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Biomedical subjects

T Yamagami

Publications and source records attributed to T Yamagami.

At least 199 records · Page 11Linked to original sources

Nd-YAG laser as a surgical tool.

As neurological operation has necessitated effective haemostatic devices, CO2 and Nd-YAG lasers have been introduced in this field. The CO2 laser was first studied and used in neurological surgery and many problems, such as safety, mobility, and others, were overcome by pioneers. The Nd-YAG laser has been developed mainly for endoscopic surgery. However, we noticed its strong haemostatic effect, used it in neurosurgery and found it to be quite effective in removing tumours. The following properties of the Nd-YAG laser are especially fitted for neurosurgical surgery: the laser beam is conducted through a light, thin and flexible quartz fibre; penetration of the laser beam into tissues is controlled by the output wattage, and the grade of coagulation is controlled by duration of irradiation time and by the output wattage.

Brain Neoplasms↗

Extent of thermal penetration of Nd-YAG laser--histological considerations.

The extent of thermal penetration of Nd-YAG laser was studied histologically. The material was obtained from seven cases of various types of intracranial and extracranial tumours and normal temporal muscle obtained at operation. After irradiation of the tumour surface with the laser, the tumours were removed and depth and width of pathological changes caused by heat were studied. Histologically, materials consisted of a vaporized surface, carbonized, vesicular, necrotic, oedematous layer and surrounding intact brain tumour tissue. There was a direct relationship between the thermal effect and the irradiated thermal energy (watt x exposure time x pulse number). The results showed that the thermal effect was limited to a depth of 6 to 10 mm from the irradiated surface when irradiated 4 times at the power of 90 watts for 2 seconds.

Adult↗

Acromegaly with multiple secreting pituitary adenomas.

A case of acromegaly with two separate growth hormone-secreting pituitary adenomas is presented. The multiplicity was suspected on computerized tomographic scan and confirmed at transsphenoidal surgery. Possible occurrence of multiple adenomas is discussed.

Acromegaly↗

[A case of cerebral cryptococcosis, with special reference to computerized tomography findings].

A case of cryptococcosis simulating brain tumor was reviewed. A 66-year-old female was admitted to our hospital with chief complaint of vertigo, gait disturbance and dysarthria. These symptoms started about one year before admission and worsened. Vomiting and urinary incontinence appeared. Neurological examination revealed left cerebellar ataxia and dysarthria. In plain CT (computerized tomography) irregular ill-defined low density area was noted in the cerebellar vermis and bilateral cerebellar hemispheres. And slight ventricular dilatation was found. Irregular shape of ring-like enhancement corresponding to capsule and patchy or mottled enhancement inside the tumor were seen. Suboccipital craniectomy was performed and yellowish necrotic tumor with hard capsule was removed. Histological diagnosis was not neoplasm or tuberculoma. Postoperatively liver function progressively worsened. She died due to disseminated intravascular coagulation. Autopsy revealed typical liver cirrhosis without malignant change. 3.0 X 2.5 cm sized, slightly hard, yellowish lesion was found on upper part of cerebellar hemispheres. This had extremely necrotic tissue and a great number of cryptococcus neoformans were found. And other intracranial lesion was not confirmed. Finding of pulmonary cryptococcosis was not gained. Our case is very rare because of solitary cerebellar abscess and absence of meningitic episode or pulmonary cryptococcosis. There are three types of inflammation in cerebral cryptococcosis. The commonest manifestation is the meningitic type, the second mode is granulomatous lesion and the third and the least presentation is intracranial abscess formation. CT reveals various findings according to clinical stage. CT findings are those of meningitis, meningoencephalitis, granuloma and abscess. Cryptococcal granuloma or abscess often simulates brain abscess, glioma and metastatic brain tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Rat pituitary adenoma and hyperplasia induced by caffeine administration.

The effect of caffeine by oral administration on female Wistar rats was studied for 12 months. High concentrations (2000 micrograms/mL) of caffeine caused a decrease in body weight and an increase in the weight of the pituitary gland in these rats. Increased pituitary weight was caused by the growth of a pituitary adenoma or hyperplasia. Pituitary adenomas and instances of hyperplasia were found in 27 of the 40 rats in the caffeine group, compared to 9 of the 30 rats in the control group. The histologic classification used was microadenoma, papillary (or sinusoidal) macroadenoma, and diffuse macroadenomas. These adenomas appeared to be endocrinologically nonfunctioning.

Adenoma↗

Choriocarcinoma arising from the pituitary fossa with extracranial metastasis: a review of the literature.

Since Askanazy's first report on a case of primary intracranial choriocarcinoma in 1906, more than 60 cases have been reported so far. We add to that a case of intrasellar choriocarcinoma with suprasellar extension: A 12-year-old girl showed cranial nerve palsies, hypopituitarism, and abnormally high titers of human chorionic gonadotropin (HCG) in blood and in cerebrospinal fluid (CSF). She died 3 months after surgery. At autopsy, an intra- and suprasellar choriocarcinoma, which penetrated through the clivus into the cerebellopontine angle and metastasized remotely to the lungs, was confirmed. This rare case is presented with a thorough review of the literature.

Adolescent↗

The Nd:YAG laser in neurological surgery.

The Nd:YAG laser has been applied in microneuro-surgery and has been found to be quite effective in removing had and hemorrhagic tumors such as meningiomas, tumors of the deep skull base, or tumors deep in the ventricle. Another indication for the use of the Nd:YAG laser is to open the thick sellar floor in transsphenoidal operations.

