Biomedical subjects
Publications and source records attributed to T W Cole.
Imidazole pyruvate was found to be a very potent natural chelating agent in reversing the inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+. This metabolite may play a physiological role in gluconeogenesis.
A novel procedure for the purification of methylmalonyl-CA mutase from Propionibacterium shermanii has been described which employs affinity chromatography on a column of immobilized vitamin B-12 linked covalently to Sepharose. The method has the advantage of being simple and rapid, thus enabling the purification of the enzyme to near homogeneity with good yields.
This article describes another regular phenomenon in the sub-pulse behaviour of pulsars. The drift speed of successive sub-pulses follows a sawtooth pattern with a linearly increasing drift speed and sudden jumps as the speed drops to repeat the cycle.
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