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Biomedical subjects

T V Serebrovskaia

Publications and source records attributed to T V Serebrovskaia.

At least 19 recordsLinked to original sources
PubMed1998

[A method for intermittent hypoxic exposures in the combined treatment of bronchial asthma patients].

The method of intermittent increasing normobaric isocapnic hypoxia was used for the treatment of bronchial asthma. The parameters of respiration, metabolism, free-radical processes and immune system were monitored before and after training. The therapeutic diagnostic complex "Hypotron" (Ukraine), which allowed to determine the individual reactivity of the patient's respiratory system, tolerance to hypoxia, and to choose an optimal program of treatment, was used. The hypoxic training resulted in considerable increase of lung vital capacity, maximal ventilation and forced expired velocity. Normalization of initially increased free radical processes, accompanied by a decrease in the lipid peroxidation products was observed. The hypoxic training positively influenced specific and nonspecific immunological status, and appeared to be associated with a far better stimulation of lymphocytes and neutrophils.

Adult↗
PubMedDate not supplied

[Neutral peptide hydrolase activity in human blood in hypoxia].

Athletes were taken to an altitude of 2100 m and allowed to get adapted to the highland environment for a month. Then blood serum neutral peptide-hydrolases were measured at rest and after exercise. Also, metabolic and respiratory parameters were investigated. In response to identical workloads some subjects showed a decrease (Group 1) while others showed an increase (Group 2) of proteolytic activity. Group 1 subjects exhibited high reactivity of the respiratory system whereas Group 2 subjects showed enhanced anaerobic glycolysis.

Altitude Sickness↗
PubMedDate not supplied

[The relation of the reactivity of the human respiratory system, mental and physical work capacity and metabolic characteristics during a 1-year stay in the mountains].

People with the highest rates of mental working capacity staying for a year at an altitude of 1680 m below sea level are characterized by less pronounced responses of respiration to moderate hypoxia and great ventilatory response to maximally endured hypoxic action, by higher glucose content in blood and physical working capacity. Many relationships typical of the middle mountains are inverse ones under conditions of a one-year stay at an altitude of 3650 m below sea level. In the case of a total decrease in indices of mental and physical working capacity people with the highest rate of information processing are characterized by less reactivity of the respiratory system, greater resistance to ultimate hypoxia, lower glucose concentration, less physical working capacity.

Adaptation, Physiological↗
PubMedDate not supplied

[Human higher nervous activity during adaptation to moderate altitude].

26 practically healthy youths of 16-18 years old not adapted to the mountains earlier were investigated under the conditions of a plain (Kiev) and at the height of 2100 m and 3000 m above sea-level (Chegem). A stay under the conditions of moderate altitude for one month was found to favour amelioration of the characteristics of the functional lability (CFL) of the nervous system, information processing velocity, attention concentration and distribution, short-term memory volume, general subjective feeling as well as shortening the latent periods of visually-motor reactions. Large adaptive shifts of the CFL and more stable positive effect of mountain adaptation after returning to the plain were found in persons with initially high functional lability level in comparison to those with mean or lower values of CFL. Positive connection between the CFL and the degree of adaptive changes of external respiration was observed under the conditions of moderate altitude. Statistically significant connection of the CFL with the respiratory center sensitivity to hypercapnia was found rather than their correlation with the value of ventilatory response to acute hypoxia during gas mixtures respiration.

Adaptation, Physiological↗
PubMedDate not supplied

[Various individual features of human adaptation to altitude].

Two groups of young healthy men--natives of lowlands who for one year lived and worked in chronic hypoxia (Group 1 at an altitude of 1680 m with PO2 = 120 mm Hg and Group 2 at an altitude of 3650 with PO2 = 90 mm Hg) were examined. It was found that after this prolonged exposure the subjects showed a higher sensitivity of the respiration system to hypoxia, an enhanced lung ventilation and circulation, a lower gas exchange and physical work capacity. The concentration of lactic acid at rest in the Group 2 subjects was 47% higher than in the Group 1 subjects. The lactate/pyruvate ratio in the Group 2 subjects increased by 46% thus indicating an enhanced rate of anaerobic processes. A higher deficiency of buffer bases, a lower concentration of bicarbonates in blood at rest and during exercise tests of the Group 2 subjects pointed to metabolic acidosis. The subjects with a higher rate of anaerobic metabolism in a low PO2 environment displayed a diminished sensitivity of the hypoxic stimulation of respiration, an increased tolerance to the very low PAO2 and a reduced work capacity in chronic hypoxia.

Acclimatization↗