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Biomedical subjects

T Weiner

Publications and source records attributed to T Weiner.

10 recordsLinked to original sources
PubMed1994

Molecular mechanisms involved in tumorigenesis and their surgical implications.

Our understanding of normal and malignant cell growth has rapidly advanced in the last two decades as new technologies have accelerated the ability to resolve the underlying molecular mechanisms. The speed and complexity of this advance, as well as the inadequate and confused nomenclature of molecular oncology, has made this field difficult to follow. Nevertheless, many future therapies will be targeted to a genomic level and clinicians will be called upon to communicate with basic scientists in implementing them. To facilitate the surgeon's part in this dialogue, we present a broad review of the molecular genetics of cancer. The selected bibliography contains many review articles by leading researchers in this field. Particular emphasis has been placed on the themes that are emerging, such as oncogenic mechanisms, tumor suppressor genes, signal transduction, the multistage concept of carcinogenesis, and molecular diagnostics and therapies.

Animals↗
PubMed1994

Chronic lung disease is the leading risk factor correlating with the failure (wrap disruption) of antireflux procedures in children.

Recurrent gastroesophageal reflux (GER) after antireflux procedures (ARP) has been correlated with significant neurological impairment (NI). Other major risk factors for recurrent GER have not been extensively characterized. The authors reviewed their experience with ARPs in children to better characterize the risk factors for recurrent GER and identify successful management strategies for these patients. The charts of 281 consecutively treated children who had an ARP at our institution (1985 to 1992) were reviewed. The neurological status of each child was assessed as normal or impaired (cerebral palsy, seizures, mental retardation, spasticity), and other medical diagnoses such as chronic pulmonary disorders (eg, interstitial disease, cystic fibrosis, bronchopulmonary dysplasia, asthma, etc), and congenital malformations and syndromes were identified. The average follow-up period was 3 years (range, 1 to 7.5 years). Patients with symptoms of recurrent GER were evaluated with an upper gastrointestinal study. Patients with a radiologically intact fundoplication and suspected GER were further evaluated with a 24-hour pH probe. Statistical analyses were performed using the Fisher's Exact Test. Of the 281 patients who underwent ARP, 39 had documented recurrent GER (average, 16 months after surgery). Twenty-five (64%) of these children had chronic pulmonary disease (CPD). Thirty-two percent of all children with CPD had recurrent GER after ARP, versus 7% of those without CPD (P < .0001). For children with NI and CPD there was an increased risk (P < .0001) of failure when compared with the risk in the normal subgroup (children without CPD or NI) who underwent ARP.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

Growing alternatives for computerized pharmacy.

HPI has chosen a unique approach in its computer project development and implementation. It has prioritized financial and distributive pharmacy services incorporated into a mainframe system. This system is intended as a national framework with high flexibility for addition of new services. It is referred to as Patient Records Electronically Prepared (PREP).

California↗
PubMed1981

Black attrition in physician assistant training programs.

We report on correlates of attrition for Blacks and Whites in physician's assistant training programs. The data reveal an unusually high rate of attrition for Blacks (65 per cent) and, in particular, for Black males (59 per cent). This latter group, regardless of educational background and other potential predicators of educational success, encounters significant difficulty in the educational process. An understanding of this attrition phenomenon is useful for designing admissions policies which identify a larger percentage of low risk recruits to health professions education.

Adult↗
PubMed1978

Very low birthweight infants: a follow-up study.

This study was undertaken to determine the outcome of infants delivered at the Royal Hospital for Women during the years 1971 to 1975 who weighed 1500 g or less at birth and who survived the first 28 days of life. Of the 104 neonatal survivors, 79 were seen by one of the writers, nine were seen by other medical practitioners, four had died after the neonatal period, the parents of two children could not be induced to bring their child to be examined, and the remaining ten could not be traced. Abnormalities were found in 15 of the 88 children examined. Three had major physical handicaps (problems causing a restriction of normal lifestyle), 11 had minor handicaps (problems which did not restrict normal lifestyle), and eight had evidence of developmental delay. Infants who were small for gestational age tended to be below the 10th percentile for height or weight at follow-up more often than infants of the appropriate weight for gestational age.

Australia↗