PubMed Health⌕ Search

Biomedical subjects

T Yue

Publications and source records attributed to T Yue.

8 recordsLinked to original sources
PubMed2001

Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats.

This study investigated whether idoxifene, a selective estrogen receptor modulator (SERM), exerted protective effects against ischemia-reperfusion-induced shock. Ovariectomized rats were treated with vehicle, idoxifene, or 17beta-estradiol for 4 days. Rats were subjected to splanchnic artery occlusion (SAO) followed by reperfusion (SOA/R). In vehicle-treated rats, SAO/R resulted in hypotension, hemoconcentration, increased plasma tumor necrosis factor (TNF)-alpha levels, intestinal neutrophil accumulation, and endothelial dysfunction. 17beta-Estradiol treatment increased plasma estradiol concentration and reduced SAO/R-induced tissue injury. Idoxifene treatment had no effect on plasma estradiol concentration but reduced SAO/R-induced hemoconcentration (+8.8 +/- 1.3 vs. +14 +/- 1.3% in the vehicle group, P < 0.01), TNF-alpha production (98 +/- 3.2 vs. 214 +/- 13 pg/ml, P < 0.01), and neutrophil accumulation (0.025 +/- 0.005 vs. 0.047 +/- 0.005 U/g protein, P < 0.01). It also improved endothelial function, prolonged survival time (172 +/- 3.5 vs. 147 +/- 8 min, P < 0.01), and increased survival rate (69 vs. 23%, P < 0.01). Moreover, treatment with 17beta-estradiol or idoxifene in vivo reduced TNF-alpha-induced endothelial dysfunction in vitro. Taken together, these results demonstrated that idoxifene exerted estrogen-like, endothelial-protective, and antishock effects in ovariectomized rats, suggesting that SERMs have therapeutic potential in tissue injury resulting from ischemia-reperfusion.

Animals↗
PubMed2001

Pathological, ultrastructural and immunohistochemical observations of adenoma of retinal pigment epithelium.

PURPOSE: To Study the clinical, pathological, ultrastructural and immunohistchemical characters of adenoma of the retinal pigment epithelium in order to offer evidence to diagnose this tumor. METHODS: Routine paraffin slices HE stain, histochemistry PAS and VG stain, transmission electron microscopy, and immunohistochemistry for S-100 and vimentin with LSAB method were used. RESULTS: The tumor cells were oval and cuboidal in shape. Part of the tumor had a tubular arrangement. Around the sheets of tumors cells there was a large amount of uniform red stick-like substances. The above matter represented positive in PAS stain. Most of the above matter was yellow, while less of the matter showed red in VG stain. Transmission electron microscopy showed that there were tight junctions between tumor cells. Immunohistochemistry showed positive for S-100, negative for vimentin. CONCLUSIONS: The ultrastructural and immunohistochemical characters of the adenoma of retinal pigment epithelium are consistent with the retinal pigment epithelium.

Adenoma↗
PubMed1994

Arteriovenous shunt as a method of restoring venous drainage in rabbit ear replantation.

An arteriovenous (AV) shunt as a method of restoring venous drainage during replantation was examined by use of the rabbit ear model. The results were compared to ears replanted using one vein (1:1) or two veins (2:1) for venous drainage. The success rate for AV shunt replantations was found similar to that of replantations with a 1:1 ratio, but lower than that of ears with a 2:1 ratio. Postoperatively, ears replanted using an AV shunt or a 1:1 ratio revealed more swelling and lower tissue oxygenation than ears with a 2:1 ratio. After 10-14 days, all ears that survived were similar in appearance, regardless of method of replantation. Microscopic venules crossing the replanted interface appeared at seven days following surgery in all groups. The authors conclude that the AV shunt method offers an alternative to venous anastomosis when vein-to-vein reconstruction cannot be established.

Anastomosis, Surgical↗
PubMed1991

Subungual exostosis.

