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T W Nielsen

Publications and source records attributed to T W Nielsen.

8 recordsLinked to original sources
PubMed1976

Chain elongation and desaturation of palmitic acid in liver microsomes of rats subjected to hyperbaric exposure.

The enzyme activities associated with chain elongation and desaturation of fatty acid in hepatic microsomes from rats held at 1 ATA of air, 1 ATA of He-O2, and 20 ATA of He-O2 were studied. It was found that both the microsomal chain elongation and desaturation of fatty acids were depressed in rats held at 1 ATA of He-O2 as compared to animals held at 1 ATA of air. When animals were exposed to an environment of 20 ATA of He-O2, the chain elongation of fatty acid was about the same as for rats held at 1 ATA of air and was two times greater than for the rats held at 1 ATA of He-O2. The desaturase activity was depressed as compared to the two groups of control animals held at 1 ATA of air and 1 ATA of He-O2.

Air Pressure↗
PubMed1975

The effect of hyperbaric exposure of 20 atmospheres-absolute (He-O2) on sphingoglycolipids of rat tissues.

The effect of hyperbaric exposure of helium-oxygen at 20 atmospheres-absolute (ATA) on sphingoglycolipids of rat liver, kidney, lung and spleen was studied. No changes were found in the total lipids of the tissues of rats held in ambient air, helium-oxygen mixtures at 1 ATA and 20 ATA. The amounts of three glycolipids in the spleen and the monoglycosyl ceramide in the lung were decreased in the stressed animals. There were changes in the fatty acid profiles of glycolipids between groups of animals held in ambient air and He-O2 at 1 ATA. Greater changes were observed in the amount of glycolipids from liver and kidney of animals held at 1 ATA and 20 ATA, providing additional evidence that helium can affect cellular metablism at ambient pressure. Chain elongation of fatty acids was observed in glycolipids of liver, kidney and spleen of rats exposed to helium-oxygen at 20 ATA compared to animals held in helium-oxygen at 1 ATA.

Animals↗