Adenoma↗

[Investigations on physiological values of blood in industrial workers. Report 2. Serum lipid values].

In order to establish the physiological values of serum lipids in healthy workers, 1,728 workers aged 35 years and over (1,035 males and 693 females) were examined after the over-night fast. Serum total cholesterol and serum triglycerides were measured by enzyme method. High density lipoprotein-cholesterols were measured by precipitation method (heparin-Mn2+) and beta-lipoprotein also by precipitation method (heparin-Ca2+). Ratios of total cholesterols to HDL-cholesterols and beta-lipoproteins to HDL-cholesterols were calculated. The results obtained are as follows: (1) Frequency distributions of 4 sorts of lipid values and 2 indices fitted approximately to the log-normal distribution. (2) High positive correlation coefficients were found between three lipid measurements, i.e. total cholesterol, triglyceride and beta-lipoprotein, in both men and women. High positive correlation coefficient was found between two ratios, total cholesterol/HDL-cholesterol and beta-lipoprotein/HDL-cholesterol. (3) Geometric means and, 5-95th percentile values in bracket were 184.5 (135-253) mg/dl for total cholesterol in men, 185.4 (139-247) mg/dl for total cholesterol in women, 84.9 (38-188) mg/dl for triglyceride in men, 71.3 (40-126) mg/dl for triglyceride in women, 47.9 (28-81) mg/dl for HDL-cholesterol in men, 51.5 (33-80) mg/dl for HDL-cholesterol in women, 348.3 (211-577) mg/dl for beta-lipoprotein in men, 306.9 (193-489) mg/dl for beta-lipoprotein in women, 3.9 (2.3-6.6) for total cholesterol/HDL-cholesterol in men, 3.6 (2.3-5.7) for total cholesterol/HDL-cholesterol in women, 7.3 (3.6-14.6) for beta-lipoprotein/HDL cholesterol in men, and 6.0 (3.1-11.7) for beta-lipoprotein/HDL-cholesterol in women. (4) Group average values of total cholesterol, triglyceride, beta-lipoprotein, total cholesterol/HDL-cholesterol and beta-lipoprotein/HDL-cholesterol tended to increase with age in women. These differences by age were statistically significant. (5) Mean values of HDL-cholesterol were higher in women than in men in all age groups.

Adult↗

[Investigations on physiological values of blood in industrial workers. Report 3. Serum colloid reaction and enzyme activity values].

The purpose of this study is establish the physiological values of serum colloid reaction and serum enzyme activities representing the liver function. 1,732 industrial workers (1,035 males aged 35-65 yr, and 697 females aged 35-60 yr) were examined by the serum zinc sulfate turbidity test (ZTT) and serum thymol turbidity test (TTT) according to the standard method of "The Japanese society of gastroenterology," serum alkaline phosphatase (ALP) by Kind-King method, serum gamma-glutamyl transpeptidase (gamma-GTP) by the modified Orlowski method, and serum glutamic oxaloacetic transaminase (GOT) and serum glutamic pyruvic transaminase (GPT) by UV method. Then frequency distributions, geometric means, several percentile values of these six laboratory data and correlations among the values were determined. The results are as follows: 1) Frequency distributions of serum ZTT, TTT, ALP, gamma-GTP, GOT, and GPT almost fitted to the log-normal distribution. 2) Geometric means and 0-95th percentile or 5-95th percentile values in bracket were 6.6 (3.7-11.7) Kunkel unit for ZTT in male, 8.2 (5.1-13.0) Kunkel unit for ZTT in female, 0.6 (0-2.8) Kunkel unit for TTT in male, 0.8 (0-2.8) Kunkel unit for TTT in female, 6.6 (4.1-10.4) King-Armstrong unit for ALP in male, 5.5 (3.2-8.9 for 49 year or less, 4.6-10.3 for 50 yr or more) King-Armstrong unit for ALP in female, 15.8 (0-45) mU/ml for gamma-GTP in male, 8.4 (0-17 for 44 yr or less, and 0-20 for 45 yr or more) mU/ml for gamma-GTP in female, 21.4 (0-39) Karmen unit for GOT in male, 20.8 (0-35) Karmen unit for GOT in female, 13.9 (0-29) Karmen unit for GPT in male, and 12.7 (0-32) Karmen unit for GPT in female. 3) Serum ZTT and TTT levels were higher in female than in male. Both ALP and gamma-GTP levels were higher in male than in female, and have become high according to aging in female. Serum level of GPT was higher in male than in female. 4) There were significant positive correlations between serum ZTT and serum TTT levels, and also between serum GOT and serum GPT levels.

Adult↗

Long-term prognosis of behavior therapy in practice.

A prognosis study was carried out on 30 cases of patients treated with behavior therapy. The treatments, which took more than three years before the study, averaged four years and eight months. The results are as follows: (1) The improvement achieved by therapy was maintained or further improved in 29 cases during the post-therapeutic period of more than three years. (2) The prognosis largely depended on the grade of improvement at the end of therapy. A complete disappearance of symptoms at the end of therapy did not necessarily mean that it was a fair prognosis. (3) There was no relation between the prognosis and the length of history of illness or the situation of therapy terminated. (4) The impression is that long-term prognoses are different depending on the main symptoms.

Adolescent↗