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T Várkonyi

Publications and source records attributed to T Várkonyi.

At least 19 recordsLinked to original sources
PubMed2001

Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood.

Colorectal carcinoma rarely affects children and has a dismal prognosis with 5-year survival rates as low as 2.5%-7% despite apparently radical surgery. Here we report the case of an adenocarcinoma of the sigmoid colon in a 15-year-old girl preceded by uncertain abdominal complaints of 5 years' duration. Pathological work-up revealed a tumour with lymph node metastases (pT3NI). Immunohistochemical evidence of p53 overexpression by the tumour cells raised the suspicion of an underlying Li-Fraumeni syndrome. In addition, there were aphthoid ulceration, fissuration of the non-tumorous mucosa, along with a mixed transmural infiltrate composed of macrophages, eosinophils, and non-typical giant cells, which were compatible with simultaneous Crohn's disease. Anamnestic data concerning the occurrence of idiopathic inflammatory bowel disease or colorectal carcinoma in the patient's relatives were non-contributory. The present results suggest a possible relationship between Crohn's disease and colon cancer due to the defective p53 gene product.

Adenocarcinoma↗
PubMed1997

[Gallbladder hypomotility in diabetic polyneuropathy].

A study was made of the pathogenic role of gallbladder hypomotility, which is presumably responsible for the high incidence of gallstone disease in long-standing diabetes mellitus. The gallbladder motility of diabetic patients (n = 10) was measured by means of quantitative hepatobiliary scintigraphy, and the severity of concomitant autonomic and sensory polyneuropathy was determined. The presence of marked gallbladder hypomotility was proven, and a positive correlation was observed between the severity of autonomic neuropathy and the contractile disorder. In this group of diabetic patients, a hypaesthetic sensory polyneuropathy too was recognized, the degree of which exhibited a positive correlation with the autonomic neuropathy score. This study underlines the important role of the autonomic neural dysfunction in the development of gallbladder hypomotility accompanying long-term diabetes mellitus.

Diabetes Mellitus, Type 1↗
PubMed1997

[Erythrocyte-induced "torsade de pointes" ventricular tachycardia].

A case of erythromycin-induced acquired long QT syndrome and "torsades de pointes" ventricular tachycardia is reported. The peculiar ventricular tachyarrhythmia was evoked by orally administered erythromycin (1.5 g/die) in the presence of diuretic (clopamide)-induced hypokalaemia. The pause-dependent "torsades de pointes" was preceded by prolonged QTU interval (560 ms), "particular bigeminy" and "short-long-short" RR interval sequence. The recurrent ventricular tachycardia causing syncopal attacks was abolished by the discontinuation of erythromycin treatment, K+/Mg(2+)-supplementation and oral mexiletine therapy. It is emphasized that the macrolide antibiotic/prokinetic erythromycin, applied in therapeutic dosages, blocks the rapidly activating delayed rectifier potassium current (IKr), and as such, prolongs ventricular repolarization and may be "torsadogenic".

Clopamide↗
PubMed1997

[Increase of the QT interval dispersion in diabetes mellitus].

The QT dispersion, measured as the interlead variability of QT interval (QTd = QTmax-QTmin), reflects the spatial inhomogeneity of ventricular repolarization times. The authors studied QTd and heart rate-corrected QTd (QTc-d) in 81 patients with diabetes mellitus (IDDM: 39, NIDDM: 42) using Bazett's formula; 20 non-diabetic subjects acted as controls (means +/- SD). QTd (43 +/- 17 ms) and QT c-d (52 +/- 20 ms) were increased (p < 0.05) as compared to the control values (QTd = 32 +/- 17 and, QTc-d = 35 +/- 17 ms, respectively). A significant difference was also observed in QTc-d if the two diabetic groups were compared to the control separately (p < 0.05). Moreover, comparison of the diabetic groups (IDDM vs NIDDM) revealed that type I diabetes mellitus is accompanied by a more pronounced spatial dispersion of ventricular reporlarization (QTd = 49 +/- 16, and QTc-d = 59 +/- 19 ms) as compared to NIDDM (QTd = 38 +/- 16, QTc-d = 46 +/- 20 ms [p < 0.01]). The hypothesis that increased QTd/QTc-d is truly a predictive marker of sudden arrhythmic cardiac death in patients with diabetes mellitus needs further clinical investigation.

Adult↗
PubMed1996

Elevated levels of plasma vasoactive intestinal peptide in human acute myocardial infarction.

The plasma levels of vasoactive intestinal peptide in peripheral vein were measured in human acute myocardial infarction. The plasma vasoactive intestinal peptide level was increased within 1 h after the onset of the symptoms of acute myocardial infarction (Group 1, n = 9), compared with normal values (6.3 +/- 0.7 vs. 2.8 +/- 0.9 pg/ml, P < 0.05). Two or more hours after the onset of acute myocardial infarction there was no subsequent increase in peripheral plasma vasoactive intestinal peptide levels (n = 26). Ten days after the onset of acute myocardial infarction, the elevated plasma vasoactive intestinal peptide levels in Group 1 had normalized (3.5 +/- 0.5 pg/ml).

Aged↗
PubMed1996

[Amiodarone-induced pulmonary fibrosis].

