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Biomedical subjects

T Umenai

Publications and source records attributed to T Umenai.

At least 55 records · Page 3Linked to original sources
PubMed1979

Systemic candidiasis from Candida albicans colonizing the gastrointestinal tract of mice.

Reproducible induction of systemic Candida infection was achieved by treating mice in which Candida colonization had been established in the gastrointestional tract by aminobenzylpenicillin treatment. Systemic candidiasis was induced in these mice by X-ray irradiation followed by immunosuppressive doses of dexamethasone or X-ray irradiation followed by immunosuppressive doses of trypan blue. Macrophages seem to play an important role in thie systemic infection.

Animals↗
PubMed1979

Korean haemorrhagic fever in staff in an animal laboratory.

In March, 1975, and January, 1978, there were outbreaks of Korean haemorrhagic fever (K.H.F.) among staff in the animal laboratory of the clinical research building of Tohoku University hospital. 13 doctors and 1 veterinarian had K.H.F., and all except 1 had a mild but typical clinical course. K.H.F. antibody titres were significantly raised in all 14 patients. 12 other doctors working in the same room had no symptoms and no K.H.F. antibody. K.H.F. antibody was also detected in 3 animal technicians who had not been ill, but who had worked in the same room. Antibody was not detected in any of the 4 technicians who worked in different animal rooms in another building. Epidemiological studies suggest that laboratory rats were the source of the infection. High titres of K.H.F. antibody were most common in rats reared in the animal laboratory associated with the outbreak.

Adult↗
PubMed1978

Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice.

The protective effect of an interferon inducer with a low molecular weight, 9-methylstreptimidone (9-MS), against Candida albicans infection in mice was investigated. The antibiotic was effective only when given prophylactically. When administered in such a manner, the growth of C. albicans in the kidneys and brain was inhibited at the initial stage of infection. The growth of C. albicans was not inhibited by the antibiotic in vitro, and no antifungal effect was obtained in a preparation containing induced interferon. These results suggest that the antifungal action of 9-methylstreptimidone in mice might be manifested not by direct antifungal activity but rather by a host-mediated activity that excludes interferon-inducing capability.

Animals↗
PubMed1978

Septicemia caused by Klebsiella oxytoca.

Klebsiella oxytoca was isolated from the blood of a leukemic patient. The typical pathogenicity of Klebsiella oxytoca was observed in the patient. The pathogenicity of several Klebsiella oxytoca strains isolated from blood, urine and sputum of different patients was examined in mice, and it was found that Klebsiella oxytoca isolated from the blood had a higher toxicity than the others.

Adolescent↗
PubMed1978

Systemic candidiasis produced by oral Candida administration in mice.

Systemic Candida infection from the gastrointestinal tract was examined in mice. Candida albicans was undetectable in the blood, lungs, spleen, liver or kidneys of mice 24 hr after oral Candida administration even under condition of severe damage to the host defence system, but became detectable in the liver and kidneys of mice when they received combined treatment of antibiotics, x-ray irradiation and dexamethasone 3 and 5 days after oral Candida administration.

Administration, Oral↗
PubMed1977

Antibacterial activity detected in duodenal juice.

Antibacterial activity could be detected in bacterium-negative duodenal juice from 3 patients, whereas it was not detected in bacterium-positive duodenal juice from other 3 patients. The follow-up study revealed that appearance of the activity in duodenal juice was just coincident with disappearance of bacteria in duodenal juice. The activity was not influenced by pH of the duodenal juice. These results seem to suggest that some antibacterial activity, different from that of pH, in duodenal juice regulates in some way proliferation of the upper gastrointestinal flora.

Adult↗
PubMed1977

The significance of candiduria.

Candida, which is not detectable in the urine of healthy individuals, was found in 6.5% of patient's urine. Most of the patients developing candiduria had higher-titered circulating antibody to the fungus than healthy persons did. There existed a definite relationship between the serum antibody titer and the duration of candiduria. These two variables reflected the status of the patient.

Adolescent↗
PubMed1977

Evaluation of the antigen specific to the mycelial phase of Candida albicans in the serodiagnosis of candidiasis.

We demonstrated 2 different antibodies against Candida albicans in patients' sera, the detection rates were proportional to the severity of candidiasis. One antibody was directed toward antigen shared by Candida in both blastospore and mycelial phases and the other was directed against antigen found only in the mycelial phase of Candida. The presence of the latter may reflect the invasive form of candidiasis.

Antibodies, Fungal↗