From 1980 through 1990, twenty-two patients with subungual exostosis were treated in PUMC Hospital and the Sixth Hospital of Beijing. The incidence of subungual exostosis was 4.6% among all bone tumors. Post-adolescents and young adults were most commonly affected, and the female to male ratio was 1.75 to 1. The great toe was the most often involved site. Radiological findings were found to be diagnostic, and local tumor excision is the treatment of choice.

Adolescent↗
PubMed1990

Diagnosis and treatment of idiopathic necrosis of the femoral head.

Fifteen cases, 27 hips, of idiopathic necrosis of the femoral head (INFH) were included in our series. The roles of radiography, isotopic bone scanning, intraosseous pressure measurement and intraosseous venography in the diagnosis of INFH were evaluated. Radiological examination could not reveal early cases, while isotopic bone scanning was more sensitive. There was an increase of intraosseous pressure in most of the diseased hips, and intraosseous venography showed abnormalities in all examined hips. The latter two tests could therefore detect early INFH. Core decompression was performed in 23 hips, 21 of which were followed for 7 to 27 months. Functional evaluation was good or excellent in 18 hips. Radiological re-examination remained unchanged in 19 hips. Postoperative intraosseous pressure measurement and intraosseous venography revealed a decrease of intraosseous pressure and improvement of venous drainage. Core decompression is therefore an ideal method of treatment for early INFH.

Adult↗
PubMed1989

[Intraosseous pressure measurement and bone marrow venography in idiopathic necrosis of femoral head].

Intraosseous pressure measurement and bone marrow venography were performed in 14 patients (25 hips) with idiopathic necrosis of femoral head. Increase of intraosseous baseline pressure was found in 95% of hips, positive stress test found in 91% of hips and venous stasis present in all cases. Core decompression could reduce intraosseous pressure and improve venous drainage. It was suggested that intraosseous hyperpressure and venous stasis play an important role in the pathogenesis of idiopathic necrosis of femoral head. The authors suggest that intraosseous pressure measurement and bone marrow venography are sensitive in revealing early stage changes of idiopathic femoral head necrosis.

Adult↗
PubMedDate not supplied

BMP-2 gene expression and effects on human vascular smooth muscle cells.

Bone morphogenetic proteins (BMPs) and their serine/threonine kinase receptors have been identified in atherosclerotic arteries and vascular smooth muscle cells, respectively. Thus, BMPs (the largest subfamily of the TGF-beta superfamily) have been implicated in the pathogenesis of atherosclerosis. However, the origins of BMP biosynthesis and the functional roles of BMP in blood vessels are unclear. The present study explored BMP-2 gene expression in various human blood vessels and vascular cell types. Functional in vitro studies were also performed to determine the effects of recombinant human BMP-2 on migration (transwell assay) and proliferation ([3H]-thymidine incorporation) of human aortic vascular smooth muscle cells (HASMC). RT-PCR experiments revealed BMP-2 gene expression in normal and atherosclerotic human arteries as well as cultured human aortic and coronary vascular smooth muscle cells, human umbilical vein endothelial cells (HUVECs) and human macrophages. In cellular migration studies, incubation with BMP-2 produced efficacious (</=610-fold), concentration- and time-dependent chemotaxis of HASMCs (EC50 = 0.8 microM) with little or no effect on HUVEC chemotaxis. The increased HASMC motility induced by BMP-2 was inhibited by coincubation with an anti-BMP-2 mAb. In addition, subthreshold concentrations of BMP-2 produced a dramatic synergistic effect upon platelet-derived growth factor (PDGF)-induced chemotaxis. In contrast to PDGF, BMP-2 had no significant effet on [3H]-thymidine incorporation in HASMC at chemotaxic concentrations (</=6.0 microM) nor did it synergize with the mitogenic effects of PDGF. In conclusion, the expression of BMP-2 by numerous cell types in the blood vessel wall may play a chemotactic or cochemotactic role in the smooth muscle cell response to vascular injury.

Aorta↗