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Biomedical subjects

T V Savvina

Publications and source records attributed to T V Savvina.

At least 19 recordsLinked to original sources
PubMed1994

[Morphologic and functional aspects in the treatment of patients with intestinal fistulas].

Combination of severe purulent processes (peritonitis, phlegmons, and extensive wounds of the abdominal wall), eventration, and complete high unformed intestinal fistulas leads to rapid hemostasis disorders and emaciation. In nonoperative treatment lethality reaches 70%. Complete bilateral disconnection of the fistula bearing intestinal loop is the operation of choice in such situations. In this case the length of the disconnected intestinal segments may be two thirds of the length of the jejunum and the greater part of the colon. The results of morphofunctional study of an intestinal segment disconnected for a long period are analysed. The tactics of active surgical treatment is illustrated by clinical cases.

Adult↗
PubMed1994

[Cystic tumors of the pancreas].

Thirty-three patients were operated on for cystic tumors of the pancreas at the Vishnevsky Institute of Surgery in 1980-90. Cystadenoma of the pancreas was found in 16 (48.5%) of them and cystadenocarcinoma in 15 (45.5%). Fifteen (45.5%) patients had been previously operated on in different institutions presumably for a "cyst" of the pancreas, 6 of them repeatedly; the tumor recurred rapidly in all of them. In the Institute 30 patients underwent radical operations: 30 distal resection of the pancreas and 5 pancreatoduodenal resection. Diagnostic and palliative manipulations were performed on 3 patients. Postoperative lethality was 9.1% (3 patients). Postoperative follow-up periods lasted from 12 months to 9 years. Dissemination of the tumor occurred in 2 patients two years after the operation. The remaining 25 patients are alive and capable of working.

Adult↗
PubMed1993

Potent debriding ability of collagenolytic protease isolated from the hepatopancreas of the king crab Paralithodes camtschatica.

The debriding activity of the protease complex produced from the hepatopancreas of the king crab Paralithodes camtschatica was evaluated in vivo. The results clearly showed that the crab preparation had a high debriding ability. Individual proteases were isolated chromatographically from the crab complex to compare their debriding activities. All the purified proteases were active in vivo. The most active component of the complex was the isozyme C of crab collagenolytic protease, a member of the chymotrypsin-like protease class.

Animals↗
PubMed1993

[Problems in the surgical treatment of pancreatic chronic diseases].

The work analyses the results of 999 operations on the pancreas conducted in 861 patients with chronic oncological and nonneoplastic diseases of the gland. Pancreatoduodenal resection (PDR) was performed in 171 patients (for tumors of the pancreaticoduodenal zone in 151 and for chronic pancreatitis of the head of the gland in 20) in 13 of them a modified operation with preservation of the stomach and pylorus was carried out. The late-term results were satisfactory in both groups of patients, the survival of oncological patients was much higher after radical operations then after palliative surgery. Total duodenopancreatectomy has no advantages over PDR and should be undertaken only when there are strict indications. In chronic pancreatitis, complicated also, preference was given to organ-preserving interventions, primarily to draining operations, which preserve more fully pancreatic exocrine and endocrine functions: longitudinal pancreatojejunostomy was conducted in 106 patients, internal drainage of pancreatic cysts in 184, and occlusion of external pancreatic cysts in 70 patients. It is advisable that the most complicated, particularly repeated and reconstructive, operations on the pancreas are carried out at specialized centers in which the problem of surgical diseases of the pancreas is studied more closely.

Chronic Disease↗
PubMed1993

[Morphologic rationale for selecting composition and structure of biologically active material based on sodium alginate for wound treatment].

Morphological evaluation of composition and structure of a biologically active compound (BAC) based on sodium alginate, comprising 1% sizomycin and 0.25% protease C, on wound healing in infected rats wounds was made in experiment. The results have clearly shown that for the infected wound treatment during the first period of wound healing BAC of polyfunctional action must be applied. Biologically active substances (sizomycin and protease C) promote removal of inflammatory etiopathogenic factors, i. e. necrotic tissues and microbic bodies, while polysaccharide basis of the composition promotes stimulation of reparative processes in the wounds. Powder with granules size 315 m including 24% potassium gluconate is believed most suitable BAC structure.

