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T W CHANG

Publications and source records attributed to T W CHANG.

At least 19 recordsLinked to original sources
PubMed1964

INHIBITION OF SYNTHESIS OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS BY CEPHALOTHIN.

Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.

Anti-Bacterial Agents↗
PubMed1964

MORPHOLOGICAL CHANGES IN GRAM-NEGATIVE BACILLI EXPOSED TO CEPHALOTHIN.

Chang, Te-Wen (Tufts University School of Medicine, Boston, Mass.), and Louis Weinstein. Morphological changes in gram-negative bacilli exposed to cephalothin. J. Bacteriol. 88:1790-1797. 1964.-Exposure of gram-negative bacteria to cephalothin (7-[thiophene-2-acetamido]-cephalosporanic acid) revealed the formation of long filaments and large bodies, which were capable of reverting to normal cells when removed from contact with the drug. The degree of morphological change was found to be related to the concentration of antibiotic in which the organisms were suspended. The large bodies were altered by contact with solutions of varying osmolarity. Different species showed variation in the ability to develop large bodies. A relationship between antibiotic sensitivity and the capacity to resist morphological alteration was observed. Though most sensitive gram-negative bacilli were strikingly changed by exposure to cephalothin, naturally resistant ones were unaffected. Organisms made drug-resistant in vitro underwent changes in cellular form which were qualitatively the same but less intense than those which developed in parent strains originally sensitive to cephalothin.

Anti-Bacterial Agents↗
PubMed1963

IN VITRO BIOLOGICAL ACTIVITY OF CEPHALOTHIN.

Chang, Te-Wen (Tufts University School of Medicine, Boston, Mass.) and Louis Weinstein. In vitro biological activity of cephalothin. J. Bacteriol. 85:1022-1027. 1963.-Cephalothin is a "broad-spectrum" antibiotic active, in low concentrations, against Diplococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus. Shigella, Salmonella, and Proteus mirabilis were the most sensitive of the gram-negative organisms. Escherichia coli and Aerobacter aerogenes were suppressed to a lesser degree, whereas Pseudomonas aeruginosa and Herellea were highly resistant. Penicillin-sensitive and -resistant strains of S. aureus were equally susceptible to cephalothin. Exposure to increasing concentrations of the drug very frequently led to the development of resistance in gram-negative organisms; this was observed less often with S. aureus. Cephalothin stimulated the production of penicillinase by staphylococci, which remained sensitive to the cephalosporanic acid derivatives despite repeated subculture in increasing concentrations of the agent. Cephalothin was not inhibited by penicillinase. This antibiotic was more toxic to cultures of human amnion and mouse embryo cells than benzyl penicillin G but was less injurious than oxytetracycline, chlortetracycline, and demethylchlortetracycline; tetracylcine produced about the same degree of cellular damage as cephalothin.

Acinetobacter↗