PubMed Health⌕ Search

Biomedical subjects

T V Gavrilina

Publications and source records attributed to T V Gavrilina.

7 recordsLinked to original sources
PubMed2006

[The importance of hypothermia in the preconditioning increase of ischemic tolerance to global cerebral ischemia].

Various types of preconditioning including the main hypoxia (hypoxic, circulatory, hematic/hypemic and tissue/histotoxic), agonists of adenosine A-receptors and openers of K(ATP)-channels induce a hypothermia. A-agonists act through A1-receptors, CoCl2 and NiCl2--via endogenous adenosine and activation by it A1-receptors. The developing hypothermia correlates with neuroprotective effect and is important, but not the only mechanism of tolerance increase to global ischemia. At the similar hypothermia the preconditioning effect excels more frequently an influence of external cooling.

Adenosine A1 Receptor Agonists↗
PubMed2002

Neuroprotective effect of hypoxic preconditioning: phenomenon and mechanisms.

We developed a new model of hypoxic preconditioning improving tolerance of complete global cerebral ischemia. The role of adenosine receptors in the realization of this effect and in the mechanisms of hypoxic tolerance is demonstrated. Preconditioning decreases of body temperature, which correlates with the neuroprotective effect, but this effect does not directly result from hypothermia.

Animals↗
PubMed1991

[A differentiated approach to the therapy of the Parsonage-Turner syndrome].

The authors have analyzed the anamnestic, clinical and laboratory data in 44 patients with Parsonage-Turner syndrome. Two forms of the disease were distinguished: radicular ischemia of vascular genesis, and the local form of infectious allergic polyradiculoneuritis associated with injury to the shoulder girdle of infectious genesis.

Adolescent↗
PubMed1985

[Role of various endocrine glands in the pathogenesis of the neurologic symptoms of lumbar osteochondrosis].

Parathyroid hormone, thyrocalciotonin, testosterone, estradiol, aldosterone and renin activity of the blood plasma were radioimmunoassayed in 142 patients with neurological manifestations of lumbar osteochondritis. The blood levels of parathyroid hormone and, to a lesser degree, those of thyrocalciotonin were elevated. The levels depended on the severity and duration of the pain syndrome while thyrocalciotonin excretion depended on the degree of the degenerative dystrophic process in the spinal column. Prolonged pain syndrome was associated with an inhibited function of the gonads and the mineralocorticoid layer of the adrenals. A hypothesis is advanced, which explains the participation of the endocrine glands in the etiopathogenesis of lumbar osteochondritis and its neurological manifestations.

Adult↗
PubMedDate not supplied

[Biochemical and pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice].

Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+(ATP)-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.

Adenosine A1 Receptor Agonists↗