The most feared side-effect of long-term amiodarone therapy is progressive alveolitis/pneumonitis leading to pulmonary fibrosis. The case history of a patient is presented who received amiodarone unnecessarily in a high dose (600 mg/day) for 4 years: drug-induced dermatopathy, hypothyroidism and lung fibrosis developed. After cessation of amiodarone treatment the pulmonary complication did not disappear therefore glucocorticoid therapy was introduced. New-onset improductive cough, dyspnea, fever and/or enhanced erythrocyte sedimentation rate may suggest the presence of amiodarone pulmonary toxicity and may form the basis of indication of high-resolution computed tomography (HRCT). Amiodarone-induced pulmonary involvement can be shown by HRCT early, before the appearance of any considerable abnormality of chest radiography.

Amiodarone↗
PubMed1993

The pharmacological reactivity of an isolated circular smooth muscle strip of the rabbit common bile duct.

An in vitro isolated spiral strip of rabbit common bile duct was prepared and tested for its pharmacological reactivity. It was found to be a suitable preparation with a long lasting and stable sensitivity when exposed to various drugs. The pharmacological reactivity proved to vary along the common bile duct; the different portions (sphincteric, median and hepatic) displayed different activities to the various agonists and antagonists. The following receptors were identified in different sections: alpha and beta-adrenergic, muscarinic cholinergic, bradykinin, H1 and prostaglandin F2 alpha. Only the sphinteric portion exhibited rhythmic peristalsis; the other portions produced merely small, irregular spontaneous contractions.

Adrenergic alpha-Agonists↗
PubMed1993

[Collagenous sprue--a rare form of celiac disease in adulthood].

The authors report a case of collagenous sprue. This condition is characterized by coeliac type small bowel malabsorption, resistant to gluten free diet and other therapeutic efforts, associated with poor prognosis. The diagnosis depends on the histological demonstration of extensive collagenization of the lamina propria in the flat jejunal mucosa. This disease must be kept in mind at differential diagnosis of chronic diarrhea with progressive malabsorption, especially if it is resistant to gluten withdrawal in contrast to conventional coeliac disease.

Biopsy↗
PubMed1992

[Collagen sprue--a rare form of adult celiac disease].

The authors report the first case of collagenous sprue in Hungary. This condition is characterized by coeliac type small bowel malabsorption, resistant to gluten free diet and other therapeutic efforts, associated with poor prognosis. The diagnosis depends on the histological demonstration of extensive collagenization of the lamina propria in the flat jejunal mucosa. This disease must be kept in mind at differential diagnosis of chronic diarrhoea with progressive malabsorption, especially if it is resistant to gluten withdrawal than conventional coeliac disease.

Age Factors↗
PubMed1990

[Immunohistochemical studies in contaminated small bowel syndrome].

This study was undertaken to evaluate the number of the immunoglobulin producing cells in the lamina propria of the small intestine by immunocytochemical techniques, using peroxidase-antiperoxidase (PAP) complex in normacid patients with CSBS. 25 patients were studied including 13 patients with bacterial overgrowth, where the bacterial concentration was higher than 10(4) colony forming units/ml, and 12 subjects with normal bacterial concentration, served as control. The patients with CSBS were treated with antibiotics according to the antibiotic resistance. After treatment the luminal bacterial concentrations was lower than 10(4) cfu/ml in 7 of 13 patients (CSBS I. group). In 6 patients the bacterial concentration remained high (CSBS II. group). The immunoglobulin producing cells were determined in biopsy specimens taken from the lower part of duodenum. The number of the IgA and IgM producing immunocytes was significantly decreased only in the CSBS II. group. Our results show that temporary immunological alterations may play an important role in the mechanism of the recurrent CSBS.

Anti-Bacterial Agents↗
PubMed1989

Effect of insulin on the glycogen content of the rat small intestinal mucosa.

The authors examined the quantitative changes in the glycogen content in rat's small intestinal mucosa under the effect of insulin. They found that glycogen content increases significantly during the first 60 minutes, then it decreases gradually, and regains the control value only after 6 hours. It appears that as regards its metabolic activity, the small intestinal mucosa is not an insulin resistant organ.

Animals↗
PubMed1987

Dermatitis herpetiformis: relation between circulating immune complexes, small-intestinal mucosal status, and immunohistopathological findings.

Some aspects of humoral immunity and the status of the jejunal mucosa were investigated in 22 patients with classical dermatitis herpetiformis (DH). The mucosal status was characterized on the basis of immuno- and histopathological findings and functional analysis of malabsorption and disaccharidase activity. There was no significant abnormality in the serum immunoglobulins, whereas the IgA and C3 contents of the circulating immune complexes (established by polyethylene glycol precipitation and inverse radial immunodiffusion techniques) were significantly elevated. Polyorgan-specific autoantibodies of IgG type were present in the sera of 95% of the 22 patients. Functional analysis of the gastrointestinal tract revealed some abnormality in all of the 18 cases examined, while direct immunofluorescence studies demonstrated an increased number of subepithelial IgA lymphoid cells in all of the 15 cases examined. These findings did not correlate well with the jejunal mucosal morphology. This study supports the view that IgA deposited in the skin is formed in the gut.

Adult↗
PubMed1986

Gastric acidity: an important factor regulating the composition of the bacterial flora in the small intestine.

The role of gastric acidity in regulating the bacterium composition in the small intestine was studied. Gastric acidity was determined with the Kay test. Intestinal juice obtained by a probe was examined for the presence and number of microorganisms. Parallel with the increase in gastric acidity, the number of bacteria in the jejunal juice generally decreased. Their composition also varied: in anacid patients E. coli predominated whereas in those with free hydrochloric acid, Streptococcus alpha haemolyticus and anaerobic Peptostreptococcus formed the bulk of the microflora. These data underline the importance of the role of acidity in the development of bacterial contamination in the jejunum.

Bacteria↗