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Biomedical subjects

T Wajima

Publications and source records attributed to T Wajima.

At least 19 recordsLinked to original sources
PubMed2000

Sudden cardiac death from thrombotic thrombocytopenic purpura.

Clinical thrombotic thrombocytopenic purpura (TTP) is characterized by a pentad of microangiopathic hemolytic anemia, thrombocytopenia, neurological symptoms, renal involvement, and fever. A case of TTP in which early symptoms and signs were suggestive of ischemic heart disease, renal failure, and severe thrombocytopenia developed to a rapid outcome of death. The postmortem examination revealed coronary artery microthrombi, typical of TTP. The clinical presentation of this TTP was atypical: severe thrombocytopenia, striking renal and CNS symptoms were present, but fever and anemia were not present. Thrombotic thrombocytopenic purpura is an uncommon condition that carries a high fatality rate if untreated. Awareness of this syndrome and its high risk of sudden death underlines the importance of rapid diagnosis and treatment.

Coronary Thrombosis↗
PubMed1991

Fibrinolytic profiles in patients with small cell carcinoma of the lung.

1. Elevated levels of fibrinogen were observed in 100% of untreated patients with SCCL. The elevated fibrinogen tended to normalize with complete remission in response to combination chemotherapy. 2. FDPs were increased in 33% of patients in the limited disease group and in 37% in the extensive disease group. Elevated levels of D-dimers were seen in 26% in the limited disease group and in 50% in the extensive disease group. Levels of FDPs did not parallel levels of D-dimers. Some cases of very advanced disease showed increases in both FDPs and D-dimers. 3. When FDPs were within normal limits, D-dimers tended to be elevated. 4. Levels of plasminogen, alpha 2-antiplasmin, and plasmin were and remained within normal limits throughout the course of treatment, while concentrations of FDPs and D-dimers increased. 5. Plasminogen, alpha 2-antiplasmin, plasmin, FDPs and D-dimers did not show any trend. 6. Peripheral blood measurements did not reflect the crucial role of plasmin in modulating blood fibrinolysis and the metastatic cascade. 7. Evidence of the action of the fibrinolytic system at tumor sites failed to correlate with results of laboratory tests.

Carcinoma, Small Cell↗
PubMed1990

[Statistical analysis of nuclear medicine in the Higashi Nippon Gakuen University Dental Hospital].

The number of radionuclide in vivo tests carried out at the Higashi Nippon Gakuen University Dental Hospital was statistically analyzed and discussed. The subjects were all patients admitted to the Division of Nuclear Medicine during the seven years between 1981 and 1989. The total number of the patients included those introduced through medical facilities in Toubetsu-cho and others. The results of this analysis were as follows: 1) The proportion of the first time patients admitted to the Higashi Nippon Gakuen University Dental Hospital was only 11 percent of all patients. 2) Cases of radionuclide in vivo tests at the Higashi Nippon Gakuen University Dental Hospital decreased in number, annually. However the proportion of tumor scintigraphy and bone scintigraphy increased gradually.

Female↗
PubMed1989

Factor VIII inhibitor in insulin-dependent diabetes mellitus.

Acquired factor VIII inhibitor was found in a 69-year-old white male with insulin-dependent diabetes mellitus. He presented with left lower abdominal pain and hematoma after a fall. Preoperative hemostasis studies were normal except for prolonged aPTT. Prolonged aPTT was not corrected by 1:1 mixture with normal fresh plasma and incubation showed further prolongation with time. Factor VIII:c was 3.5%. The inhibitor titer was 7.5 Bethesda units. The possible mechanism causing antibody to factor VIII was postulated to be an autoimmune process and/or increased immunogenicity owing to glycosylation of factor VIII coagulant protein.

Aged↗
PubMed1981

Thrombophlebitis in cancer patients.

Five cancer patients (three with lesions in the lung and one each with breast and head and neck cancer) with multiple metastases developed "migratory thrombophlebitis." These patients were not ambulatory. None of the patients showed a picture of "consumptive coagulopathy," although a "hypercoagulable state" was observed. Fibrinogen levels were normal or increased, FDP were slightly increased, and AT-III was decreased. Prior to heparin therapy, values for PT and PTT were within normal range. Sodium heparin, 30,000 to 36,000 units per day, was administered by continuous intravenous infusion. Despite prolongation of the PTT to twice the baseline levels, signs and symptoms of thrombophlebitis persisted for several days. When thrombophlebitis was controlled with heparin, Coumadin therapy was instituted, but thrombophlebitis recurred at the original site and at new sites, even though the prothrombin time was in the therapeutic range (2 to 2 1/2 times the normal value). The antithrombotic action of heparin depends on a normal quantity of plasma AT-III. Long-term use of heparin is feasible, but the optimal time for discontinuation of heparin treatment has not been established. Heparin is superior to oral anticoagulation therapy to control thrombophlebitis associated with advanced cancer.

Adult↗
PubMed1975

Nitroblue tetrazolium test in patients with sickle-cell anemia.

Forty-four patients who had sickle-cell anemia were examined to evaluate the reliability and usefulness of the nitroblue tetrazolium (NBT) test. The patients with sickle-cell anemia in painful crisis with bacterial infection often had low percentages of NBT reduction or negative results. The NBT test did not differentiate well between sickle-cell anemia with bacterial infection and without bacterial infection.

Adult↗