Biomedical subjects
Publications and source records attributed to T Yabuki.
We describe here a 70 kDa transcription factor A1F-B, which preferentially binds to an element encompassing a CCAAT motif on the rat aldolase B promoter. Comparison of binding specificities, relative molecular masses, and subunit compositions with those of other known CCAAT-binding factors indicated that A1F-B is a novel member of CCAAT-binding factors.
We reported a case of cervical myelopathy due to hypertrophy of the posterior longitudinal ligament (HPLL). A 56-year-old man who developed spastic gait and urinary disturbance was admitted to our hospital. Neurological examination disclosed muscle weakness and hyperreflexia in all extremities, and superficial sensory disturbance below Th 4. Neither plain films nor tomograms of the neck showed ossification of the posterior longitudinal ligament (OPLL). However, myelography, myelo-CT and MR scan revealed HPLL and anterior compression of the cervical cord at C2-C6. From these findings, we diagnosed this case as cervical myelopathy due to HPLL. Clinical symptoms were relieved by posterior decompressive laminoplasty. HPLL has been preserved. During the following four years, ossification has not emerged into the hypertrophic region of posterior longitudinal ligament. This case suggests that HPLL may be a novel clinical category of compression myelopathy. Further observation will be needed.
Investigations of the effect of direct current on 1) fracture healing, and 2) ligament healing was conducted by applying 10 microA to 1) the defect of the fibula, and 2) that of the patellar ligament of adult rabbits. After time periods for stimulation all specimens were tested with combinations of roentgenological, histological, biomechanical and biochemical methods. The results were analyzed and compared with the non-stimulated, opposite side and with the normal tissue. The electricity produced 1) a more massive callus with normal histological features in an early stages at the fracture site, and 2) higher tensile stiffness and earlier change of the collagen types in the newly-formed tissue, though no significant differences were observed as to 1) the mechanical parameters of callus and bone material, and 2) histological findings of repairing tissue. Electrical stimulation was indicated not only on bone tissue but also on non-osseous tissues and their components.
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In the third through seventh cervical vertebrae, the lateral one-quarter of the body is originally part of the neural arch and is formed slightly cephalad to the rest of the vertebral body. After excavation of the superior vertebral notch, the osseous prominence that remains is the uncus. The intervertebral disc is limited to the area between the anlagen of the vertebral bodies, and the portion of the intervertebral space that is lateral to the disc is occupied by loose fibrous tissue. When this tissue is resorbed it leaves a space that constitutes Luschka's joint. These anatomical findings are based on dissections of forty-five specimens comprising human fetuses and autopsy material from individuals who ranged in age from eight days to eighty-nine years.
The investigation of the effect of direct current on the mechanical properties of experimental fractures was conducted by applying 7-10 microA of constant current to the osseous defect of the rabbits' fibulae. The fibulae were tested mechanically with the combined methods of nondestructive technique and breaking-strength measurement. The result was analyzed in relation to the volume of the newly formed callus, which was estimated by roentgenographic appearance and calculation. There is no accurate proof that an electrically stimulated callus is superior in mechanical strength. A more massive callus in a relatively earlier stage suggests that the stimulated callus may have some advantages over the nonstimulated callus.
Collagen solution extracted from the adult steer hide was mixed with the synthesized hydroxyapatite and after cross linking lyophilized. Small blocks of this sample were filled in bone defects of rabbit fibula. Two control groups were made, of which one was filled with the collagen block contained no apatite and the other group left as a sham operation. The experimental group showed more active bone formation than control groups.
Cervical spondylotic radiculopathy is likely to develop when the superior articular process is anterior to the posterior margin of the vertebral body, as determined by lateral radiographs of the spine.
The anterior and the posterior longitudinal ligaments (ALL and PLL) of the cervical spine were examined. The ALL and the deep layer of the PLL are continuous, and surround the vertebral body. The superficisl layer of the PLL surrounds the dura mater, nerve roots and the vertebral artery, suggesting that this membrane may serve as a protective membrane for the soft tissues inside the vertebral canal rather than as a conventional ligament.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.