PubMed Health⌕ Search

Biomedical subjects

T Welsh

Publications and source records attributed to T Welsh.

9 recordsLinked to original sources
PubMed2001

Social capital.

Explore the source record for details and available documents.

Community Health Services↗
PubMed2000

A case study of benefits & potential savings in rural home telemedicine.

This case study reports results from a federally funded home telemedicine program in rural Grainger County, Tennessee. Patients, family caregivers, and providers were generally satisfied with this low-cost, user-friendly telemedicine program that used the plain-old-telephone system. Mileage and nurse drive time were reduced and nursing productivity was improved during this demonstration project.

Community Health Nursing↗
PubMed1997

Cloning and characterization of the gene for amylosucrase from Neisseria polysaccharea: production of a linear alpha-1,4-glucan.

The gene for the amylosucrase from Neisseria polysaccharea (ATCC 43768) was cloned by use of a functional expression system in Escherichia coli XL1-Blue. The deduced amino acid sequence of the protein has homology to the sequences of the alpha-amylase class of enzymes, with the highest similarities being found to the sequences of the trehalose synthase from Pimelobacter sp. strain R48 (17) and amylomaltase from Thermotoga maritima (11). However, the regions of highest homology within the alpha-amylase class of enzymes, which are essential for the catalytic activity, are only scarcely found in the sequence of amylosucrase. By using the enzyme isolated from culture supernatants of transformed E. coli cells, it is possible to synthesize linear alpha-1,4-glucans from sucrose, indicating that the enzyme is not capable of producing alpha-1,6-glycosidic linkages on its own.

Amino Acid Sequence↗
PubMed1997

Continuous passive motion with accelerated flexion after total knee arthroplasty.

The use of continuous passive motion after total knee arthroplasty remains controversial. A new approach, starting continuous passive motion at 70 degrees to 100 degrees flexion in the recovery room (Group I) was evaluated. A randomized, prospective study of 210 consecutive total knee arthroplasties was performed at two institutions. The control population (Group II) started continuous passive motion at 0 degree to 30 degrees, and progressed toward 100 degrees flexion. Flexion at postoperative Day 3 (Group I = 82.5 degrees, Group II = 72.8 degrees), and at discharge (Group I = 89.1 degrees, Group II = 84.3 degrees) were significantly different. There was no significant difference between the groups at 4 weeks (Group I = 5.0 degrees-104.1 degrees, Group II = 5.6 degrees-102.0 degrees), 6 weeks (Group I = 2.3 degrees-104.8 degrees, Group II = 2.7 degrees-103.6 degrees), 12 weeks (Group I = 1.7 degrees-107.7 degrees, Group II = 4.7 degrees-108.2 degrees), or at 1 year (Group I = 0.5 degree-113.2 degrees, Group II = 1.8 degrees-110.5 degrees). In Group I, wound necrosis developed in one patient that required a gastrocnemius flap. This major complication was caused by a tight dressing, and not necessarily to the accelerated flexion continuous passive motion. This investigation shows that continuous passive motion using accelerated flexion allows increased flexion during the hospital stay without increased risk of complications, pain, or blood loss. This has significant implications for achieving safe, early discharge. However, no difference was found at followup of 4 weeks or greater, and this did not add significantly to the final outcome.

Aged↗
PubMed1994

Incarceration of the jejunum in the epiploic foramen of a four month old foal.

A 4-month Arabian filly presented for abdominal pain of 30 hours duration was found to have tachycardia, tachypnea, congested mucous membranes and gross abdominal distension. Further examination disclosed gastric reflux and small intestinal distension. Dehydration, prerenal azotemia, electrolyte abnormalities and metabolic alkalemia were observed. There was a progressive nonresponse to analgesic medication and deterioration in the foal's physiologic condition consistent with a small intestinal strangulating obstruction. Surgical exploration was declined. Necropsy examination revealed incarceration of the mid-jejunum in the epiploic foramen with proximal jejunal distension. This case is remarkable as the first report of entrapment of the jejunum in the epiploic foramen of a young foal.

Abdominal Pain↗
PubMed1992

Palliative treatment of hyperinsulinism with cyproheptadine and diazoxide.

Treatment for hyperinsulinism in infants and children can be difficult and has included numerous treatment modalities. This paper reports 16 months of palliative treatment with cyproheptadine and diazoxide in a child with hyperinsulinism initially diagnosed at 6 months of age (her insulin level was 80 microU/mL while her glucose level was 38 mg/dL). She continued to have episodes of staring and alteration in level of consciousness while receiving her usual doses of diazoxide (12 mg/kg) alone. Mean nocturnal glucose values, which were quite low during treatment with diazoxide alone, improved significantly with the addition of cyproheptadine to her therapeutic regimen. Fasted C-peptide values, elevated during diazoxide alone, returned to the normal range with combination treatment for 16 months. Cyproheptadine and diazoxide in combination may be useful for treatment of hyperinsulinism that presents after the neonatal period.

Blood Glucose↗
PubMed1990

Diagnostic value of vertical nystagmus recorded from ENG.

A patient with a cerebellar hemorrhage was evaluated using electronystagmography (ENG). Data obtained on the horizontal channel were only mildly abnormal. However, vertical nystagmus was clearly evident when the patient was tested in a darkened room with eyes open. This additional procedure may have saved the patient severe complications. With eyes open in darkness vertical nystagmus is more easily differentiated from eye blinks and clinicians are encouraged to look for this valuable central vestibular system sign.

Adult↗