Biomedical subjects

T V Vikhrova

Publications and source records attributed to T V Vikhrova.

3 recordsLinked to original sources

PubMed2003

[Causes of biliary sludge].

AIM: To specify characteristics of biochemical bile composition contributing to destabilization of colloid properties of bile in patients with biliary "sludge". MATERIAL AND METHODS: 37 patients with "sludge" in the gallbladder (GB), 10 patients with cholelithiasis and 10 patients with intact GB participating in the study were examined for bile portion B bile acids (BA), cholesterol and phospholipids (PL); lipid and lipoprotein blood composition. RESULTS: Three types of biochemical composition of bile in GB "sludge" patients were identified. 22 patients had elevated levels of cholesterol and PL in subnormal content of BA (group 1); 9 patients had normal FA and cholesterol, low content of biliary PL (group 2); 6 patients had normal concentrations of the three components (group 3). Blood lipids were characterized by elevated levels of total cholesterol and LDLP cholesterol in group 1; low HDLP cholesterol and triglycerides in group 2 and almost normal values in group 3. Basing on these data, causes of "sludge" formation in the GB are suggested. CONCLUSION: Biliary "sludge" may form because of excessive cholesterol in bile, low phospholipid levels or in normal proportion of the studied substances.

Adult↗

PubMed2003

[The problem of biliary sludge].

The authors review current literature on etiology, pathogenesis and classification of biliary sludge (BS); they analyse factors promoting formation of BS and show that ultrasonic investigation is the key diagnostic method, detecting various forms of BS and differentiating BS with parietal new-growths of the gallbladder, evaluating function of the latter and controlling efficacy of conservative therapy. Follow-up results demonstrate that BS can disappear spontaneously, be persistent in a part of patients, form stones in 20% patients. Clinical picture in BS has no specific symptoms but in 33-75% cases it is associated with development of biliary pancreatitis as a results of secondary dysfunction of the Oddi's sphincter. The latest findings on efficacy of litholytic therapy in BS and data on possible use of nonsteroid anti-inflammatory drugs as inhibitors of mucin production to prevent recurrent cholelithiasis are presented.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMed2001

[Local and common humoral immunity in cholelithiasis and biliary sludge].

Analysis of local and systemic humoral immunity in 75 patients with cholelithiasis (36 patients) and biliary "sludge" (39 patients) are presented in this article. The bile of these patients were examined. The sIgA reduce in the bile, that testifies to the suppression of local humoral immunity but IgG and IgM increase due to inflammatory changes of gallbladder were revealed. Increase of all immunoglobulins, especially IgA, was revealed in blood serum. The both groups of the patients had demonstrated the same changes but with different expressiveness. This fact testifies to the similarity of pathological processes in these patients.

Adolescent↗