Biomedical subjects
Publications and source records attributed to T V Masiuk.
The problem of the regulation of the different physiological functions by enkephalines is discussed. A cite as an example the data about the regulatory action of the enkephalines on the secretory function of the stomach, pancreas and liver are discussed. The mechanisms of the enkephalines action on the secretory processes are discussed too.
A decrease in the bile flow and bile acids, proteins and lipids secretion in enkephalines infusion into the portal vein was revealed. The bile secretion changes under the effect of enkephaline seem to result from the latter effect upon metabolic processes in hepatocytes.
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The bile's proteins were found to be one of the factors regulating the intensity of bile production. Hypocholeresis induced by cycloheximide was followed by suppression of the biosynthesis and secretion of the bile's proteins.
Leu- and Met-enkephalins have been studied for their effects on bile secretion in rats. It has been found that enkephalins decrease the bile flow rate and the bile acid secretion. Possible mechanisms of the bile secretion regulation by enkephalins are discussed.