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Biomedical subjects

T W Robinson

Publications and source records attributed to T W Robinson.

At least 19 recordsLinked to original sources

Pregnancy in renal transplant recipients: case report.

Pregnancy in a renal homograft recipient resulted in an emergency cesarean section at 32 weeks' gestation secondary to maternal small bowel obstruction with necrotic bowel and subsequent intestinal perforation. The 1814 gm female product of this pregnancy had a moderate degree of in utero asphyxia, which subsequently, based on radiologic studies, had to be differentiated from the possibility of a congenital viral infection. Several concerns arose regarding the effects on the fetus by maternal immunosuppressive therapy, the risk factors faced by both the fetus and the mother secondary to the mother's renal disease, and the general outcome of the increasing number of pregnancies in this population.

Adult

Familial tufted angioma.

Tufted angioma is a rare slowly progressive vascular lesion found typically in children and young adults. Cases appear sporadically and clinically have been confused with low grade angiosarcoma, Kaposi's sarcoma, and multiple glomus tumours. We report a case of a patient with tufted angioma in whom a strong family history of similar lesions is apparent, transmitted in an autosomal-dominant mode of inheritance.

Adult

Toxic pustuloderma: a self-limiting eruption.

Three patients are described who developed numerous pinhead sized pustules within areas of a widespread toxic erythema. The eruption was precipitated by food poisoning in one patient, a suspected, but blood-culture-negative septicaemia in another and in the third patient, by a cephalosporin. This self-limiting syndrome consists of fever, a pustular and erythematous eruption, a neutrophil leucocytosis, subcorneal and spongiform pustules but without a history of psoriasis. We believe that this entity of toxic pustuloderma represents a severe form of toxic erythema.

Adult

Anesthetic management of neonatal cardiac transplantation.

Anesthetic management of thirteen neonatal heart transplant patients is reviewed. Donor management, preoperative, operative and early postoperative management is discussed. Ten of 13 patients in this series survived the operation and appear to be developing normally.

Anesthesia, General

Erythema multiforme due to griseofulvin.

Three patients are reported who developed erythema multiforme during treatment with griseofulvin. To our knowledge there have been no previously documented reports of this drug causing erythema multiforme in either the English or American literature.

Adult

Polyostotic fibrous dysplasia associated with extensive linear epidermal naevi.

Albright's syndrome is characterized by the combination of polyostotic fibrous dysplasia, precocious puberty and café-au-lait spots. We describe a patient with polyostotic fibrous dysplasia who also had extensive linear epidermal naevi, an association that has not been previously described in the English literature.

Adult

Giant-cell tumour of the tendon sheath--an uncommon tumour presenting to dermatologists.

We describe a patient who presented with two skin-coloured, non-mobile, soft dermal nodules on the tip of the distal phalanx of the left middle finger. Skin biopsy revealed the features of a giant-cell tumour of the tendon sheath. This benign tumour is one of the most common tumours affecting the hand but is, we believe, infrequently encountered by dermatologists and rarely mentioned in the dermatological literature.

Adult

Betamethasone valerate ointment compared with fluocinonide FAPG.

Betamethasone 0.1% as valerate in an ointment base and fluocinonide 0.05% in a fatty alcohol propylene glycol (FAPG) base have been compared in a double-blind trial of 76 patients with either eczema or psoriasis. The results show betamethasone valerate ointment to be significantly (P less than.05) superior to fluocinonide FAPG in the treatment of both these skin conditions. In the light of publications from other studies on betamethasone valerate cream this trial indicates that the ointment base considerably increases the efficacy of betamethasone valerate.

Betamethasone

Exacerbation and reactivation of Herpesvirus hominis infection in mice by cyclophosphamide.

Cyclophosphamide has been shown to potentiate the growth of Herpesvirus hominis in the skin of Webster Schneider mice. Higher skin yields of virus were obtained, marked dissemination of virus to the brain was produced and mortality in mice was increased. Serum neutralizing antibody titres were suppressed. The system may serve as a good model for the study of specific antiherpes drugs.

Animals