified as C. jejuni/coli. Interestingly, "C. upsaliensis", although isolated very rarely from the clinical specimens, also tested positive.

Campylobacter↗
PubMed1988

Studies of neural tube development in the chicken embryo tail.

The tail regions of chick embryos between stages 21 to 46 were studied by light microscopy using paraffin- and epoxyembedded serial sections. The embryonic tail attains its maximum length at about stage 22. The present study examined the morphogenesis of the caudal neural tube during the reduction and remodelling processes of the embryonic tail. Between stages 21 and 28, the embryonic tail became markedly shorter, and the neural tube, with a single central canal, merged caudally with the short medullary cord and tail bud. Between stages 29 and 31, the neural tube elongated and curved rostrally, while the caudal end of the notochord and the tail bud disappeared. Between stages 32 and 39, after showing various structural changes such as dilatation or rupture and abnormal elongation of its marginal zone the neural tube became shorter. By stage 40, development of the caudal neural tube was essentially complete and the neural tube was shorter than the notochord. The neural tube opened dorsally, as in the adult chicken. The caudal opening may be newly-formed as the open portion was found to contain numerous macrophages.

Animals↗
PubMed1988

The morphological changes of the spinal motoneurons after peripheral nerve transection in the chicken.

The cellular response of motoneurons and glial cells of the chicken spinal cord was observed following brachial plexectomy. The axotomized motoneurons initially showed an irregular nuclear membrane. Subsequently, they showed the appearance of a perineuronal space and the increase in number of glycogen granules. At 10 and 20 d post-operatively, the axon reaction reached a peak and the axotomized motoneurons contained abundant glycogen granules, and tended to an increase electron density in electron microscopy or an increased basophilia in light microscopy compared to those of the control. Elongated microglial cells appeared as satellites to the axotomized cells. The perineuronal space extended with the post-operative days. From 30 post-operative days forward, the axotomized motoneurons recovered with the post-operative days. The axotomized motoneurons did not show chromatolysis during axon reaction.

Animals↗
PubMed1986

Morphological studies of the spinal cord in tetraodontiformes fishes.

The spinal cord of two tetraodontiform fishes, the Japanese file fish (Navodon modestus) and the panther puffer (Takifugu pardalis), are unusual among vertebrates in having a markedly abbreviated spinal cord with a long and flattened filum terminale. Only the rostral short part of the cord of both species is cylindrical; the greater part of the cord is markedly flat. The majority of the spinal nerve roots leave the short cylindrical part. The flattened part of the cord contains the central canal, myelinated nerve fibers, and a few motoneurons surrounding the cauda equina, and it is histologically similar to the filum terminale of amphibians and mammals. The spinal cords of other teleosts, the sun-fish and angler, also are abbreviated and possess a filum terminale and cauda equina. These orders possess an enormous head and short trunk. However, the correlation between this body form and an abbreviated cord is not causal, since the tetraodontiform species described here show ordinary body proportions. The spinal cord may be abbreviated in tetraodontiform fishes in general.

Animals↗
PubMed1984

Distribution of glycogen in the floor plate of the chick spinal cord during development.

The present study was undertaken to characterize the structural changes and the glycogen distribution in the floor plate of the developing chick spinal cord. The floor plate consisted of ventricular zone by stage 19 (staged according to Hamburger and Hamilton, 1951). The marginal zone of this plate could be distinguished as a narrow border at stage 21. It increased progressively in thickness and was the same thickness as the ventricular zone at stage 26. It increased again in thickness from stage 38 onward. Glycogen appeared and subsequently disappeared in the floor plate of the chick spinal cord during development. Little, if any, glycogen appeared in the midportion of the floor plate at stage 19. The floor plate was weakly glycogen positive from the cervical through lumbosacral segments at stage 21. In the floor plate of the lumbosacral enlargement the glycogen staining was the highest and was maximal through stages 34-37. The floor plate of the cervical and thoracic segments except for the cervical enlargement continue to have low concentrations of glycogen. The glycogen staining of the floor plate began to decrease from stage 38, and at the same time neuroglial cells began to migrate into the marginal zone of the floor plate, later than in other regions of the cord. The glycogen staining in the floor plate was barely detectable at stage 40. The accumulation of the glycogen granules in the floor plate was found only in the radial glial cells.

Animals↗
PubMed1982

Development of the glycogen body through the whole length of the chick spinal cord.

The development of the glycogen body was studied throughout the entire length of the chick spinal cord. The glycogen body cells first appeared at stage 31 on each side of the ependymal septum from the 26th to 28th segments of the spinal cord. by stage 34 the paired primordia of the glycogen body extended from the 25th to 29th segments. In the middle of the structure described classically as the glycogen body (i.e., the portion restricted to the level of the spinal nerves 26-29), these primordia were fused dorsally at stage 34 and had fused completely by stage 37. The paired primordia extended from the cervical enlargement to the lumbosacral portion of the spinal cord by stage 36 and extended to the upper cervical segments by stage 38. They were totally fused throughout the entire length of the spinal cord by stage 42. The glycogen-containin cells, in the classical glycogen body level, appeared ventrolateral to the central canal at stage 35. Thereafter they increased in number and glycogen content, and extended rostrad and caudad from the classical glycogen body level. They fused to each other and then fused with the glycogen body. Therefore, the bilateral clusters of the glycogen containing cells are considered as the ventral paired primordia of the glycogen body. The development of the glycogen body is essentially the same pattern as in the classical glycogen body throughout the entire length of the spinal cord.

Animals↗