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T V Platonova

Publications and source records attributed to T V Platonova.

6 recordsLinked to original sources
PubMed1991

[Clinical aspects of diphtheria in infants].

The symptomatology of different forms of diphtheria was analyzed in 49 patients under 3 year of age. It has been established that in infants, diphtheria is marked by the diversity of localizations and a fairly high portion of associated toxic diphtheria of the stomatopharynx and disseminated croup. These gravest forms are fairly difficult to recognize them clinically. Their early diagnosis should rest on the presence of the pronounced signs of intoxication, edema of the lonsils and stomatopharyngeal mucosa, and pannicular patches spreading beyond the tonsils. In the presence of toxic diphtheria, the stages of croup become shorter while the recognition of its symptoms is embarrassing.

Child, Preschool↗
PubMed1989

[Use of adsorbed diphtheria-tetanus (DT) toxoid containing different doses of antigens in booster immunizations of children].

To decrease the antigenic load in booster immunizations of children against diphtheria and tetanus, the immunological effectiveness and reactogenicity of different doses of both antigens (i. e 1 Lf and 1 BU; 2.5 Lf and 2.5 BU; 5 Lf and 5 BU) were studied. The study revealed that all these doses of the preparation were practically nonreactogenic: the total of systemic reactions was 0.9%. The study of the immunological effectiveness of adsorbed DT toxoid with reduced antigen content revealed the advantage of the commercial dose of the preparation (5 Lf of diphtheria antigen and 5 BU of tetanus antigen) over such doses of diphtheria and tetanus antigens as, respectively, 1 Lf and 1 BU; 2.5 Lf and 2.5 BU. Still, this advantage disappeared as early as 6 months after booster immunization. The results of these investigations indicate that booster immunization of children aged 6 years and over may be made with lower doses of adsorbed DT toxoid with reduced antigen content.

Antigens, Bacterial↗
PubMedDate not supplied

[Genetic structure of Corynebacterium diphtheriae strains isolated in Russia during epidemics of various intensity].

The genetic structure of C. dipthteriae toxigenic strains isolated in Russia during the period of more than 50 years was analysed. The use of the method of ribotyping made it possible to register 17 C. diphtheriae ribotypes. The study revealed that the genetic structure of C. diphtheriae population varied in the dynamics of the epidemic process: each epidemic cycle characterized by predominant spread of epidemic strains of definite biovars and ribotypes. Thus, C. diphtheriae strains of biovar gravis, ribotype M11, dominated in the 40-60 years and C. diphtheriae strains of biovar mitis, closely related ribotypes M1 and M1v, dominated in the 80 years. During the last epidemic rise of diphtheriae morbidity in the 90 s C. diphtheriae strains of biovar gravis, closely related ribotypes G1 and G4, dominated among circulating strains. The proportion of these ribotypes began to increase 3 years before the rise of morbidity. The data of microbiological monitoring are recommended for use in the prognostication of the development of the epidemic process of diphtheria infection.

Corynebacterium diphtheriae↗