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Biomedical subjects

T Wuppermann

Publications and source records attributed to T Wuppermann.

At least 37 records · Page 2Linked to original sources

[Oxygen pressure fields in ulcers of the lower leg].

Using a multi-wire surface electrode, oxygen pressure fields were determined in leg ulcers of 11 patients with chronic venous insufficiency (cvi). In three of them, cvi was combined with arterial occlusive disease. The histograms of all patients with very low PO2 values revealed microcirculatory disturbances of the ulcer tissue. The influence of leg position is reflected in the histograms. Patients with cvi showed higher PO2 values when the leg was raised in comparison with when it was in the hanging position. The patients with mixed ulcerations showed a significant increase in tissue PO2 when the leg was in the hanging position, which shows the importance of arterial perfusion pressure. After a compression bandage had been applied to the legs with cvi, the tissue oxygen pressure of the ulcers increased markedly, probably as a result of diminished blood stasis. These results can be explained either by a rarefaction of capillaries in the ulcer tissue or by fibrin diffusion barriers around the capillaries. The changes in the histograms after bandaging are thought to be caused by an improvement in venous circulation.

Adult↗

[Semi-quantitative functional phlebography (author's transl)].

The ascending phlebography of the lower extremity gives no functional evaluation of venous blood-flow under the activity of the venous muscular pump. A newly developed semiquantitative method of functional phlebography by videodensitometry extends the measurability of vein dynamic. The influence of compression hoses on venous flow dynamics associated with varicose veins is examined by this method.

Absorptiometry, Photon↗

[Autologous 131J-tagged human fibrinogen for early detection of venous thrombosis (preparation, biological and in vivo properties) (author's transl)].

A method for preparation of autologous 131J-tagged human fibrinogen is demonstrated. In vitro the preparation is characterized by content of fibrinogen, protein, plasminogen, clottability and molecular weight. Total plasma radioactivity, specific radioactivity, non-protein-bound radioactivity, biologic half-life and the local activity at the thrombus define the properties in vivo. With the above criteria autologous 131-J-tagged human fibrinogen was shown to be useful for early diagnosis of venous thrombosis.

Blood Coagulation Tests↗

[Quantitative analysis of fibrinmonomer in Arwin-therapy (author's transl)].

The quantitative measurement of plasma fibrin monomeres in three patients with Arwin-treatment by affinity chromatography on agarose fixed fibrinogen and the "tüpfel method" demonstrated high specifity and sensitivity. Plasmafibrinmonomer concentration clearly differs both before and during treatment from results reported in the literature. The method results in a better control of dangerous situation, especially with additional application of fibrinolytic agents.

Ancrod↗

[Morphometry of primary varicose veins (author's transl)].

Morphometric investigations into the perforating veins in cases of primary varicosities have revealed typical, so far unrecognized, features of insufficiency. A significant difference was found in the diameters of central and peripheral parts of the vein amounting to a ratio of 1.5:1 with single, and 1.8:1 with paired incompetent perforators. These perforators therefore act in producing a jet. The pathophysiological and diagnostic significance of this jet phenomenon is discussed. Variations in the pattern and frequency of incompetent perforators were found between the medial and lateral aspects of the calf. Evidence concerning the mode of incompetent perforators is discussed.

Humans↗