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Biomedical subjects

T Wojno

Publications and source records attributed to T Wojno.

15 recordsLinked to original sources

Bilateral periocular actinic granuloma in a patient with renal failure: a clinicopathologic study.

PURPOSE: We report a 50-year-old man with end-stage renal disease who has developed bilateral inner and outer canthal nodules. METHODS: The nodules were excised, fixed in 10% formalin and 2.5% glutaraldehyde, and processed for light and electron microscopy, respectively. RESULTS: Histological examination showed elastotic changes with associated granulomatous inflammation. The granulomatous reaction was centered around elastotic fibers, and some giant cells engulfed the fibers. Areas of dystrophic calcification were identified. A diagnosis of actinic granuloma was made. The differential diagnosis and histopathology of actinic granuloma, i.e. granuloma annulare, rheumatoid nodule, and necrobiotic xanthogranuloma, are discussed. CONCLUSION: This case of an actinic granuloma originating in the sun-damaged periocular skin provides further evidence that elastotic degeneration may be associated with a giant cell reaction. It is, however, unclear which antigens are responsible for initiating the granulomatous response and whether elastotic material on its own can elicit a granulomatous reaction.

Calcinosis↗

Removal of an infected silicone rod frontalis sling without recurrence of ptosis.

We examined a child with congenital ptosis. She underwent a bilateral silicone rod frontalis sling operation. One of the slings became infected and necessitated removal. We noticed no recurrence of her ptosis after sling removal. Removal of a frontalis sling does not invariably lead to recurrence of ptosis. We hypothesize that a scar tract formed in the plane of tissue from which the sling was removed. This band of scar tissue can act as a frontalis sling to elevate the eyelid.

Blepharoptosis↗

Evaluation of biomatrix hydroxyapatite ocular implants with technetium-99m-MDP.

Hydroxyapatite ocular implants appear to offer excellent cosmetic reconstruction with lower rates of infection and extrusion compared to other integrated implants. However, vascularization of the implant needs to be established before the artificial eye is attached to the implant. Technetium-99m-methylene diphosphonate (MDP) scintigraphy can be utilized as a noninvasive method for determining the vascularity of the hydroxyapatite ocular implants. A case is presented in which 99mTc-MDP uptake in the implant was deemed sufficient for further surgical intervention.

Durapatite↗

Dermis grafts in socket reconstruction.

The feasibility of using dermis in socket reconstruction is explored in the rabbit. The results indicate that dermis may be a suitable source of graft material where mucous membrane replacement is needed. Histological sections of the grafts are provided and are contrasted with scleral grafts, a substance whose behavior is socket surgery has been studied previously. A clinical case is presented also of a patient with a severely contracted anophthalmic socket who was reconstructed successfully with a dermis graft.

Adult↗

Orbicularis muscle pathology after botulinum toxin injection.

A 49-year-old woman underwent 1 year (six injections) of botulinum toxin treatments for essential blepharospasm. When she became dissatisfied with the need for repeat injections, she elected to undergo an orbicularis muscle stripping procedure for control of spasms. Pathologic examination of the orbicularis muscles showed only minimal degenerative changes. Botulinum toxin injection into the orbicularis is known to provide only temporary relief of essential blepharospasm. This may be because the resulting orbicularis atrophy is insufficient to maintain permanent control of these spasms.

Atrophy↗

Bilateral optic nerve sheath enlargement.

A 43-year-old man presented with progressive visual loss in each eye associated with bilateral optic nerve sheath enlargement. At surgery, the left optic nerve sheath was diffusely distended with clear fluid, but biopsy of the optic nerve and its sheath revealed only normal structures. Decompression of the right optic nerve prevented further deterioration of vision in this eye. The etiology of this condition and pathogenesis of visual loss is unknown.

Adult↗

Pathology of an orbital dermis-fat graft.

A patient had an orbital dermis-fat graft implanted for a secondary socket reconstruction. The graft shrank only minimally and a portion had to be excised to permit better prosthesis fitting. The pathologic findings are presented. Although a generalization cannot be made on the basis of one case, prudence should be exercised with regard to the degree that such grafts are oversized in socket reconstruction.

Adipose Tissue↗

Granuloma annulare of the eyelid.

A five-year-old patient presented with nodular lesions on the left upper lid, index finger and thigh. Biopsy revealed granuloma annulare. The lesions resolved without treatment. This entity should be considered in the differential diagnosis of eyelid nodules.

Biopsy↗

Lower eyelid ectropion following chemical face peeling.

A 72-year-old female developed a cicatricial ectropion after a chemical face peel, a previously undocumented complication. Surgical correction was successful. The pathological specimen is presented and therapeutic implications are discussed.

Aged↗

Orbital leiomyosarcoma.

A 36-year-old man had a six-month history of painless swelling in the medial orbit. Surgical exploration of this mass revealed a leiomyosarcoma. The tumor was entirely removed, as was all local surrounding tissue.

Adult↗

Actinic comedonal plaque of the eyelid.

A variety of actinic lesions occur on the eyelids and facial skin. Actinic comedonal plaque is an unusual entity that falls into this category. We successfully treated such a lesion with cryotherapy.

Actins↗

Peripapillary subretinal neovascularization causing pseudoedema of the optic disc.

A patient with typical lesions of senile macular degeneration exhibited an apparent swollen disc in one eye. A leaking peripapillary subretinal neovascular membrane was found to be the cause of the disc edema. The experience with this case indicates that such a membrane should be considered in the differential diagnosis of the swollen disc, especially when macular degeneration is present.

Aged↗

Ultraviolet light, cataracts, and spectacle wear.

Two groups of patients older than 60 years were examined for degree of development of nuclear sclerotic cataracts. The first group of patients had worn glass spectacles for a majority of their lives, while the patients in the second group had never worn spectacles or had worn only reading glasses. Subjects in the group with spectacles showed significantly less development of sclerotic nuclear lens changes. These findings may be due to the screening effect by spectacle glass of light in the ultraviolet range and suggest that uv light may be one of the risk factors in the development of nuclear sclerotic cataracts.

Adolescent↗

Unusual findings in serpiginous choroiditis.

Retinal pigment epithelial detachment and optic disk neovascularization developed in two men, 51 and 49 years old, who had serpiginous choroiditis. Fluorescein angiograms demonstrated loss of pigment epithelium and choriocapillaris in the late stages in both cases. Both men sustained permanent visual loss. In one case the final visual acuity of the affected eye was 20/200. In the second case the final visual acuity was R.E.: counting fingers at 4 feet and L.E.: 20/70.

Choroiditis↗