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Biomedical subjects

T W Bunch

Publications and source records attributed to T W Bunch.

33 records · Page 2Linked to original sources
PubMed1980

Azathioprine with prednisone for polymyositis. A controlled, clinical trial.

A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis. Sixteen patients received 60 mg prednisone per day plus either azathioprine (2 mg/kg of body weight per day) or placebo for a period of 3 months. Creatine phosphokinase (CPK) levels fell to normal slightly sooner in the placebo group, but not significantly so. The azathioprine group did not become significantly stronger (P = 0.58) and did not manifest significantly greater improvement of histopathologic features of muscle (P = 0.80) than the placebo group. Initial CPK elevations were significantly related to the degree of muscle inflammation (P = 0.037), but this was not the case at 3 months (P greater than 0.05). Normalization of the CPK could not be equated with disease control. Type II fiber atrophy, attributed to steroid therapy, was more marked in women than in men (P less than 0.03).

Adult↗
PubMed1980

Disease-modifying drugs for progressive rheumatoid arthritis.

In patients with rheumatoid arthritis who do not respond to therapy with salicylates or nonsteroidal anti-inflammatory agents, stronger and potentially more toxic drugs are then considered. At the present time in the United States, this generally means a trial of hydroxychloroquine, gold, penicillamine, azathioprine, or cyclophosphamide. Each of these drugs is discussed with regard to pharmacology and possible modes of action, pertinent clinical studies, and toxicity.

Arthritis, Rheumatoid↗
PubMed1980

Blood test abnormalities in runners.

Physicians are conditioned to interpret blood test results outside "normal" limits as being signs of disease. In endurance-trained athletes, such "abnormal" tests results may instead be indications of physical activity. Data from six runners are presented illustrating that anemia, liver disease, myocardial ischemia, or renal disease might erroneously be diagnosed unless the physician is aware of the exercise habits of the patient.

Aspartate Aminotransferases↗
PubMed1979

Cardiac involvement in polymyositis: a clinicopathologic study of 20 autopsied patients.

Cardiac involvement in polymyositis was investigated in 20 autopsied cases. Clinically, 13 of 18 patients had abnormal electrocardiograms, and 9 of the 20 patients had previous evidence of congestive heart failure. Histologically documented myocarditis was detected in 6 patients (4 with congestive heart failure and 2 without), 4 of whom also had small vessel disease of the myocardium. Patients with polymyositis may have a cardiopathy in the absence of overt myocardial inflammatory disease.

Adolescent↗
PubMed1977

Survival in polymyositis: corticosteroids and risk factors.

Thirty-one polymyositis patients treated with low-dose corticosteroid were age and sex matched with 31 polymyositis patients treated with high-dose corticosteroid. Although disease severity at onset of the study was similar in the groups, no statistically significant difference in survival was found. The death rate in each group was greater than normal. The presence of dysphagia or severe muscle weakness lessened the chances of survival. Controlled trials with other drugs should be carried out.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Deforming arthritis of the hands in polymyositis.

Arthritis of the hands with erosions, periosteal calcification, and interphalangeal thumb joint instability was seen in 6 patients with polymyositis. "Overlap" features such as Raynaud's phenomenon, positive LE clot test, and positive antinuclear antibody test were present, but clinically the primary disease was clearly polymyositis. This rather unusual constellation of roentgenographic findings strongly suggests the possibility of polymyositis.

Adult↗