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Biomedical subjects

T Webb

Publications and source records attributed to T Webb.

At least 127 records · Page 7Linked to original sources
PubMed1976

Studies on the relationship between concanavalin A and SV40-transformed human fibroblasts.

The extent of binding of 125I-Con A to the surface of SV40-transformed human fibroblasts and the degree of agglutination of the cells by the native lectin have been measured. In addition, trypsinized and succinylated Con A have been used to study the effects of the lectin upon certain cell growth parameters. Trypsinized Con A was found to alter the growth rate, the saturation density and the contact inhibition of the transformed cells, an effect not neutralized by alph-methyl-D-mannoside.

Agglutination↗
PubMed1976

The transformation by simian virus 40 of cells from patients with mucopolysaccharidosis and from normal controls.

Fibroblasts derived from individuals with mucopolysaccharidosis, an inborn error of metabolism, have been found to be more easily transformed by simian virus 40 than are cells derived from normal individuals. The increased susceptibility does not seem to depend upon changes in glycoprotein at the cell surface. Repeated observations were necessary to demonstrate these differences, and we do not believe that this test is suitable for routine screening for cancer susceptibility.

Adsorption↗
PubMedDate not supplied

The fragile (X) syndrome: the mutation problem.

In an attempt to understand the nature of the mutational event leading to the fra(X) syndrome, we have searched for sporadic cases in 3 populations: affected males, affected females, and non-affected transmitting females. In all 3 populations there was a dearth of isolated cases, and the reasons for this are discussed.

Female↗
PubMedDate not supplied

Fragile Xq27 in somatic cells derived from different tissues.

Prenatal diagnosis for the Martin-Bell syndrome resulted in the detection of 4 fragile X-positive male fetuses and 2 female fetuses. Studies carried out on monolayer cultures derived from various tissues from these show that fra-Xq27 can be ascertained in cells from testis, lung, kidney, skin, ovary, and muscle. This suggests that the fragility of the X chromosome may be present in all somatic cells. There appears to be no strong correlation between the level of marker detected and the involvement of the tissue from which the cells were derived in the manifestation of the syndrome. The level of fra-X is dependent rather more on culture conditions than on cell type except for lymphocytes, in which detection is easier.

Cells, Cultured↗