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T V Demidova

Publications and source records attributed to T V Demidova.

10 recordsLinked to original sources
PubMed1992

[The functional-morphological changes in the duodenum in chronic pancreatitis].

A study of the cavitary and membrane digestion of lipids, carbohydrates, proteins and data of the histological structure of the bioptate of the duodenal mucosa in 34 patients with chronic pancreatitis revealed the morphological picture of chronic duodenitis. This resulted in a reduction of the sorption properties of the intestinal epithelium that was manifested in a reduction of the rate of membranous digestion, mainly of lipids and lactose. Lesser degrees of protein, starch and saccharose hydrolysis were observed. Biopsy specimens of the duodenal mucosa showed a reduced activity of enterokinase and alkaline phosphatase. Antacids (almagel, phosphalugel), mineral waters ("Borzhomi", "Poliana Kvasova"), regeneration stimulators (Metacyl, retalil), agents stimulating the motor function (cerukal, reglan and oth.) are recommended for the complex treatment of concomitant duodenitis.

Biopsy↗
PubMed1987

[Cascade use of plasmapheresis and plasma filtration in the treatment of rheumatoid arthritis].

The effect of incorporation of cascade plasmapheresis and plasma filtration in multimodality therapy was studied in 4 patients with rheumatoid arthritis (RA). The result was estimated as "excellent" (complete disappearance of clinical symptoms of the articular syndrome and normalization of the activity laboratory indices) in one patient; "good" (the reduction of clinicolaboratory activity) in 2 patients and "satisfactory" (the reduction of symptoms of the articular syndrome without changes of a degree of general activity of disease) in one patient. Cascade plasmapheresis and plasma filtration significantly improved clinical and many laboratory indices of RA activity and humoral immunity indices during treatment. A long period of observation is required to assess long-term results of the effect of this method. A great advantage of the method is a possibility of decreasing substitution protein solutions without negative effects with relation to the blood total protein level. The absence of a necessity of catheterization of central vessels, more complete blood separation into plasma and erythrocytes make cascade plasmapheresis and plasma filtration more preferable. Good tolerance of the procedure, fast improvement, a chance to avoid side-effects of drug therapy, a lower risk of allergic reactions to plasma substitutes as compared to those in plasmapheresis and lymphocytoplasmapheresis make the method promising for RA treatment.

Aged↗
PubMed1986

[Comparative evaluation of the effectiveness of plasmapheresis and lymphocytoplasmapheresis in the combined treatment of rheumatoid arthritis].

The authors compared 2 methods of apheresis: plasmapheresis (PA) and lymphocytoplasmapheresis (LPA) in 24 patients with rheumatoid arthritis (RA). Both methods were shown to produce a positive effect on a course of rheumatoid process decreasing clinical and laboratory parameters of its activity, improving articular function. Under LPA influence the production of autoantibodies by B-lymphocytes was significantly lowered. PA and LPA were characterized by a more rapid development of the regression of RA symptoms as compared to drug therapy and by a good tolerance of the procedures. On the basis of the results obtained a preliminary conclusion has been made of the greater efficacy of LPA as compared to that of PA. However, the assessment of long-term therapeutic results is required to consider the probable LPA influence on cellular immunity.

Aged↗
PubMedDate not supplied

[Affinity modification of Escherichia coli Dna-polymerase I by 4-(N-2-chloroethyl-N-methylamino)-benzyl-gamma-amides of dTTP and dATP].

The interaction of dTTP and dATP gamma-4-(N-2-chloroethyl-N-methylamino) benzylamidates with E. coli DNA-polymerase I were studied. dTTP and dATP gamma-4-(N-2-hydroxyethyl-N-methylamino) benzylamidates act as competitive inhibitors of DNA-polymerase I. Ki values for gamma-analogues of dTTP and dATP have been determined. Reactive dTTP and dATP derivatives are shown to be affinity reagent for this enzyme.

Adenosine Triphosphate↗