Alginates↗
PubMed1992

[A morphological evaluation of the action of collagenase from the king crab Paralithodes camtschatica on the experimental wound process].

The paper presents the results of experimental morphological evaluation of the effect of a new proteolytic enzyme collagenase of crab Paralithodes camtschatica on wound healing in infected and aseptic rabbit wounds. The enzyme was applied on wounds using gauze and gelevin. The findings show that this protease is highly effective for debridement of infected wounds, the effect increasing at gelevin addition. To reach maximal therapeutical effect and diminish the inhibition effect of collagenase on granulation tissue, it is recommended to reduce the dose of protease during debridement process. Clinical application of crab collagenase must be individual as well as duration of wound enzymotherapy.

Animals↗
PubMed1991

[A method for forming and the morphological characteristics of artificial liver cysts].

Application of ultrasound surgical aspirator promotes rapid formation of major cavities with dry inner surface in the depth of hepatic parenchyma. Filling of the latter with sutured copolymer of monovinyl ether of ethyleneglycol in the ratio of one filler volume to three cavity volumes results in the formation of cysts with the given stable dimensions. Good aspiration of necrotic tissues promotes rapid formation of thin-walled cysts. The given hepatic cyst model may be used in the development of new surgical and puncture methods of treatment, as well as testing of new drugs.

Animals↗
PubMed1991

[The dynamics of the morphological changes in the liver after resections using the Soviet ultrasonic surgical aspirator].

The possibility of hepar resection by means of Soviet-made ultrasound device URSK-7N-18 was investigated in experiment on 13 mongrel dogs. The device was adapted to this surgery and was supplied with a special working part with a vacuum pump and channel for inspiration of liquid. The working part frequency is 26.5-30.0 kHz, resonance frequency is 26.5 kHz. The device does not damage blood vessels, nerves, and ducts but on the basis of morphology it provides both hemostasis at the early period after surgery owing to changes in microcirculation, and rapid wound healing by means of aspiration of necrotized tissues.

Animals↗
PubMed1990

[A method of pancreato-duodenal resection and total duodeno- pancreatectomy].

During 1975-88 the staff of the Vishnevskiĭ+ Institute of Surgery performed 95 pancreatoduodenal resections (PDR) and 23 total duodenopancreatectomies (TDPE) in malignant tumors of the head of the pancreas (49), major duodenal papilla (30), terminal choledochus (12), duodenum (12), and in 15 patients with chronic pancreatitis. In 13 cases PDR and TDPE were undertaken as a second operation after creation of biliodigestive anastomoses: after laparoscopic cholecystostomy in 24 and after various abdominal operations in 20 cases. In 30 cases PDR was carried out with the formation of a pancreaticojejunal+ anastomosis, by the longitudinal techniques in 7 of them, in 47 cases with occlusion of the pancreatic duct, and in 6 with the formation of a "occlusive" pancreaticojejunal anastomosis++ suggested by the authors. PDR was performed in 3 cases with maintenance of the stomach and in 4 in combination with vagotomy. The mortality rate was 20% after PDR and 39.1% after TDPE.

Choledochostomy↗
PubMed1990

[Morphological assessment of Co2-laser fusion using a flexible light guide in lymphovenous and venovenous anastomoses in experimental animals].

In experiments on 13 mongrel dogs with CO2 laser supplied with flexible fiber guide there were formed 17 lympho-venous and 4 veno-venous anastomosis. There were no inadequate sealing, narrowing or aneurysm of the anastomosis. Histopathologic investigations after 3, 6-8, 13-16 days and 1 year showed that vascular walls were positioned correctly. Endothelial surface has continuous character both along the vessel as anastomosis line.

Anastomosis, Surgical↗
PubMed1986

[Characteristics of the implantation of venous patches into the common bile duct of dogs].

Seven free grafts of an anterior wall of common bile duct with autovenous patches were realized using microsurgical technique in 7 dogs. Carcass and cavity drainage were not used. It was shown that one month after the operation the interior surface of the patch was covered with normal duct mucosa and the duct was not dilated. No inflammatory and macrophage reactions were observed in the patch or surrounding tissue.

Animals↗