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Biomedical subjects

T Y Woo

Publications and source records attributed to T Y Woo.

At least 19 recordsLinked to original sources
PubMed1989

Cutaneous changes of dermatomyositis precede muscle weakness.

A retrospective review of 50 patients with dermatomyositis was performed to determine the temporal relationship between onset of muscle weakness and skin involvement. We found that cutaneous changes sometimes preceded muscle weakness more than a year before the onset of muscle weakness. These findings suggest that the characteristic dermatomyositis eruption without muscle weakness should not preclude a diagnosis of dermatomyositis, and these cases should be carefully followed.

Dermatomyositis↗
PubMed1989

Malignant dermal cylindroma in a patient with multiple dermal cylindromas, trichoepitheliomas, and bilateral dermal analogue tumors of the parotid gland.

A malignant dermal cylindroma of the scalp arose from one of multiple long-standing dermal cylindromas in a 76-year-old man with coexisting trichoepitheliomas and bilateral dermal analogue tumors of the parotid gland. The histologic transition from a benign dermal cylindroma to an anaplastic keratinocytic neoplasm was readily apparent. The malignant dermal cylindroma is a rare neoplasm. To our knowledge, the constellation of benign and malignant dermal cylindromas, multiple trichoepitheliomas, and salivary gland neoplasms has not been previously reported.

Adenoma↗
PubMed1986

Continual skin peeling syndrome. An electron microscopic study.

We encountered a patient with continual skin peeling syndrome, a rare disorder in which generalized, noninflammatory exfoliation of the stratum corneum occurs. Although scaling occurred spontaneously in our patient, he was also able to manually peel sheets of skin without bleeding or pain. Histologically, there was separation of corneocytes above the granular cell layer. Ultrastructural examination revealed an unusual type of intracellular cleavage, in which the plasma membrane of the "peeling" cell remained firmly adherent to the underlying cell while the upper part of the cell exfoliated. Unique intercellular electron-dense globular deposits were localized to the stratum corneum.

Biopsy↗
PubMed1986

Topical application of isotretinoin gel improves oral lichen planus. A double-blind study.

In a double-blind study, 20 patients with oral lichen planus were treated twice daily with 0.1% isotretinoin gel or the vehicle alone for two months. Subsequently, patients who used the placebo received the active preparation for another two months. Patients treated with the active medication displayed significantly greater improvement than patients receiving the placebo. Patients who were treated initially with the placebo showed statistically significant improvement after receiving the topical isotretinoin treatment for two months. Side effects from using the gel were primarily a transient burning sensation or irritation on initial application.

Administration, Topical↗
PubMed1985

Subungual osteocartilaginous exostosis.

Subungual exostosis arises underneath the nail plate, originating from the underlying bone. The characteristic appearance of this disorder may occasionally mimic a wide variety of tumors, including subungual verrucae, endochondroma, fibroma, or amelanotic melanoma. With such a wide variety of similar-appearing tumors, optimal treatment of this disorder clearly lies in proper recognition and treatment.

Child↗
PubMed1985

Keratoderma hereditaria mutilans (Vohwinkel's syndrome): a trial of isotretinoin.

An 8-year-old girl with the classic findings of keratoderma hereditaria mutilans (Vohwinkel's syndrome) was seen. Treatment with isotretinoin was instituted to decrease the hyperkeratosis and to prevent further autoamputation. After a 12-week course at 2 mg per kg per day, the patient had only minimal decrease in the amount of hyperkeratosis. Because of the well-known long-term risks of systematic retinoids and her suboptimal improvement, therapy was discontinued.

Child↗
PubMed1985

Systemic isotretinoin treatment of oral and cutaneous lichen planus.

Lichen planus of the skin and mucous membranes may be disabling. Severe pruritus or bullous lesions may be incapacitating when they occur while erosive oral lesions may be extremely painful. Various treatment modalities have been attempted including corticosteroids (parenteral, intralesional, and topical) and photochemotherapy. Recent successful therapeutic trials of topical retinoic acid and oral etretinate have been completed. Two patients with cutaneous and severe erosive oral lichen planus unresponsive to conventional therapies responded to a trial of oral isotretinoin with prompt and successful remission of cutaneous and oral lesions. This suggests that systemic isotretinoin may have a unique position in the treatment of mucous membrane lichen planus that is refractory to conventional therapies.

Administration, Oral↗
PubMed1985

Juvenile linear scleroderma associated with serologic abnormalities.

We investigated 24 juvenile cases of linear scleroderma for the presence of systemic disease and serologic abnormalities. Thirteen of 24 patients had antinuclear antibodies (ANA) at titers of 1:40 or greater. Rheumatoid factor (titers greater than or equal to 1:20) was detected in seven of 17 patients tested, five of whom also had ANA. Two of five patients with ANA and rheumatoid factor had systemic diseases, such as nephritis and Raynaud's phenomenon. One patient with ANA developed typical dermatomyositis. Consequently, patients with linear scleroderma may be at some risk for developing systemic collagen-vascular diseases. On initial presentation, patients with linear scleroderma should give a complete history and receive a thorough physical examination as well as undergo laboratory evaluations for the presence of ANA and rheumatoid factor. Long-term observation with periodic reevaluation is appropriate for many members of this group.

Adolescent↗
PubMed1985

Association of pili torti and leukonychia.

A patient with both pili torti and leukonychia had a family history indicating dominant inheritance for the nail changes. However, no relatives had hair abnormalities. The authors briefly review both of these unusual entities.

Adolescent↗
PubMed1984

Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine.

Dermatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM.

Adenocarcinoma↗
PubMed1984

Nifedipine in scleroderma ulcerations.

Cutaneous ulcerations may be due to a variety of causes, including vasculitis, infections, arterial insufficiency, and microvascular damage. The net effect is diminished blood flow to the skin. Nifedipine, a calcium antagonist, has been shown to improve cutaneous blood flow and to alleviate reactive vasospastic ischemia (Raynaud's phenomenon). The authors report an ischemic ulcer of scleroderma showing visible improvement with nifedipine therapy.

Aged↗
PubMed1984

Apocrine cystadenoma arising in a nevus sebaceus of Jadassohn.

An increased incidence of benign and malignant adnexal tumors has been noted to occur within the nevus sebaceus of Jadassohn. We report a case of a 41-year-old white woman with a blue cyst on her scalp which had recently developed within a congenital "birthmark." Excision of the lesion revealed that the nodule was an apocrine cystadenoma within a nevus sebaceus of Jadassohn. The clinical features of nevus sebaceus with apocrine cystadenoma are discussed and the various tumors which may arise within the nevus sebaceus are reviewed.

Cystadenoma↗