Introducing "ERIC", a living research ethics database.
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Databases, Factual↗
Biomedical subjects
T Wiseman
Publications and source records attributed to T Wiseman.
A concept analysis of empathy.
The concept of empathy lies amid much confusion. This analysis addresses that confusion using Walker and Avant's model of concept analysis, and looks at what empathy is: is it trait or state, is it dynamic or static, and how is it recognized and measured? Implications of these findings are discussed, limitations of the study are acknowledged and areas for further work suggested.
Adult↗
Working with NGOs: PAHO's approach.
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Acquired Immunodeficiency Syndrome↗
Rapid measurement of binding constants and heats of binding using a new titration calorimeter.
A new titration calorimeter is described and results are presented for the binding of cytidine 2'-monophosphate (2'CMP) to the active site of ribonuclease A. The instrument characteristics include very high sensitivity, rapid calorimetric response, and fast thermal equilibration. Convenient software is available for instrument operation, data collection, data reduction, and deconvolution to obtain least-squares estimates of binding parameters n, delta H degree, delta S degree, and the binding constant K. Sample through-put for the instrument is high, and under favorable conditions binding constants as large as 10(8) M-1 can be measured. The bovine ribonuclease A (RNase)/2'CMP system was studied over a 50-fold range of RNase concentration and at two different temperatures. The binding constants were in the 10(5) to 10(6) M-1 range, depending on conditions, and heats of binding ca. -15,000 cal/mol. Repeat determinations suggested errors of only a few percent in n, delta H degree, and K values over the most favorable concentration range.
Binding Sites↗